Results 141 to 150 of about 1,359,527 (294)

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Vascular Endothelial Growth Factor/Angiopoietin‐2 Bispecific Antibody‐Induced Vascular Normalization: From Basic Mechanisms to Therapeutic Applications in Breast Cancer

Immunity, Inflammation and Disease
Abnormal tumor vasculature is a hallmark of breast cancer, characterized by tortuous, hyperpermeable, and poorly perfused vessels that contribute to hypoxia, therapeutic resistance, and immune exclusion.
Meng Li, Fengjuan Han, Shuang Ling, Xiaoyue Su, Yuxin Zhao, Shaowa Lv, Xiwu Zhang   +6 more
doaj   +1 more source

Abstract 5196: Recoupling nitric oxide synthetase to normalize tumor vasculature and enhance tumor radiosensitivity and anti-tumor drug uptake

, 2017
The aberrant nature of tumor vasculature results in uneven, heterogeneous blood flow and leaky, hemorrhagic blood vessels. Due to the unusual nature of tumor vessels, areas of hypoxia develop that contribute to radioresistance and inefficiency of ...
Li Wang, Jamal Zweit, Christopher S. Rabender, Ross B. Mikkelsen, Sundaresan Gobalakrishnan   +4 more
core   +1 more source

Inorganic Nanomaterials can Promote or Inhibit Tumor Metastasis Depending on Tumor Microenvironment Composition

Advanced Science, EarlyView.
As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens, Xiaoqi Zheng, Xueqi Fan, Mukaddes Izci, Christy Maksoudian, Irati Perez Gilabert, Tianjiao Chu, Filipa Goncalves, Jonas Dehairs, Johan Swinnen, Bella B. Manshian, Stefaan J. Soenen   +11 more
wiley   +1 more source

99mTc-labeled tricarbonyl His-CNA35 as an imaging agent for the detection of tumor vasculature

, 2012
Given the importance of angiogenesis for a tumor's survival and growth, several therapeutic strategies rely on the selective inhibition of angiogenesis and the destruction of existing tumor vasculature.
Dierckx, Rudi, D'Asseler, YvesGE32UZGent8010011514280000-0002-8807-2257F5413AC2-F0ED-11E1-A9DE-61C894A0A6B4, Van Damme, NancyGE108010010669568701105717772DB88A54-F0EE-11E1-A9DE-61C894A0A6B4, Mertens, KoenUGent002002007753802000416530976016785516FAE7AA88-F0ED-11E1-A9DE-61C894A0A6B4, Van Steenkiste, MagaliFW02801001876302001999212133F731416A-F0ED-11E1-A9DE-61C894A0A6B4, Van Steenkiste, Magali, Reutelingsperger, Chris, D'Asseler, Yves, Dierckx, RudiUGent801001088275975606544224F505EC92-F0ED-11E1-A9DE-61C894A0A6B4, Vermeire, Simon, Peremans, KathelijneUGent0019611944968010006692569718000003040000-0002-1118-9684F44FD7FE-F0ED-11E1-A9DE-61C894A0A6B4, Peremans, Kathelijne, Mees, GillesGE1600200232684380200093456914F2D538-F0EE-11E1-A9DE-61C894A0A6B4, Mees, Gilles, Mertens, Koen, Van De Wiele, ChristopheGE320001405490578010017617200000-0002-4370-5954F6CD349A-F0ED-11E1-A9DE-61C894A0A6B4, Van Damme, Nancy, Vermeire, SimonUGent802000116537001999045314F8A50ACC-F0ED-11E1-A9DE-61C894A0A6B4, Van De Wiele, Christophe   +18 more
core   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

Advanced Science, EarlyView.
Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok, Laura Činč Ćurić, Jernej Vajda, Silvia Schauer, Martin Wagner, Rudolf Stauber, Carolin Lackner, Karl Kashofer, Markus Plass, Giovanny Rodriguez Blanco, Ian R. Wanless, Uroš Maver, Katrin Panzitt, Boštjan Vihar   +13 more
wiley   +1 more source

OncoLog: A Report to Physicians

, 1983
Quarterly newsletter from the University of Texas System Cancer Center, M.D.
Eisen, Leslie L., M.D. Anderson Hospital and Tumor Institute   +1 more
core