Results 11 to 20 of about 7,025 (165)

Transcriptome-Wide Association Uncovers LncRNAs Controlling Seed Weight in Soybean. [PDF]

Adv Sci (Weinh)
This study employs transcriptome‐wide association studies (TWAS) to identify 201 long non‐coding RNAs (lncRNAs) associated with seed weight. Expression quantitative trait locus (eQTL) analysis reveals dynamic and static regulatory variants controlling lncRNA expression across development.
Wang X, Jiang X, Yuan X, Zhou Z, Zhao Z, Wang L, Jiao W, Ye W, Song Q.   +8 more
europepmc   +2 more sources

Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis

Arthritis Research & Therapy, 2021
Objective To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. Methods A transcriptome-wide association study (TWAS) was conducted by
Cuiyan Wu, Sijian Tan, Li Liu, Shiqiang Cheng, Peilin Li, Wenyu Li, Huan Liu, Feng’e Zhang, Sen Wang, Yujie Ning, Yan Wen, Feng Zhang   +11 more
doaj   +1 more source

Integrating transcriptome-wide association study and mRNA expression profile identified candidate genes related to hand osteoarthritis

Arthritis Research & Therapy, 2021
Background Osteoarthritis (OA) is a common skeletal system disease that has been partially attributed to genetic factors. The hand is frequently affected, which seriously affects the patient’s quality of life.
Jiawen Xu, Yi Zeng, Haibo Si, Yuan Liu, Mingyang Li, Junfeng Zeng, Bin Shen   +6 more
doaj   +1 more source

SUMMIT: An integrative approach for better transcriptomic data imputation improves causal gene identification

Nature Communications, 2022
Genes with moderate-low expression heritability cannot be sufficiently captured with conventional TWAS. This study introduces a new method, Summary-level Unified Method for Modeling Integrated Transcriptome (SUMMIT), to improve the expression prediction ...
Zichen Zhang, Ye Eun Bae, Jonathan R. Bradley, Lang Wu, Chong Wu   +4 more
doaj   +1 more source

Microstructure and Flight Behaviors of Droplet and its Solidification in Twin-Wire Arc Sprayed Ni-Al Composite Coatings [PDF]

Materials Research, 2018
Droplet flight and solidification behaviors during twin-wire arc sprayed (TWAS) composite coatings were systematically investigated. Both theoretical model and numerical method were established for calculating the droplet deformation, breakup and ...
Jixiao Wang, Yongdong Wang, Jingshun Liu, Lunyong Zhang, Limin Gao, Guanghai Zheng, Hongxian Shen, Jianfei Sun   +7 more
doaj   +2 more sources

Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis

Arthritis Research & Therapy, 2023
Background Osteoarthritis (OA) is a common degenerative joint disease and causes chronic pain and disability to the elderly. Several risk factors are involved, such as aging, obesity, genetic susceptibility, and environmental factors.
Lin Mei, Zhiming Zhang, Ruiqi Chen, Zhongyue Liu, Xiaolei Ren, Zhihong Li   +5 more
doaj   +1 more source

Integrative Transcriptome-Wide Analyses Uncover Novel Risk-Associated MicroRNAs in Hormone-Dependent Cancers

Frontiers in Genetics, 2021
BackgroundHormone-dependent cancers (HDC) are among the leading causes of death worldwide among both men and women. Some of the established risk factors of HDC include unhealthy lifestyles, environmental factors, and genetic influences.
Dulari K. Jayarathna, Dulari K. Jayarathna, Miguel E. Rentería, Miguel E. Rentería, Adil Malik, Adil Malik, Emilie Sauret, Jyotsna Batra, Jyotsna Batra, Neha S. Gandhi, Neha S. Gandhi   +10 more
doaj   +1 more source

TWAS revealed significant causal loci for milk production and its composition in Murrah buffaloes

Scientific Reports, 2023
Milk yield is the most complex trait in dairy animals, and mapping all causal variants even with smallest effect sizes has been difficult with the genome-wide association study (GWAS) sample sizes available in geographical regions with small livestock ...
Supriya Chhotaray, Vikas Vohra, Vishakha Uttam, Ameya Santhosh, Punjika Saxena, Rajesh Kumar Gahlyan, Gopal Gowane   +6 more
doaj   +1 more source

Identification of candidate genes and pathways associated with juvenile idiopathic arthritis by integrative transcriptome-wide association studies and mRNA expression profiles

Arthritis Research & Therapy, 2023
Aim Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood, with genetic susceptibility and pathological processes such as autoimmunity and autoinflammation, but its pathogenesis is unclear.
Ruoyang Feng, Mengnan Lu, Chunyan Yin, Ke Xu, Lin Liu, Peng Xu   +5 more
doaj   +1 more source

Supplemental Sewage Scum and Organic Municipal Solid Waste Addition to the Anaerobic Digestion of Thickened Waste Activated Sludge: Biomethane Potential and Microbiome Analysis

Fermentation, 2023
Sewage scum (SS) is collected from sedimentation tanks in wastewater treatment plants (WWTPs). Despite its huge biogas potential, there is limited information on its potential as a co-substrate and microbial ecology, especially during anaerobic co ...
Adewale Aromolaran, Majid Sartaj, Mohamed Abdallah   +2 more
doaj   +1 more source