Results 21 to 30 of about 57,499 (251)

On the interpretation of transcriptome-wide association studies.

PLoS Genetics, 2023
Transcriptome-wide association studies (TWAS) aim to detect relationships between gene expression and a phenotype, and are commonly used for secondary analysis of genome-wide association study (GWAS) results.
Christiaan de Leeuw, Josefin Werme, Jeanne E Savage, Wouter J Peyrot, Danielle Posthuma   +4 more
doaj   +1 more source

Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies.

PLoS Genetics, 2021
Transcriptome-wide association studies (TWAS) test the association between traits and genetically predicted gene expression levels. The power of a TWAS depends in part on the strength of the correlation between a genetic predictor of gene expression and ...
Helian Feng, Nicholas Mancuso, Alexander Gusev, Arunabha Majumdar, Megan Major, Bogdan Pasaniuc, Peter Kraft   +6 more
doaj   +1 more source

Power analysis of transcriptome-wide association study: Implications for practical protocol choice.

PLoS Genetics, 2021
The transcriptome-wide association study (TWAS) has emerged as one of several promising techniques for integrating multi-scale 'omics' data into traditional genome-wide association studies (GWAS).
Chen Cao, Bowei Ding, Qing Li, Devin Kwok, Jingjing Wu, Quan Long   +5 more
doaj   +1 more source

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head

Frontiers in Genetics, 2021
ObjectiveThis study aims to identify novel candidate genes associated with osteonecrosis of the femoral head (ONFH).MethodsA transcriptome-wide association study (TWAS) was performed by integrating the genome-wide association study dataset of ...
Mei Ma, Peilin Li, Li Liu, Shiqiang Cheng, Bolun Cheng, Chu Jun Liang, Sijia Tan, Wenyu Li, Yan Wen, Xiong Guo, Cuiyan Wu   +10 more
doaj   +1 more source

Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis

Arthritis Research & Therapy, 2021
Objective To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. Methods A transcriptome-wide association study (TWAS) was conducted by
Cuiyan Wu, Sijian Tan, Li Liu, Shiqiang Cheng, Peilin Li, Wenyu Li, Huan Liu, Feng’e Zhang, Sen Wang, Yujie Ning, Yan Wen, Feng Zhang   +11 more
doaj   +1 more source

Transcriptome-wide association study identifies new susceptibility genes and pathways for spondyloarthritis

Journal of Orthopaedic Surgery and Research, 2023
Background Spondyloarthritis (SpA) is a group of multifactorial bone diseases influenced by genetic factors, the environment and lifestyle. However, current studies have found a limited number of SpA-related genes, and the genetic and pathogenic ...
Xiaochen Su, Anfa Chen, Menghao Teng, Wenchen Ji, Yingang Zhang   +4 more
doaj   +1 more source

Integrating transcriptome-wide association study and mRNA expression profile identified candidate genes related to hand osteoarthritis

Arthritis Research & Therapy, 2021
Background Osteoarthritis (OA) is a common skeletal system disease that has been partially attributed to genetic factors. The hand is frequently affected, which seriously affects the patient’s quality of life.
Jiawen Xu, Yi Zeng, Haibo Si, Yuan Liu, Mingyang Li, Junfeng Zeng, Bin Shen   +6 more
doaj   +1 more source

Identifying celiac disease-related chemicals by transcriptome-wide association study and chemical-gene interaction analyses

Frontiers in Genetics, 2022
Celiac disease (CeD) is one of the most common intestinal inflammatory diseases, and its incidence and prevalence have increased over time. CeD affects multiple organs and systems in the body, and environmental factors play a key role in its complex ...
Mengnan Lu, Ruoyang Feng, Yuesheng Liu, Yujie Qin, Hongyang Deng, Yanfeng Xiao, Chunyan Yin   +6 more
doaj   +1 more source

Additional TWA members? [PDF]

Astronomy & Astrophysics, 2002
4 (journal) pages, 3 figures, accepted in A&A. (US Letter size)
Song, Inseok, Bessell, Michael, Zuckerman, B   +2 more
openaire   +2 more sources

Microstructure and Flight Behaviors of Droplet and its Solidification in Twin-Wire Arc Sprayed Ni-Al Composite Coatings [PDF]

Materials Research, 2018
Droplet flight and solidification behaviors during twin-wire arc sprayed (TWAS) composite coatings were systematically investigated. Both theoretical model and numerical method were established for calculating the droplet deformation, breakup and ...
Jixiao Wang, Yongdong Wang, Jingshun Liu, Lunyong Zhang, Limin Gao, Guanghai Zheng, Hongxian Shen, Jianfei Sun   +7 more
doaj   +2 more sources