Results 11 to 20 of about 3,547,100 (335)
Gold nanoparticle-enhanced radiotherapy: Dependence of the macroscopic dose enhancement on the microscopic localization of the nanoparticles within the tumor vasculature. [PDF]
PLoS ONEIn gold nanoparticle-enhanced radiotherapy, intravenously administered nanoparticles tend to accumulate in the tumor tissue by means of the so-called permeability and retention effect and upon irradiation with x-rays, the nanoparticles release a ...
C A Díaz-Galindo, H M Garnica-Garza
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Non-immune functions of B7-H3: bridging tumor cells and the tumor vasculature [PDF]
Frontiers in OncologyB7-H3 (CD276), an immune checkpoint molecule, is overexpressed in various types of cancer and their tumor vasculature, demonstrating significant associations with adverse clinical outcomes.
Shuo Wu +4 more
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Science Translational Medicine, 2021 Disruption of the molecular interaction between CD93 and IGFBP7 improves tumor vascular functions and thereby facilitates therapeutic interventions. Fixing faulty tumor vessels Solid tumors have structurally abnormal blood vessels that lead to decreased ...
Yi Sun +22 more
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Cancer Cell International, 2023 The tumor vasculature was different from the normal vasculature in both function and morphology, which caused hypoxia in the tumor microenvironment (TME). Previous anti-angiogenesis therapy had led to a modest improvement in cancer immunotherapy. However,
Yang Li +12 more
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Directing CAR T cells towards the tumor vasculature for the treatment of solid tumors.
Biochimica et biophysica acta. Reviews on cancer, 2022 For successful application of chimeric antigen receptor (CAR) T cell therapy in solid tumors, major hurdles have to be overcome. CAR T cells have to cross the vascular barrier, which is hampered by the anergic state of the tumor vasculature ...
P. Akbari +6 more
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Normalizing Tumor Vasculature to Reduce Hypoxia, Enhance Perfusion, and Optimize Therapy Uptake
Cancers, 2021 Simple Summary In order for solid tumors to grow, they need to develop new blood vessels in order to support their increasing metabolic requirements. To facilitate the novel vessel formation, the tumor initiates an aggressive pro-angiogenic program. As a
K. Matuszewska +4 more
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Heterogeneity of tumor vasculature and antiangiogenic intervention: insights from MR angiography and DCE-MRI. [PDF]
PLoS ONE, 2014 Solid tumor vasculature is highly heterogeneous, which presents challenges to antiangiogenic intervention as well as the evaluation of its therapeutic efficacy.
Wenlian Zhu +2 more
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Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature
Frontiers in Oncology, 2021 Solid tumors are dependent on vascularization for their growth. The hypoxic, stiff, and pro-angiogenic tumor microenvironment induces angiogenesis, giving rise to an immature, proliferative, and permeable vasculature.
Aukie Hooglugt +3 more
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Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors
Nature Communications, 2023 Targeting DNA methyltransferase 1 (DNMT1) has immunomodulatory and anti-neoplastic activity, especially when paired with cancer immunotherapies. Here we explore the immunoregulatory functions of DNMT1 in the tumor vasculature of female mice.
Dae Joong Kim +11 more
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