Results 61 to 70 of about 269,778 (316)

Clonal structure of rapid-onset MDV-driven CD4+ lymphomas and responding CD8+ T cells.

PLoS Pathogens, 2011
Lymphoid oncogenesis is a life threatening complication associated with a number of persistent viral infections (e.g. EBV and HTLV-1 in humans). With many of these infections it is difficult to study their natural history and the dynamics of tumor ...
William N Mwangi, Lorraine P Smith, Susan J Baigent, Richard K Beal, Venugopal Nair, Adrian L Smith   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Exposure to Abnormal Self Antigens During Non-Malignant Inflammatory Events Provides Immunological Defense Against Tumors [PDF]

, 2013
Cancer immunosurveillance is the body’s sentinel mechanism of recognizing and eliminating malignancy. Specifically, the immune system can mount a response against cancer through the recognition of tumor associated antigens (TAA). While studying two TAAs,
Iheagwara, Uzoma
core  

Response to combination therapy with interferon alfa-2a and ribavirin in chronic hepatitis C according to a TNF-alpha promoter polymorphism [PDF]

, 2003
Background. Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of chronic active hepatitis C. Polymorphisms in the promoter region of the TNF-alpha gene can alter the TNF-alpha expression and modify the host immune response.
Konig, A., Folwaczny, Christian, Schmidt, F., Simperl, C., Schaefer, M., Torok, P., Glas, J., Schiemann, Uwe, Martin, K.   +8 more
core   +1 more source

Human Viral Oncoproteins and Ubiquitin–Proteasome System

Global Medical Genetics
Some human cancers worldwide may be related to human tumor viruses. Knowing, controlling, and managing the viruses that cause cancers remain a problem.
Zahra Rafiei Atani, Sareh Sadat Hosseini, Hossein Goudarzi, Ebrahim Faghihloo   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modulation of immune responses by human paraininfluenza virus [PDF]

, 2007
Human Parainfluenza virus type 3 (HPIV3) is a key respiratory pathogen responsible for bronchiolitis, pneumonia and croup. The persistent nature of this virus and its ability to reinfect within a short space of time has led to successive failures in the ...
Noone, Cariosa
core  

A paradigm for virus-host coevolution: sequential counter-adaptations between endogenous and exogenous retroviruses [PDF]

, 2007
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections of the host germline transmitted 1vertically from generation to generation. It is hypothesized that some ERVs are used by the host as 1restriction factors to block the infection
Pereira, Filipe, LEYMASTER K, Pereira, P., Golder, Matthew, James C Demartini, Leymaster, Kreg, Mura, M., Mura, Manuela, Golder, M., Biek, R., Pereira Filipe, Golder, Matthew C., Arnaud, Frederick, Bernardo Chessa, Yu Li, CAPORALE M, Zhang, Y-P., Matthew Golder, Thomas E Spencer, Caporale Marco, Palmarini, Massimo, Alberti Alberto, Yu, Li, Arnaud Frederick, Biek Roman, Frederick Arnaud, Alberti, A., Arnaud, F., Spencer Thomas E, Ya-Ping Zhang, SPENCER T. E, Caporale, M., Li Yu, Palmarini, M., Varela, M., Kreg Leymaster, PEREIRA F, DeMartini, J.C., Zhang, Ya-ping, Mariana Varela, Spencer, T.E., ZHANG Y. P, Chessa, B., Chessa Bernardo, Mura Manuela, Alberto Alberti, Roman Biek, Varela Mariana, Leymaster Kreg, Spencer, Thomas,, ARNAUD F, BIEK R, Varela, Mariana, YU L, Golder Matthew, PALMARINI M., Chessa, Bernardo, Palmarini Massimo, Spencer, Thomas E., Manuela Mura, Biek, Roman, Spencer, Thomas E, DeMartini, James C., Leymaster, K., Filipe Pereira, Marco Caporale, Massimo Palmarini, Demartini, James, Demartini, James C, GOLDER M, DeMartini James C, Malim, Michael H, Yu, L., VARELA M, Caporale, Marco, Zhang Ya-ping, MURA M, DEMARTINI J. C, Alberti, Alberto   +78 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Determinants of hepatitis C virus clinical outcomes [PDF]

Hepatitis C VIruS (HCY) infection is characterized by a broad spectrum of clinical outcomes. An estimated 14%-46% of individuals exposed to HCY are able to clear the virus, while the other portion develops chronic ...
Yee, Leland Jonathan
core   +1 more source