Results 31 to 40 of about 57,499 (251)

Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis

Arthritis Research & Therapy, 2023
Background Osteoarthritis (OA) is a common degenerative joint disease and causes chronic pain and disability to the elderly. Several risk factors are involved, such as aging, obesity, genetic susceptibility, and environmental factors.
Lin Mei, Zhiming Zhang, Ruiqi Chen, Zhongyue Liu, Xiaolei Ren, Zhihong Li   +5 more
doaj   +1 more source

Ambient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity [PDF]

, 2017
JRS was supported by the 1000 talents program and a Wolfson merit award from the Royal Sociey.
Mazidi, Mohsen, Speakman, John R
core   +1 more source

Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution [PDF]

, 2017
We show that epigenome- and transcriptome-wide association studies (EWAS and TWAS) are prone to significant inflation and bias of test statistics, an unrecognized phenomenon introducing spurious findings if left unaddressed.
't Hoen, P.-B. (Peter-Bram), 't Hoen, P.A.C. (Peter A.C.), Arindrarto, W. (Wibowo), Beekman, M. (Marian), Berg, L.H. (Leonard) van den, Bonder, M.J. (Marc), Boomsma, D.I. (Dorret), Bot, J.J. (Jan), Breggen, R. (Ruud) van der, Deelen, J. (Joris), Deelen, P. (Patrick), Dijk, F. (Freerk) van, Dongen, J. (Jenny) van, Duijn, C.M. (Cornelia) van, Franke, L. (Lude), Greevenbroek, M.M. van, Heemst, D. (Diana) van, Heijmans, B.T. (Bastiaan), Hofman, B., Hottenga, J.J. (Jouke Jan), Isaacs, A.J. (Aaron), Iterson, M. (Maarten) van, Jansen, R., Jhamai, P.M. (Mila), Kallen, C.J. van der, Kielbasa, S.M. (Szymon M.), Lakenberg, N. (Nico), Luijk, R. (René), Mei, S. (Shan), Meurs, J.B.J. (Joyce) van, Moed, H. (Heleen), Nooren, I. (Irene), Pool, R. (Reńe), Rooij, J.G.J. (Jeroen) van, Schalkwijk, C.G. (Casper), Slagboom, P.E. (Eline), Stehouwer, C.D. (Coen), Suchiman, H.E.D. (Eka), Swertz, M.A. (Morris A.), Tigchelaar, E.F. (Ettje F.), Uitterlinden, A.G. (André), van 't Hof, P. (Peter), Van Galen, M. (Michiel), Veldink, J.H. (Jan), Verbiest, M.M.P.J. (Michael), Verkerk, M. (Marijn), Vermaat, M. (Martijn), Wijmenga, C. (Cisca), Zhernakova, A. (Alexandra), Zhernakova, S. (Sasha), Zwet, E.W. (Erik) van   +50 more
core   +1 more source

SUMMIT: An integrative approach for better transcriptomic data imputation improves causal gene identification

Nature Communications, 2022
Genes with moderate-low expression heritability cannot be sufficiently captured with conventional TWAS. This study introduces a new method, Summary-level Unified Method for Modeling Integrated Transcriptome (SUMMIT), to improve the expression prediction ...
Zichen Zhang, Ye Eun Bae, Jonathan R. Bradley, Lang Wu, Chong Wu   +4 more
doaj   +1 more source

TWAS revealed significant causal loci for milk production and its composition in Murrah buffaloes

Scientific Reports, 2023
Milk yield is the most complex trait in dairy animals, and mapping all causal variants even with smallest effect sizes has been difficult with the genome-wide association study (GWAS) sample sizes available in geographical regions with small livestock ...
Supriya Chhotaray, Vikas Vohra, Vishakha Uttam, Ameya Santhosh, Punjika Saxena, Rajesh Kumar Gahlyan, Gopal Gowane   +6 more
doaj   +1 more source

Identification of candidate genes and pathways associated with juvenile idiopathic arthritis by integrative transcriptome-wide association studies and mRNA expression profiles

Arthritis Research & Therapy, 2023
Aim Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood, with genetic susceptibility and pathological processes such as autoimmunity and autoinflammation, but its pathogenesis is unclear.
Ruoyang Feng, Mengnan Lu, Chunyan Yin, Ke Xu, Lin Liu, Peng Xu   +5 more
doaj   +1 more source

Integrative Transcriptome-Wide Analyses Uncover Novel Risk-Associated MicroRNAs in Hormone-Dependent Cancers

Frontiers in Genetics, 2021
BackgroundHormone-dependent cancers (HDC) are among the leading causes of death worldwide among both men and women. Some of the established risk factors of HDC include unhealthy lifestyles, environmental factors, and genetic influences.
Dulari K. Jayarathna, Dulari K. Jayarathna, Miguel E. Rentería, Miguel E. Rentería, Adil Malik, Adil Malik, Emilie Sauret, Jyotsna Batra, Jyotsna Batra, Neha S. Gandhi, Neha S. Gandhi   +10 more
doaj   +1 more source

De Rosis Nascentibus in English from the Renaissance to the Twentieth Century: a collection of translations [PDF]

, 2017
No abstract ...
Gillespie, Stuart
core   +1 more source

Supplemental Sewage Scum and Organic Municipal Solid Waste Addition to the Anaerobic Digestion of Thickened Waste Activated Sludge: Biomethane Potential and Microbiome Analysis

Fermentation, 2023
Sewage scum (SS) is collected from sedimentation tanks in wastewater treatment plants (WWTPs). Despite its huge biogas potential, there is limited information on its potential as a co-substrate and microbial ecology, especially during anaerobic co ...
Adewale Aromolaran, Majid Sartaj, Mohamed Abdallah   +2 more
doaj   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identified Candidate Genes and Pathways Associated With Acute Myocardial Infarction

Frontiers in Genetics, 2021
BackgroundAcute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive.MethodsA genome-wide association study dataset of AMI ...
Guanzhong Chen, Guanzhong Chen, Liwei Liu, Liwei Liu, Huanqiang Li, Zhubin Lun, Zhubin Lun, Ziling Mai, Ziling Mai, Wenguang Lai, Wenguang Lai, Enzhao Chen, Chunyun Zhou, Sijia Yu, Sijia Yu, Junqing Yang, Shiqun Chen, Jiyan Chen, Jiyan Chen, Jiyan Chen, Yong Liu, Yong Liu, Yong Liu   +22 more
doaj   +1 more source