Results 121 to 130 of about 1,359,527 (294)

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Tumor vasculature targeted therapies

, 1998
Based on their location and central role in solid tumor growth, tumor vascular endothelial cells may present an attractive target for the delivery of therapeutic drugs or cells.
Meijer, D.K F, de Leij, Lou, Grietje Molema, Molema, G; id_orcid, Lou F.M.H de Leij, Dirk K.F Meijer, Molema, Ingrid   +6 more
core   +1 more source

EndoTac: An Endoscopic Camera‐Based Tactile Sensor with High Sensitivity for Minimally Invasive Surgery

Advanced Science, EarlyView.
EndoTac presents a trocar‐compatible endoscopic vision‐based tactile sensor that uses a convex mirror to enlarge side‐facing tactile coverage during minimally invasive vessel palpation. Distorted tactile images are unwarped and processed by a learning model to estimate vascular deformation, enabling sensitive, spatially distributed tactile perception ...
Yupeng Wang, Nicolas Raison, Xuyang Zhang, Aijia Yang, Lukas Lindenroth, Shan Luo   +5 more
wiley   +1 more source

T time for tumor vasculature [PDF]

Science-Business eXchange, 2010
Scientists from NCI have shown that engineered VEGFR-2–targeting T cells can stop tumor growth. Although these findings are already being tested in a Phase I/II trial to treat metastatic cancer, the complexity of the technique could make its commercialization challenging.
openaire   +1 more source

Isolation of targeting nanobodies against co-opted tumor vasculature. [PDF]

, 2010
Contains fulltext : 87890.pdf (Publisher’s version ) (Closed access)Tumor vasculature is in general highly heterogeneous. This characteristic is most prominent in high-grade gliomas, which present with areas of angiogenic growth, next ...
Franssen, M., Donk, T. van der, Zuidscherwoude, M.C.M., Leenders, W.P.J., Roodink, I., Verrijp, K., Raats, J.   +6 more
core   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Support of Tumor Endothelial Cells by Chemokine Receptors

Frontiers in Immunology, 2019
Tumor-associated vascular endothelium comprises a specialized and diverse group of endothelial cells that, although not cancer themselves, are integral to cancer progression. Targeting the tumor vasculature can have significant efficacy in reducing tumor
Nicole Salazar, Brian A. Zabel
doaj   +1 more source

Biologic Effects of Dopamine on Tumor Vasculature in Ovarian Carcinoma [PDF]

, 2013
Chronic sympathetic nervous system activation results in increased angiogenesis and tumor growth in orthotopic mouse models of ovarian carcinoma. However, the mechanistic effects of such activation on the tumor vasculature are not well understood ...
Siddik, Zahid H, Chunhua Lu, Ju-Won Roh, Jennings, Nicholas B, Susan K Lutgendorf, Han, Hee Dong, He, Guangan, Koji Matsuo, Robert R Langley, Yu Kang, Steve W Cole, Matsuo, Koji, Justin Bottsford-Miller, Shahzad, Mian M K, Lee, Sun Joo, Guangan He, Langley, Robert R, Julie K Allen, Masato Nishimura, Mian M K Shahzad, Allen, Julie K, Sood, Anil K, Myrthala Moreno-Smith, Roh, Ju-Won, Cole, Steve W, Lutgendorf, Susan K, Moreno-Smith, Myrthala, Nagaraja, Archana S, Sun Joo Lee, Lu, Chunhua, Anil K Sood, Bottsford-Miller, Justin, Armaiz, Guillermo N, Rajesha Rupaimoole, Kang, Yu, Nicholas B Jennings, Guillermo N Armaiz, Nishimura, Masato, Rupaimoole, Rajesha, Hee Dong Han, Zahid H Siddik, Archana S Nagaraja   +41 more
core   +1 more source

Engineering Ultrastable Intrinsic Radicals: Graphene Quantum Dots With NIR‐II Emission for Dynamic Deep‐Tissue Bioimaging

Advanced Science, EarlyView.
Stable radicals are attractive for photonic and quantum information technologies but are often limited by instability. We stabilize intrinsic radicals in graphene quantum dots via 2D polymerization of perylene derivatives, where bilayer defect confinement suppresses quenching (100–500 K).
Qin Xu, Yijie Hou, Bingzhe Wang, Tesen Zhang, Yupeng Liu, Shuaiqi Li, Maohua Chen, Guichuan Xing, Dongbo Guo, Songnan Qu   +9 more
wiley   +1 more source

A Proposed Paradigm Shift in Initializing Cancer Predictive Models with DCE-MRI Based PK Parameters: A Feasibility Study

Cancer Informatics, 2015
Glioblastoma multiforme is the most aggressive type of glioma and the most common malignant primary intra-axial brain tumor. In an effort to predict the evolution of the disease and optimize therapeutical decisions, several models have been proposed for ...
Alexandros Roniotis, Mariam-Eleni Oraiopoulou, Eleftheria Tzamali, Eleftherios Kontopodis, Sofie Van Cauter, Vangelis Sakkalis, Kostas Marias   +6 more
doaj   +1 more source