Results 31 to 40 of about 7,025 (165)

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 141 risk genes for Alzheimer’s disease dementia

Alzheimer’s Research & Therapy
Background Transcriptome-wide association study (TWAS) is an influential tool for identifying genes associated with complex diseases whose genetic effects are likely mediated through transcriptome.
Shuyi Guo, Jingjing Yang
doaj   +1 more source

Atomization Characteristics of Droplet and Morphologies of Arc Sprayed Ni-Al Particles and Composition Coatings [PDF]

Materials Research, 2019
Droplet atomization characteristics and its morphology in twin-wire arc sprayed (TWAS) Ni-Al were explored in depth. Both numerical model and theoretical method were built for calculating the process of the droplet deformation and breakup in air flow ...
Jixiao Wang, Jun Wang, Guo Jin, Li Wang, Caisong Mo, Li Ma, Bairu Li, Yongdong Wang, Hongxian Shen, Xing Lu, Yunzhuo Lv, Siyu Yuan, Jian Zhang, Yongjiang Huang, Fuyang Cao, Jianfei Sun   +15 more
doaj   +1 more source

From GWAS to Gene: Transcriptome-Wide Association Studies and Other Methods to Functionally Understand GWAS Discoveries

Frontiers in Genetics, 2021
Since their inception, genome-wide association studies (GWAS) have identified more than a hundred thousand single nucleotide polymorphism (SNP) loci that are associated with various complex human diseases or traits.
Binglan Li, Marylyn D. Ritchie, Marylyn D. Ritchie   +2 more
doaj   +1 more source

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou, Hao Jiang, Jingsheng Ruan, Daifeng Yang, Xing Chen, Shanshan Cai, Xinglin Yi   +6 more
wiley   +1 more source

Multi-context genetic modeling of transcriptional regulation resolves novel disease loci

Nature Communications, 2022
Transcriptome-wide association studies (TWAS) often ignore the specificity and sharing of effects across contexts (e.g., tissues). Here, the authors describe a method to split genetic effects into context-shared and context-specific terms.
Mike Thompson, Mary Grace Gordon, Andrew Lu, Anchit Tandon, Eran Halperin, Alexander Gusev, Chun Jimmie Ye, Brunilda Balliu, Noah Zaitlen   +8 more
doaj   +1 more source

Synthesis and Characterization of Citrus Reticulata Capped Ag–ZnO Nanoparticles: Effects of Growth Temperature

physica status solidi (a), EarlyView.
This research presents a facile green synthesis of silver doped zinc oxide nanoparticles using Citrus reticulata peel extract. The cost effective route was used to obtained nanoparticles at different growth temperatures and investigated their material properties for their potential application in solar cells due to their observed narrow bandgap of 2.84
Joan Jepngetich, Sharon Kiprotich, Peter W. Njoroge, Sylvia Opiyo, Francis B. Dejene   +4 more
wiley   +1 more source

Identification of Paramagnetic Centers in Irradiated F‐Doped Silica by First‐Principle Calculations

physica status solidi (a), EarlyView.
By means of first‐principle calculations of EPR parameters and energy barriers, two alternative structural models (2fSi‐F and E′F), which could explain the E′(F) center responsible for a 10.5 mT hyperfine doublet in irradiated F‐doped silica glass, are here investigated. Present results provide evidence in favor of the 2fSi‐F model.
Luigi Giacomazzi, Layla Martin‐Samos, Antonino Alessi   +2 more
wiley   +1 more source

Integrating transcriptome-wide study and mRNA expression profiles yields novel insights into the biological mechanism of chondropathies

Arthritis Research & Therapy, 2019
Background Chondropathies are a group of cartilage diseases, which share some common pathogenetic features. The etiology of chondropathies is still largely obscure now.
Ping Li, Yujie Ning, Xiong Guo, Yan Wen, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Sen Wang, Feng Zhang   +9 more
doaj   +1 more source

Thailand's Pursuit of Global Arboriculture: Worlding Aspirations and Introspective Learning for Urban Tree Care

Asia Pacific Viewpoint, EarlyView.
ABSTRACT Mobilising world‐leading expertise is crucial for addressing urban challenges. In recent years, Thai civic actors have introduced specialist arboricultural expertise to improve tree care practices in Bangkok and other Thai cities. However, despite adequate technical and administrative support, setbacks and conflicts emerged.
Chieh‐Ming Lai
wiley   +1 more source