Results 21 to 30 of about 3,547,100 (335)
Visualizing vasculature and its response to therapy in the tumor microenvironment
Theranostics, 2023 Tumor vasculature plays a critical role in the progression and metastasis of tumors, antitumor immunity, drug delivery, and resistance to therapies. The morphological and functional changes of tumor vasculature in response to therapy take place in a ...
Qiaoya Lin, Peter L. Choyke, Noriko Sato
semanticscholar +1 more source
Platelets: Guardians of Tumor Vasculature [PDF]
Cancer Research, 2009 Abstract Solid tumors generate a prothrombotic environment capable of platelet activation. Recent findings indicate that the activated platelets are crucial regulators of tumor vascular homeostasis in that they prevent tumor hemorrhage. Surprisingly, this effect is independent of platelets' capacity to form thrombi and instead relies on ...
Benoit, Ho-Tin-Noé +2 more
openaire +2 more sources
Heterogeneity of the Tumor Vasculature [PDF]
Seminars in Thrombosis and Hemostasis, 2010 The blood vessels supplying tumors are strikingly heterogeneous and differ from their normal counterparts with respect to organization, structure, and function. Six distinctly different tumor vessel types have been identified, and much has been learned about the steps and mechanisms by which they form.
Janice A, Nagy +4 more
openaire +2 more sources
Engineering tumoral vascular leakiness with gold nanoparticles
Nature Communications, 2023 Delivering cancer therapeutics to tumors necessitates their escape from the surrounding blood vessels. Tumor vasculatures are not always sufficiently leaky. Herein, we engineer therapeutically competent leakage of therapeutics from tumor vasculature with
Magdiel Inggrid Setyawati +8 more
doaj +1 more source
Cancer therapeutic potential of combinatorial immuno- and vaso-modulatory interventions [PDF]
, 2015 Currently, most of the basic mechanisms governing tumor-immune system interactions, in combination with modulations of tumor-associated vasculature, are far from being completely understood.
Alfonso, J. C. L. +5 more
core +3 more sources
Quantifying the effects of antiangiogenic and chemotherapy drug combinations on drug delivery and treatment efficacy. [PDF]
PLoS Computational Biology, 2017 Tumor-induced angiogenesis leads to the development of leaky tumor vessels devoid of structural and morphological integrity. Due to angiogenesis, elevated interstitial fluid pressure (IFP) and low blood perfusion emerge as common properties of the tumor ...
Sirin Yonucu +4 more
doaj +1 more source
Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy
Molecular Imaging, 2020 Asn-Gly-Arg (NGR) motifs have vasculature-homing properties via interactions with the aminopeptidase N (CD13) expressed on tumor neovasculature. Numerous NGR peptides with different molecular scaffolds have been exploited for targeted delivery of ...
Liqin Zhu MD +4 more
doaj +1 more source
Tumor spheroid-based and microtumor-based vascularized models for replicating the vascularized tumor microenvironment [PDF]
Organoid, 2023 Background Tumor vasculature is a crucial pathway for supplying nutrients and oxygen to tumors during their progression, as well as facilitating the delivery of anticancer drugs or immunotherapeutic agents.
Jiyoung Song +4 more
doaj +1 more source
Defining the role of the tumor vasculature in antitumor immunity and immunotherapy
Cell Death and Disease, 2018 It is now well established that cancer cells co-exist within a complex environment with stromal cells and depend for their growth and dissemination on tight and plastic interactions with components of the tumor microenvironment (TME). Cancer cells incite
Marco B. E. Schaaf +2 more
semanticscholar +2 more sources
BMC Genomics, 2008 Background Targeting tumor angiogenesis and vasculature is a promising strategy for the inhibition of tumor growth and dissemination. Evidence suggests that tumor vasculature expresses unique markers that distinguish it from normal vasculature.
Giavazzi Raffaella +5 more
doaj +1 more source