Results 21 to 30 of about 66,124 (248)
Molecular Therapy: Methods & Clinical Development, 2017 Human pluripotent stem cells (hPSCs) are a promising source of regenerative material for clinical applications. However, hPSC transplant therapies pose the risk of teratoma formation and malignant transformation of undifferentiated remnants.
Kaoru Mitsui +3 more
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Molecules, 2017 The use of human pluripotent stem cells (hPSCs) such as human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) in regenerative medicine is hindered by their tumorigenic potential.
Hiroaki Tateno +2 more
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Pharmaceuticals, 2021 Mesenchymal-stem/stromal-cell-derived small extracellular vesicles (MSC-sEV) have been shown to ameliorate many diseases in preclinical studies. However, translating MSC-sEV into clinical use requires the development of scalable manufacturing processes ...
Thong Teck Tan +5 more
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Frontiers in Cell and Developmental Biology, 2021 Our studies have demonstrated that cell tumorigenicity and pluripotent differentiation potential stem from neural stemness or a neural ground state, which is defined by a regulatory network of higher levels of machineries for basic cell physiological ...
Xiaoli Yang +16 more
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Cancer Stem Cell Functions in Hepatocellular Carcinoma and Comprehensive Therapeutic Strategies
Cells, 2020 Hepatocellular carcinoma (HCC) is a significant cause of cancer-related mortality owing to resistance to traditional treatments and tumor recurrence after therapy, which leads to poor therapeutic outcomes.
Yu-Chin Liu +2 more
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Cancer Management and Research, 2020 Feng Rong, Liang Liu, Can Zou, Jing Zeng, Yasheng Xu Department of Respiratory, Xiantao First People’s Hospital Affiliated to Changjiang University, Xiantao, Hubei, People’s Republic of ChinaCorrespondence: Yasheng Xu Tel +86 728-3220705Email
Rong F, Liu L, Zou C, Zeng J, Xu Y
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Emerging Microbes and Infections, 2022 Hepatitis B virus (HBV) exists as quasispecies (QS). However, the evolutionary characteristics of haplotypes of HBV X gene in the hepatocellular carcinoma (HCC) microenvironment remain unclear. Mutations across X gene are essential for the tumorigenicity
Ya Fu +12 more
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The prognostic role and metabolic function of GGPS1 in oral squamous cell carcinoma
Frontiers in Molecular Biosciences, 2023 Background: GGPS1(geranylgeranyl diphosphate synthase 1) is a member of the prenyltransferase family. Abnormal expression of GGPS1 can disrupt the balance between protein farnesylation and geranylgeranylation, thereby affecting a variety of cellular ...
Ke Huang +7 more
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Novel miR-5088-5p promotes malignancy of breast cancer by inhibiting DBC2
Molecular Therapy: Nucleic Acids, 2021 Breast cancer is the most common female cancer in the world. Despite the active research on metastatic breast cancer, the treatment of breast cancer patients is still difficult because the mechanism is not well known.
Hyun Jeong Seok +7 more
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The Role of HER2 in Self-Renewal, Invasion, and Tumorigenicity of Gastric Cancer Stem Cells
Frontiers in Oncology, 2020 BackgroundDeregulation of HER2 expression could affect the biological characteristics of gastric cancer cells and treatment option for gastric cancer patients.
Li-Fei Sun +10 more
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