Results 31 to 40 of about 3,547,100 (335)

Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity

Cancer Cell, 2022
Summary Glioblastoma (GBM) is poorly responsive to therapy and invariably lethal. One conceivable strategy to circumvent this intractability is to co-target distinctive mechanistic components of the disease, aiming to concomitantly disrupt multiple ...
Agnieszka Chryplewicz, Julie Scotton, M. Tichet, A. Zomer, Ksenya Shchors, J. Joyce, K. Homicsko, D. Hanahan   +7 more
semanticscholar   +1 more source

Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment

Biomarker Research, 2021
Tumor angiogenesis induces local hypoxia and recruits immunosuppressive cells, whereas hypoxia subsequently promotes tumor angiogenesis. Immunotherapy efficacy depends on the accumulation and activity of tumor-infiltrating immune cells (TIICs ...
Wuzhen Chen, Lesang Shen, Jingxin Jiang, Leyi Zhang, Zhigang Zhang, Jun Pan, Chao Ni, Zhigang Chen   +7 more
doaj   +1 more source

Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy [PDF]

, 2011
This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network ...
Cai, Y, Cao, J, Long, Q, Lv, J, Xu, S, Yao, W, Zhou, Y   +6 more
core   +2 more sources

Untangling Tumor Vasculature

The FASEB Journal, 2013
Tumor vasculature is highly dynamic, dense, and non‐homogeneous. These features make it difficult to identify key determinants of tumor angiogenesis and remodeling at the single vessel level. To overcome this problem, we isolated growing tumors from the host tissue, by placing a perforated PDMS disk between the tumor and the dorsal skin in transparent ...
Gabriel Gruionu, Despina Bazou, Johnatan Song   +2 more
openaire   +1 more source

Zebrafish functional xenograft vasculature platform identifies PF-502 as a durable vasculature normalization drug

iScience, 2023
Summary: Tumor vasculature often exhibits disorder and inefficiency. Vascular normalization offers potential for alleviating hypoxia and optimizing drug delivery in tumors.
Jian Zhong, Chaoxin Xiao, Qin Chen, Xiangyu Pan, Tongtong Xu, Yiyun Wang, Wanting Hou, Lu Liu, Fujun Cao, Yulin Wang, Xiaoying Li, Lin Zhou, Hanshuo Yang, Yu Yang, Chengjian Zhao   +14 more
doaj   +1 more source

FUS-CHOP promotes invasion in myxoid liposarcoma through a SRC/FAK/RHO/ROCK-dependent pathway [PDF]

, 2017
Deregulated SRC/FAK signaling leads to enhanced migration and invasion in many types of tumors. In myxoid and round cell liposarcoma (MRCLS), an adipocytic tumor characterized by the expression of the fusion oncogene FUS-CHOP, SRC have been found as one ...
González, M. Victoria, Hermida Prado, Francisco, Singh Singh, Ranjit, Tornin Cavielles, Juan   +3 more
core   +2 more sources

Multiparametric MRI enables for differentiation of different degrees of malignancy in two murine models of breast cancer

Frontiers in Oncology, 2022
ObjectiveThe objective of this study was to non-invasively differentiate the degree of malignancy in two murine breast cancer models based on identification of distinct tissue characteristics in a metastatic and non-metastatic tumor model using a ...
Mirjam Gerwing, Mirjam Gerwing, Emily Hoffmann, Emily Hoffmann, Katharina Kronenberg, Uwe Hansen, Max Masthoff, Max Masthoff, Anne Helfen, Anne Helfen, Christiane Geyer, Christiane Geyer, Lydia Wachsmuth, Lydia Wachsmuth, Carsten Höltke, Carsten Höltke, Bastian Maus, Bastian Maus, Verena Hoerr, Verena Hoerr, Verena Hoerr, Tobias Krähling, Tobias Krähling, Lena Hiddeßen, Walter Heindel, Walter Heindel, Uwe Karst, Melanie A. Kimm, Regina Schinner, Michel Eisenblätter, Michel Eisenblätter, Michel Eisenblätter, Cornelius Faber, Cornelius Faber, Moritz Wildgruber, Moritz Wildgruber, Moritz Wildgruber   +36 more
doaj   +1 more source

PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor [PDF]

, 2019
Ovarian cancer is the fifth leading cause of cancer-related deaths in women. In the past 20 years, the canonical types of drugs used to treat ovarian cancer have not been replaced and the survival rates have not changed.
Abramovich, Dalhia Nurit, Bocchicchio, Sebastian, Irusta, Griselda, May, Maria, Parborell, Maria Fernanda Agustina, Pazos Maidana, María Camila, Sequeira, Gonzalo Ricardo, Tesone, Marta   +7 more
core   +1 more source

Subsequent Ultrasound Vascular Targeting Therapy of Hepatocellular Carcinoma Improves the Treatment Efficacy

Biology, 2021
The response of hepatocellular carcinoma (HCC) to anti-vascular ultrasound therapy (AVUS) can be affected by the inherent differences in tumor vascular structure, and the functionality of tumor vessels at the time of treatment. In this study, we evaluate
Laith R. Sultan, Mrigendra B. Karmacharya, Stephen J. Hunt, Andrew K.W. Wood, Chandra M. Sehgal   +4 more
doaj   +1 more source

Computer simulation of glioma growth and morphology [PDF]

, 2007
Despite major advances in the study of glioma, the quantitative links between intra-tumor molecular/cellular properties, clinically observable properties such as morphology, and critical tumor behaviors such as growth and invasiveness remain unclear ...
Adam, Ambrosi, Ambrosi, Anderson, Anderson, Anderson, Anderson, Araujo, Augustin, Bartels, Bello, Bellomo, Berger, Bernsen, Bernsen, Boegler, Brandt, Bullitt, Byrne, Byrne, Byrne, Byrne, Cai, Carmeliet, Chaplain, Chaplain, Chaplain, Chaplain, Condeelis, Cristini, Cristini, Cursiefen, DeJaeger, Derycke, Eble, Elaine L. Bearer, Ellis, Elvin, Fallenstein, Frieboes, Friedl, Friedl, Friedl, Friedman, Garcke, Gatenby, Giese, Greenspan, Hayot, Helmlinger, Hermann B. Frieboes, Holash, Holash, Huang, Jacqmin, Jain, Jain, John S. Lowengrub, Keller, Khoshyomn, Kim, Kim, Kim, Kopfstein, Kuiper, Kumar, Kunkel, Lah, Lamszus, Lee, Leo, Less, Li, Li, Lockett, Lowengrub, Macklin, Macklin, McDougall, McLean, Naganuma, O'Connor, Ommaya, Padera, Page, Patan, Patan, Paul Macklin, Pennacchietti, Plank, Plank, Preusser, Ridley, Rofstad, Rubenstein, S. Wise, Sahai, Sanga, Seftor, Shweiki, Sierra, Sinek, Skinner, Steeg, Sun, Takano, Toker, Tysnes, Vajkoczy, van Kempen, Vittorio Cristini, Wise, Wolf, Wurzel, X. Zheng, Yamaguchi, Yin, Zheng   +117 more
core   +1 more source