Results 11 to 20 of about 57,499 (251)

Transcriptome-Wide Association Supplements Genome-Wide Association in Zea mays [PDF]

G3: Genes, Genomes, Genetics, 2019
Modern improvement of complex traits in agricultural species relies on successful associations of heritable molecular variation with observable phenotypes. Historically, this pursuit has primarily been based on easily measurable genetic markers.
Karl A. G. Kremling, Christine H. Diepenbrock, Michael A. Gore, Edward S. Buckler, Nonoy B. Bandillo   +4 more
doaj   +4 more sources

FarmGTEx TWAS-server: An Interactive Web Server for Customized TWAS Analysis [PDF]

Genomics, Proteomics & Bioinformatics
Abstract Transcriptome-wide association study (TWAS) is a powerful approach for investigating the molecular mechanisms linking genetic loci to complex phenotypes. However, the complexity of the TWAS analytical pipeline, including the construction of gene expression reference panels, gene expression prediction, and association analysis ...
Zhenyang Zhang, Zitao Chen, Jinyan Teng, Shuli Liu, Qing Lin, Jun Wu, Yahui Gao, Zhonghao Bai, Lingzhao Fang, Zhonghao Bai, Zhe Zhang, Jinyan Teng, Qing Lin, Jun Wu, Zhenyang Zhang, Zitao Chen, Qishan Wang, Yuchun Pan, Shuli Liu, George Liu, Yahui Gao, Bingjie Li, Bingjie Li, George Liu, Zhe Zhang, Yuchun Pan, Zhe Zhang, Lingzhao Fang, Qishan Wang   +28 more
openaire   +3 more sources

Population-Matched Transcriptome Prediction Increases TWAS Discovery and Replication Rate

iScience, 2020
Summary: Most genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS) focus on European populations; however, these results cannot always be accurately applied to non-European populations due to genetic architecture ...
Elyse Geoffroy, Isabelle Gregga, Heather E. Wheeler   +2 more
doaj   +3 more sources

Transcriptome-Wide Association Studies and Integration Analysis of mRNA Expression Profiles Identify Candidate Genes and Pathways Associated With Ankylosing Spondylitis

Frontiers in Immunology, 2022
This study aimed to identify susceptibility genes and pathways associated with ankylosing spondylitis (AS) by integrating whole transcriptome-wide association study (TWAS) analysis and mRNA expression profiling data.
Ruoyang Feng, Mengnan Lu, Lin Liu, Ke Xu, Peng Xu   +4 more
doaj   +1 more source

High-Throughput Screen of NPQ in Sorghum Shows Highly Polygenic Architecture of Photoprotection. [PDF]

Plant Environ Interact
ABSTRACT Natural genetic variation in photosynthesis and photoprotection within crop germplasm represents an untapped resource for crop improvement. Sorghum bicolor (sorghum) is one of the world's most widely grown crops, yet the genetic basis of photoprotection in sorghum is not well understood.
Vath RL, Fernandes SB, Monier B, Głowacka K, Walter J, Lipka AE, Ferguson J, Bernacchi CJ, Pederson T, Kromdijk J.   +9 more
europepmc   +2 more sources

A transcriptome-wide association study of uterine fibroids to identify potential genetic markers and toxic chemicals.

PLoS ONE, 2022
Uterine fibroid is one of the most prevalent benign tumors in women, with high socioeconomic costs. Although genome-wide association studies (GWAS) have identified several loci associated with uterine fibroid risks, they could not successfully interpret ...
Gayeon Kim, Gyuyeon Jang, Jaeseung Song, Daeun Kim, Sora Lee, Jong Wha J Joo, Wonhee Jang   +6 more
doaj   +2 more sources

Genomic Structural Equation Modeling Combined With Post-GWAS Analysis Identifies Two Risk Gene Loci and Functionally Sensitive Genes Associated With Cardiac Conduction Block. [PDF]

Genet Res (Camb)
Background Cardiac conduction disorders (CCDs) represent a broad spectrum of severe cardiovascular conditions associated with syncope and sudden cardiac death. Therefore, identification of reliable biomarkers is necessary to significantly improve the diagnostic accuracy and therapeutic outcomes of CCDs. This study analyzed GWAS summary datasets using a
Wang T, Miao X, Xia Y.
europepmc   +2 more sources

Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults.

PLoS Genetics, 2021
As a type of relatively new methodology, the transcriptome-wide association study (TWAS) has gained interest due to capacity for gene-level association testing.
Binglan Li, Yogasudha Veturi, Anurag Verma, Yuki Bradford, Eric S Daar, Roy M Gulick, Sharon A Riddler, Gregory K Robbins, Jeffrey L Lennox, David W Haas, Marylyn D Ritchie   +10 more
doaj   +1 more source

L3MBTL2 as a novel therapeutic target for trigeminal neuralgia: evidence from integrated TWAS, multi-tissue MR, and experimental validation. [PDF]

J Headache Pain
Wang H, Huang M, Huang Y, Hu K, Huang Y, Liang T, Yao J.   +6 more
europepmc   +3 more sources

Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia.

PLoS Genetics, 2021
Transcriptome-wide association studies (TWAS) have been widely used to integrate transcriptomic and genetic data to study complex human diseases. Within a test dataset lacking transcriptomic data, traditional two-stage TWAS methods first impute gene ...
Shizhen Tang, Aron S Buchman, Philip L De Jager, David A Bennett, Michael P Epstein, Jingjing Yang   +5 more
doaj   +1 more source