Results 31 to 40 of about 707,579 (129)

Quantitative Assessment of Mass Flow Boundaries in Continuous Twin-screw Granulation

CHIMIA, 2016
In pharmaceutical manufacturing, there is an increasing interest in continuous manufacturing. As an example for fast continuous processes in general of considerable complexity, this study was focussed on improving the understanding of twin-screw
Adrian Schmidt, Hans de Waard, Klaus-Peter Moll, Markus Krumme, Peter Kleinebudde   +4 more
doaj   +1 more source

Twin Screw Granulation – A Literature Review [PDF]

, 2015
This review article addresses the currently available literature on Twin Screw Granulation (TSG). TSG is an emerging technology rapidly gaining interest in the pharmaceutical industry as a method of continuous wet granulation. The control of the geometry
Gabbott, Ian, De Matas, Marcel, Huang, Zhenyu, Rowson, Neil A., Reynolds, Gavin K., Ingram, Andrew, Chan Seem, Timothy, Yu, Shen   +7 more
core   +1 more source

TWIN SCREW GRANULATION: UNDERSTANDING THE MECHANICAL PROPERTIES OF PHARMACEUTICAL EXCIPIENTS FROM POWDER TO TABLET [PDF]

, 2018
The overall aim of this work is to understand the effect of the mechanical properties of the primary powder and the granulation process on granules and tablets properties, most importantly tablet tensile strength.
Khorsheed, Bilal
core   +4 more sources

Linking granulation performance with residence time and granulation liquid distributions in twin-screw granulation: An experimental investigation [PDF]

, 2016
Twin-screw granulation is a promising wet granulation technique for the continuous manufacturing of pharmaceutical solid dosage forms. A twin screw granulator displays a short residence time.
Remon, Jean Paul, De Beer, Thomas, Ketolainen, Jarkko, Vervaet, Chris, Gernaey, Krist V., Nopens, Ingmar, Vanhoorne, Valérie, De Leersnyder, Fien, Juuti, Mikko, Vercruysse, Jurgen, Kumar, Ashish, Alakarjula, Maija, Toiviainen, Maunu   +12 more
core   +1 more source

Mechanistic modeling of twin screw wet granulation for pharmaceutical formulations : calibration, sensitivity analysis, and model-driven workflow [PDF]

Wet granulation, a particle size enlargement process, can significantly enhance the critical quality attributes of powders and improve the ability to form tablets in pharmaceutical manufacturing.
Lee, Kai, Dawson, Neil, Iyer, Kiran, Schongut, Marek, Doshi, Pankaj, Ahmed, Bilal, Smith, Rachel M., Bala, Neeru, Corrigan, Jeremiah, Meyer, Jonathan, Rowland, Martin, Litster, James D.   +11 more
core   +4 more sources

Analysis of the Influence of Process and Formulation Properties on the Drying Behavior of Pharmaceutical Granules in a Semi-Continuous Fluid Bed Drying System

Powders, 2023
In the last decade, twin-screw wet granulation became an essential technology for continuous pharmaceutical tablet production. Consequently, interest in (semi-)continuous fluidized bed drying systems as a subsequent processing unit has grown. In parallel,
Tuur Vandeputte, Michael Ghijs, Michiel Peeters, Alexander De Man, Daan Van Hauwermeiren, Eduardo Dos Santos Schultz, Tamas Vigh, Fanny Stauffer, Ingmar Nopens, Thomas De Beer   +9 more
doaj   +1 more source

Wet Granulation in a Twin Screw Extruder [PDF]

, 2008
This thesis covers a systematic examination of wet granulation in a twin screw extruder. Granulation of the excipient, (alpha)-lactose monohydrate, was done with the aid of PVP in an aqueous solution which acted as a binding agent.
Sun, Junfeng
core   +1 more source

Continuous granulation

, 2021
This chapter discusses the continuous processing of pharmaceutical solid dosage forms, focusing on continuous wet granulation. Based on the advantages offered by continuous manufacturing, it highlights the drivers for the pharmaceutical industry to shift
Thomas De Beer, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie, Chris Vervaet, Valérie Vanhoorne   +5 more
core   +1 more source

Twin Screw Granulation: Effects of Properties of Primary Powders

Pharmaceutics, 2018
Lactose and mannitol are some of the most commonly used powders in the pharmaceutical industry. The limited research published so far highlights the effects of process and formulation parameters on the properties of the granules and the tablets produced ...
Sushma V. Lute, Ranjit M. Dhenge, Agba D. Salman   +2 more
doaj   +1 more source

Evaluation of Process Parameters for Continuous Manufacturing of Quetiapine Fumarate Immediate Release Tablets Using Twin Screw Wet Granulation. [PDF]

Pharm Res
Granulation is one of the important unit operations in the manufacturing of solid dosage forms like tablets and capsules that regulate the quality of end products.
Naguboyina T, Lakkala P, Munnangi SR, Vemula SK, Repka M.   +4 more
europepmc   +2 more sources