Results 241 to 250 of about 527,270 (344)

Genomic Deletion of PFKFB3 Decreases In Vivo Tumorigenesis [PDF]

Yoannis Imbert-Fernandez, Simone Chang, Lilibeth Lanceta, Nicole M. Sanders, Jason Chesney, Brian F. Clem, Sucheta Telang   +6 more
openalex   +1 more source

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

Neuro-oncological ventral antigen 1 regulates liver cancer stem cell properties and Lenvatinib resistance via targeting SOX4. [PDF]

Cancer Cell Int
Lan H, Sun MM, Zhou PS, Liu XY, Wei WY, Lu K, Yang LX.   +6 more
europepmc   +1 more source

The role of RNA editing in cancer development and metabolic disorders [PDF]

, 2018
Kung, Che-Pei, Maggi, Leonard B, Jr., Weber, Jason D   +2 more
core   +2 more sources

Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis

Advanced Science, EarlyView.
Doppel protein is selectively expressed in tip endothelial cells within the tumor vasculature, where it promotes tip cell motility and stabilizes the tip cell phenotype. Targeting Doppel with monoclonal antibodies disrupts this stabilization, impairs angiogenic sprouting, and reduces tumor angiogenesis, offering a selective and druggable switch for ...
Byoungmo Kim, Ha Kyeong Lee, Zulfikar Azam, Jeong Uk Choi, Riajul Wahab, Na Kyeong Lee, Yoon Gun Ko, So‐Young Choi, Se‐Ra Lee, Wan Seob Shim, Taeeung Kim, In‐San Kim, Farzana Alam, Sang Yoon Kim, Seong Who Kim, Youngro Byun, Taslim A Al‐Hilal   +16 more
wiley   +1 more source

Phenotypic and functional characteristics of pituitary adenoma stem cells. [PDF]

World J Clin Cases
Agosti E, Gelmini L, Panciani PP, Fiorindi A, Fontanella MM, Tengattini F, Denaro L, Gagliano C, Tognetto D, Zeppieri M.   +9 more
europepmc   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Transposons disrupt genomic stability and trigger cancers. [PDF]

Front Cell Infect Microbiol
Dong W, Li M, Li P, Hou X, He F, Ji S.
europepmc   +1 more source

Autocrine Semaphorin 6B Signaling Is Essential for Tumorigenesis in Lung Cancer

Daisuke Yamada, Takuya Hasegawa, Kohichi Kawahara, Takehiko Maeda   +3 more
openalex   +2 more sources

Nfatc2 and Tob1 Have Non-Overlapping Function in T Cell Negative Regulation and Tumorigenesis

, 2014
Sarah May, Qing Zhou, Mitzi Lewellen, Cristan M. Carter, David G. Coffey, Steven L. Highfill, Christoph Bucher, Ilze Matise, Herbert C. Morse, Maeve O’Sullivan, Melissa M. Schutten, Charles S. Johnson, Donald Bellgrau, Bruce R. Blazar, Jaime F. Modiano   +14 more
openalex   +2 more sources