Results 81 to 90 of about 269,778 (316)

Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. [PDF]

, 2012
The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation.
Cheng, Y, Richard Gilson, Singh, HD, Nebbia Gaia, Dusheiko, G., William Rosenberg, Peppa, D, Cheng, Y., Geoffrey Dusheiko, Cheng Yang, Joanne ChinAleong, ChinAleong, J, Patrick Kennedy, Dusheiko Geoffrey, Maini Mala K., Singh Harsimran D., Pooja Khanna, Maini, MK, Nebbia, G., Khanna, P, Gaia Nebbia (125377), Rosenberg, W, Rosenberg William, Rosenberg, W., Schurich, Anna; id_orcid, Gilson, R, ChinAleong Joanne, Mala K. Maini (125417), Patrick Kennedy (125414), Mala K Maini, Harsimran D Singh, Gilson Richard, ChinAleong, J., Gaia Nebbia, Harsimran D. Singh (125388), Nebbia, G, Khanna Pooja, Kennedy, P., Richard Gilson (125405), Schurich, A, Anna Schurich, Joanne ChinAleong (125409), Geoffrey Dusheiko (125400), Kennedy, P, Singh, H.D., Pooja Khanna (125385), William Rosenberg (14858), Khanna, P., Peppa Dimitra, Gilson, R., Kennedy Patrick, Yang Cheng (125394), Dusheiko, G, Dimitra Peppa, Dimitra Peppa (125379), Yang Cheng, Anna Schurich (125382), Maini, M.K., Peppa, D., Schurich Anna   +59 more
core   +1 more source

Effect of bovine leukemia virus (BLV) infection on bovine mammary epithelial cells RNA-seq transcriptome profile.

PLoS ONE, 2020
Bovine leukemia virus (BLV) is a δ-retrovirus responsible for Enzootic Bovine Leukosis (EBL), a lymphoproliferative disease that affects cattle. The virus causes immune system deregulation, favoring the development of secondary infections.
Lucia Martinez Cuesta, Juan Pedro Liron, María Victoria Nieto Farias, Guillermina Laura Dolcini, Maria Carolina Ceriani   +4 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

DETECTION OF EPSTEIN-BARR VIRUS GENOME IN ORAL CAVITY SQUAMOUS CELL CARCINOMA SAMPLES OF RUSSIAN PATIENTS

Вопросы вирусологии, 2019
Introduction. Oral cavity squamous cell carcinoma (OC-SCC) is the most common and aggressive malignancy of the oral cavity. Recent studies have revealed infections with human papilloma virus (HPV) as an additional risk factor for oral squamous cell ...
S. A. Kiryanov, T. A. Levina, A. P. Polyakov, I. V. Rebrikova, D. A. Murashko, M. V. Konopleva, T. A. Semenenko, A. P. Suslov   +7 more
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Oncolytic virotherapy – A novel strategy for cancer therapy

Egyptian Journal of Medical Human Genetics, 2018
Oncolytic virotherapy is a new modality of cancer treatment which uses competent replicating viruses to destroy cancer cells. This field progressed from earlier observations of accidental viral infections causing remission in many malignancies to virus ...
Mohanan Geetha Gopisankar, A. Surendiran
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Antinuclear antibodies (ANA) in chronic hepatitis C virus infection: correlates of positivity and clinical relevance.

, 2004
We examined correlates of antinuclear antibody (ANA) positivity (ANA+) in individuals with chronic hepatitis C virus (HCV) infection and the effect of positivity on clinical outcome of HCV. Pretreatment sera from 645 patients from three centres in Sweden
Marshall, S, Goldin, RD, A. Alberti, A. J. Hall, Yee, LJ, Thomas, HC, Thursz, MR, Chiaramonte, M, Braconier, J-H, Hall, AJ, L. J. Yee, H. C. Thomas, Braconier, Jean Henrik, R. D. Goldin, M. Chiaramonte, M. R. Thursz, S. Marshall, Kelleher, P, Braconier, Jean Henrik,, Alberti, A, Lund University., J.‐H. Braconier, P. Kelleher   +22 more
core   +1 more source

Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants. [PDF]

, 2010
BACKGROUND: Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are persistent herpesviruses that have various immunomodulatory effects on their hosts. Both viruses are usually acquired in infancy in Sub-Saharan Africa, a region where childhood vaccines ...
Ebrima S Touray, Whittle, H., Miles David J. C., Kaye, Steve, Melba S Palmero, Roberts, E., Ojuola, Olubukola, Miles, DJ, Palmero Melba S., Ojuola, O, Kaye Steve, Duah, NO, Mohammed, N.I., Cotten, M., Marianne van der Sande, Waight Pauline, Rowland-Jones, S., van der Sande, M, Cotten, M, Touay, Ebrima S., Holder, B., Cotten Matthew, Mohammed, NI, van der Sande Marianne, Whittle, H, Crozier, Sarah, Roberts, Elishia, Rowland-Jones, Sarah, Crozier, S., Miles, David J.C., Palmero, Melba S., Ojuola Olubukola, Waight, P., Touray, ES, Beth Holder, Roberts Elishia, Nuredin Ibrahim Mohammed, Nancy O Duah, Sarah Crozier, Touray, E.S., Hilton Whittle, Mohammed, Nuredin Ibrahim, Elishia Roberts, Sarah Rowland-Jones, Ebrima S. Touray, Touray, Ebrima S, van der Sande, M., Nancy O. Duah, Matthew Cotten, Whittle Hilton, Miles, David J C, Steve Kaye, Miles, David JC, van der Sande, Marianne, Kaye, S, Ojuola, O., David J C Miles, Mohammed Nuredin Ibrahim, Holder Beth, Palmero, M.S., Duah Nancy O., Melba S. Palmero, Cotten, Matthew, Duah, Nancy O, Palmero, Melba S, Whittle, Hilton, Miles, DJC, Rowland-Jones Sarah, Miles, D.J., Kaye, S., Holder, B, Olubukola Ojuola, David J. C. Miles, Touray Ebrima S., Duah, Nancy O., Palmero, MS, Duah, N.O., Waight, Pauline, Roberts, E, Rowland-Jones, S, Holder, Beth, Waight, P, Crozier, S, Pauline Waight, Crozier Sarah   +84 more
core   +1 more source