Aberrant tumor vasculature. Facts and pitfalls [PDF]
Frontiers in PharmacologyEndothelial cells form a single cell layer lining the inner walls of blood vessels and play critical roles in organ homeostasis and disease progression.
Domenico Ribatti
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Immunotherapies targeting tumor vasculature: challenges and opportunities [PDF]
Frontiers in Immunology, 2023 Angiogenesis is a hallmark of cancer biology, and neoadjuvant therapies targeting either tumor vasculature or VEGF signaling have been developed to treat solid malignant tumors.
Hassan Dianat-Moghadam +7 more
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Tumor Vasculature as an Emerging Pharmacological Target to Promote Anti-Tumor Immunity. [PDF]
Int J Mol Sci, 2023 Tumor vasculature abnormality creates a microenvironment that is not suitable for anti-tumor immune response and thereby induces resistance to immunotherapy. Remodeling of dysfunctional tumor blood vessels by anti-angiogenic approaches, known as vascular
Tzeng HT, Huang YJ.
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GPU-accelerated volumetric-mosaic optical-resolution photoacoustic microscopy and quantifying tumor vasculature growth [PDF]
PhotoacousticsTumor growth is closely linked to vascular remodeling, yet comprehensive volumetric imaging of tumor vasculature using photoacoustic microscopy (PAM) remains challenging due to limitations in the field of view, depth penetration, and processing speed ...
Thanh Dat Le +5 more
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Human Patient-Derived Brain Tumor Models to Recapitulate Ependymoma Tumor Vasculature [PDF]
Bioengineering, 2023 Despite in vivo malignancy, ependymoma lacks cell culture models, thus limiting therapy development. Here, we used a tunable three-dimensional (3D) culture system to approximate the ependymoma microenvironment for recapitulating a patient’s tumor in ...
Min D. Tang-Schomer +3 more
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JP1 normalizes tumor vasculature to suppress metastasis and facilitate drug delivery by inhibiting IL-8 [PDF]
JCI Insight, 2023 Tumor vascular normalization prevents tumor cells from breaking through the basement membrane and entering the vasculature, thereby inhibiting metastasis initiation.
Jiahua Cui +9 more
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A dhesion analysis via a tumor vasculature-like microfluidic device identifies CD8+ T cells with enhanced tumor homing to improve cell therapy [PDF]
Cell Reports, 2023 Summary: CD8+ T cell recruitment to the tumor microenvironment is critical for the success of adoptive cell therapy (ACT). Unfortunately, only a small fraction of transferred cells home to solid tumors.
Camila P. Camargo +8 more
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Tumor vasculature: a sally port for inhibiting cancer cell spreading
Cancer Communications, 2018 The close relationship between metastasis and establishment of tumor vasculature has inspired enormous research interests aiming to suppress metastasis via inhibiting the development of tumor vasculature.
Chao-Nan Qian, Francesco Pezzella
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Cancer Management and Research, 2019 Kentaro Inamura,1,2 Gulanbar Amori,1,2 Takeshi Yuasa,3 Shinya Yamamoto,3 Junji Yonese,3 Yuichi Ishikawa1,21Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan; 2Department of Pathology, The Cancer ...
Inamura K +5 more
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Nucleic Acid Sensing in the Tumor Vasculature. [PDF]
Cancers (Basel), 2021 Endothelial cells form a powerful interface between tissues and immune cells. In fact, one of the underappreciated roles of endothelial cells is to orchestrate immune attention to specific sites. Tumor endothelial cells have a unique ability to dampen the immune responses and thereby maintain an immunosuppressive microenvironment.
Baris AM, Fraile-Bethencourt E, Anand S.
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