Results 21 to 30 of about 707,579 (129)

Systematic investigation of the impact of screw elements in continuous wet granulation [PDF]

International Journal of Pharmaceutics: X
Twin-screw wet granulation (TSG) is a continuous manufacturing technique either for granules as final dosage form or as an intermediate before tableting or capsule filling.
Katharina Kiricenko, Robin Meier, Peter Kleinebudde   +2 more
doaj   +2 more sources

Transitioning Amiodarone Tablet Manufacturing: A Comparative Study of Batch and Continuous Wet Granulation [PDF]

Pharmaceuticals
Background/Objectives: The objective of this study was to design and optimize a continuous wet granulation process for Amiodarone hydrochloride tablets using a Design of Experiments approach.
Ju-Hyun Yoon, Chae-Won Jeon, Joo-Eun Kim
doaj   +2 more sources

Twin Screw Wet Granulation With Various Hydroxypropyl Methylcellulose (HPMC) Grades [PDF]

, 2022
Twin screw wet granulation has been proved as a feasible alternative for traditional batch granulation process due to its continuous processing feature; considered as a significant processing method especially in the pharmaceutical industry.
Chen, Jingyi
core   +2 more sources

SCALE-UP OF PHARMACEUTICAL TWIN-SCREW WET GRANULATION BASED ON THE PROCESS SIMULATION USING GENETIC PROGRAMMING [PDF]

, 2023
Wet granulation is a crucial process in the manufacturing of pharmaceutical tablets. For several years, twin-screw wet granulation has been noticeably studied as a continuous method for granulation in the pharmaceutical industry because of its ability ...
Mozumder, Sumon
core   +2 more sources

Influence of the Feedstock Preparation on the Properties of Highly Filled Alumina Green-Body and Sintered Parts Produced by Fused Deposition of Ceramic

Ceramics, 2023
This paper investigates new approaches for the blending and plastification of ceramic powder with a binder to form fused deposition of ceramic (FDC) feedstock.
Thomas Heim, Frank Kern
doaj   +1 more source

A Semi-Mechanistic Prediction of Residence Time Metrics in Twin Screw Granulation

Pharmaceutics, 2021
This work is concerned with the semi-mechanistic prediction of residence time metrics using historical data from mono-component twin screw wet granulation processes.
Shashank Venkat Muddu, Lalith Kotamarthy, Rohit Ramachandran   +2 more
doaj   +1 more source

Understanding Scalability In A Twin Screw Wet Granulation [PDF]

, 2022
Continuous wet granulation using a twin-screw extruder has attracted considerable attentions in pharmaceutical industry as it ensures consistent tablet quality at a high production rate.
Shi, Zequn
core   +2 more sources

Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying – A QbD approach

International Journal of Pharmaceutics: X, 2021
Despite significant advances in the research domain of continuous twin screw granulation, limited information is currently available on the impact of raw material properties, especially considering batch-to-batch variability.
Christoph Portier, Tamas Vigh, Giustino Di Pretoro, Jan Leys, Didier Klingeleers, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne   +7 more
doaj   +1 more source

Conceptualisation of an Efficient Particle-Based Simulation of a Twin-Screw Granulator

Pharmaceutics, 2021
Discrete Element Method (DEM) simulations have the potential to provide particle-scale understanding of twin-screw granulators. This is difficult to obtain experimentally because of the closed, tightly confined geometry.
John P. Morrissey, Kevin J. Hanley, Jin Y. Ooi   +2 more
doaj   +1 more source

TWIN SCREW WET AND DRY GRANULATION [PDF]

, 2017
Twin screw granulation has gained wide interest by pharmaceutical manufacturing and the industry is still trying to expand its application. This thesis will further explore this technique and try to develop a new granulation strategy based on similar ...
Liu, Yang
core   +1 more source