Advances in Twin-Screw Granulation [PDF]
Pharmaceutics, 2021 Twin-screw granulation (TSG) is an emerging process technology that allows both wet and dry granulation of powders with a wide range of properties [...]
Valérie Vanhoorne, Ashish Kumar
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Pharmaceutics, 2021 Continuous twin screw wet granulation is one of the key continuous manufacturing technologies that have gained significant interest in the pharmaceutical industry as well as in academia over the last ten years.
Christoph Portier +2 more
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Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation [PDF]
PharmaceuticsBinder selection is a crucial step in continuous twin-screw wet granulation (TSWG), as the material experiences a much shorter residence time (2–40 s) in the granulator barrel compared to batch-wise granulation processes. Polyvinyl alcohol (PVA) 4-88 was
Phaedra Denduyver +4 more
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Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters [PDF]
PharmaceuticsHydroxypropyl methylcellulose (HPMC) is a preferred hydrophilic matrix former for controlled release formulations produced through continuous twin-screw wet granulation. However, a non-homogeneous API distribution over sieve fractions with underdosing in
Phaedra Denduyver +2 more
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A Material–Process–Equipment Integrated Design Method for Accelerating the Process Development of Twin-Screw Wet Granulation [PDF]
PharmaceuticalsBackground: Twin-screw wet granulation (TSWG) is a promising continuous manufacturing technology, featuring high operational flexibility, short residence time and consistent quality.
Liping Chen +9 more
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Development of a Rapid Method for Residence Time Distribution Measurement in Twin-Screw Wet Granulation Based on Image Processing with Lab Color Space [PDF]
PharmaceuticsBackground/Objectives: In the twin-screw wet granulation (TSWG) process, accurate measurement of residence time distribution (RTD) is critical, as it characterizes material transport kinetics and mixing behavior.
Jie Zhao +3 more
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Effect of Mixing Elements on Granule Formation in Hot Melt Twin Screw Granulation [PDF]
Chemical Engineering Transactions, 2021 Twin screw granulation (TSG) has been applied to wet granulation, although its application in melt granulation has been more limited. This work explores potential advantages of hot melt granulation using twin screw extrusion.
Nana Sekyi +2 more
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Material Transport Characteristics in Planetary Roller Melt Granulation [PDF]
Pharmaceutics, 2023 Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current
Tom Lang +3 more
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Investigating the Effects of Mixing Dynamics on Twin-Screw Granule Quality Attributes via the Development of a Physics-Based Process Map [PDF]
PharmaceuticsTwin-screw granulation (TSG) is an emerging continuous wet granulation technique that has not been widely applied in the industry due to a poor mechanistic understanding of the process.
Lalith Kotamarthy +4 more
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Emerging Technologies in Granulation: Process Analytical Technologies and Modeling Approaches in Pharmaceutical Development and Manufacturing [PDF]
PharmaceuticsIn the present review, 32 studies, published between 2020 and 2026, were reviewed to identify recent advances in pharmaceutical granulation. Emphasis is placed on the integration of real-time monitoring technologies, recent Process Analytical ...
Panagiotis Pentsis +3 more
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