Results 91 to 100 of about 269,778 (316)

Severe invasive infections linked to IRAK2 immune variants

International Journal of Infectious Diseases
In subjects with peculiar susceptibility to severe infections by common pyogenic bacteria, mutations of interleukin-1 receptor-associated kinase proteins (IRAK)1 and IRAK4 had been identified.
Aseervatham Anusha Amali, Kathirvel Paramasivam, Sharada Ravikumar, Zhaohong Tan, Shaun Seh Ern Loong, Kelvin Han Chung Chong, Alicia Ang, Jin Zhu, Suma Sathyanarayana Rao, Louis Yi Ann Chai   +9 more
doaj   +1 more source

Detection of HBV Genotypes of Tumor Tissues and Serum by A Fluorescence Polarization Assay in North-Western China's Hepatocellular Carcinoma Patients

Virology Journal, 2011
Background The understanding of the distribution of hepatitis B virus genotypes and the occult hepatitis B virus infection in hepatocellular carcinoma may shed light into the prevention and treatment of hepatocellular carcinoma.
Liang Ping, Wang Xiangling, Li Ding, Cheng Hong, Wu Zhiqun, Gong Weidong, Lu Jianguo, Zhang Ju   +7 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Rescue of a genotype 4 human hepatitis E virus from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs [PDF]

, 2012
Hepatitis E virus (HEV) is an important but extremely understudied human pathogen. Genotypes 1 and 2 are restricted to humans, whereas genotypes 3 and 4 are zoonotic, infecting both humans and pigs.
Meng, Xiang-Jin, Feagins, Alicia R, Huang, Yao-Wei, Córdoba, Laura, Dryman, Barbara A, Opriessnig, Tanja, Cossaboom, Caitlin M   +6 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Adjuvance of influenza virosomes in CTL induction in vitro [PDF]

, 2005
The induction of cytotoxic T lymphocyte (CTL) responses is of high relevance in immunological defense against intracellular pathogens and tumor cells.
Schumacher, Reto
core   +1 more source

Tumor dynamics model with treatments by oncolytic virotherapy and MEK inhibitors involving TNF-α inhibitors: Stability analysis and optimal control

Computational and Mathematical Biophysics
Oncolytic virotherapy is one of the cancer treatments that kills cancer cells but leaves normal cells. Furthermore, mitogen-activated protein kinase (MEK) inhibitors boost chimeric antigen receptor expression and increase oncolytic virus entry into tumor
Daengkongkho Salinthip, Viriyapong Ratchada   +1 more
doaj   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Estudo in vitro das citocinas envolvidas na resposta inflamatória de macrófagos murinos à infecção pelo vírus da dengue. [PDF]

, 2012
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.A dengue é uma doença que tem como agente etiológico o Dengue virus (DENV), da família Flaviviridae, do gênero Flavivirus.
Souza, Ingrid Larissa Melo de
core  

BKV Agnoprotein Interacts with α-Soluble N-Ethylmaleimide-Sensitive Fusion Attachment Protein, and Negatively Influences Transport of VSVG-EGFP [PDF]

, 2011
Background: The human polyomavirus BK (BKV) infects humans worldwide and establishes a persistent infection in the kidney. The BK virus genome encodes three regulatory proteins, large and small tumor-antigen and the agnoprotein, as well as the capsid ...
Johannessen, M., Mona Johannessen, Walquist, Mari, Moens, Ugo, Walquist Mari, Spang Anne, Mari Walquist, Moens Ugo, Anne Spang, Gerits, N., Spang, Anne, Johannessen, Mona, Marte Dragset, Gerits Nancy, Johannessen Mona, Nancy Gerits, Ugo Moens, Dragset Marte, Walquist, M., Gerits, Nancy, Dragset, Marte Singsås, Dragset, M., Spang, A., Moens, U.   +23 more
core   +1 more source