Results 71 to 80 of about 269,778 (316)

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A.   +24 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Inducible nitric oxide synthase gene (NOS2A) haplotypes and the outcome of hepatitis C virus infection.

, 2004
Inducible nitric oxide synthase (iNOS) is an important molecule involved in the host defense against infectious agents. iNOS is encoded by the NOS2A gene and well-defined haplotypes exist with respect to this gene.
Hennig, BJW, Hill, Adrian, Knapp, S, Burgner, D, Hill, AVS, Yee, LJ, Thomas, HC, Frodsham, A J, Thursz, MR, Thomas, H C, Hennig, BJ, Hill, A V S, Frodsham, AJ, Thursz, M R, Hennig, B J W, Yee, L J, Wright, M   +16 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Phocine distemper Virus : current knowledge and future directions [PDF]

, 2014
Phocine distemper virus (PDV) was first recognized in 1988 following a massive epidemic in harbor and grey seals in north-western Europe. Since then, the epidemiology of infection in North Atlantic and Arctic pinnipeds has been investigated.
Baker, Jd, Groch, Kátia, Jensen, Brenda, Goldstein, T, Wellehan, James, Duprex, Wp, Kátia Groch, Nielsen, Ole, Rotstein, David, Tracey Goldstein, Michelle Barbieri, Van Bressem, M.-F., Lamy, Karina, Jeremy T. Saliki, Van Bressem, Marie-Françoise, W. Paul Duprex, Sylvain De Guise, Waltzek, T, Groch, K.R., Matassa, K, Marie-Françoise Van Bressem, Kátia R. Groch, Goodman, S.J., Morris, S.E., Duignan, Pj, de Swart, Rl, Dobson, A, Gulland, F, Early, G.A., Frances Gulland, Morris, Se, Mazzariol, S., Nielsen, O., Barbieri, Michelle, Duprex, W.P., Hall, A, Siebert, Ursula, Waltzek, T., Siebert, U, Sinead Morris, Simon J. Goodman, Dobson, A., Marie Françoise Van Bressem, Colegrove, K.M., De Guise, Sylvain, Fauquier, D., Morris, Sinead, Rowles, Teresa, Deborah Fauquier, Goodman, Sj, Baker, J.D., Van Bressem, Mf, Goldstein, T., Andrew Dobson, Jason D. Baker, Barbieri, M., Jensen, B.A., Goodman, Simon, Gulland, Frances, Groch, Kr, Thomas Waltzek, Karina Lamy, Ursula Siebert, MAZZARIOL, SANDRO, James Wellehan, Kathleen M. Colegrove, Ole Nielsen, Pádraig J. Duignan, Bryan Grenfell, Rik de Swart, Rotstein, D., De Guise, S, Sinead E. Morris, Pádraig Duignan, Brenda Jensen, Dobson, Andrew P., Lamy, K, Matassa, Keith, Jeremy Saliki, de Swart, R.L., Duignan, Pádraig, Nielsen, O, Colegrove, Kathleen, Fauquier, Deborah, Siebert, U., Early, G., Early, G, di Guardo, G., Wellehan, J.F.X., Greg Early, Wellehan, Jf, Waltzek, Thomas, Hall, A., Jensen, Ba, Jason Baker, DI GUARDO, Giovanni, Simon Goodman, Wellehan, J.F., de Swart, Rik, W. Duprex, Barbieri, M, Goldstein, Tracey, Gulland, F., Ailsa Hall, Colegrove, Km, Brenda A. Jensen, Grenfell, B., Teresa Rowles, Kathleen Colegrove, David Rotstein, Keith Matassa, Giovanni Di Guardo, Early, Greg, Grenfell, Bryan T., Duignan, P.J., Rik L. de Swart, Teresa K. Rowles, Duprex, W. Paul, Grenfell, B, Saliki, Jeremy, Rowles, T.K., Fauquier, D, Rowles, Tk, Lamy, K., Saliki, J.T., Matassa, K., James F.X. Wellehan, Hall, Ailsa, Baker, Jason, Sandro Mazzariol, Rotstein, D, Mazzariol, S, Saliki, Jt, de Guise, S.   +133 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source