Results 111 to 120 of about 28,841 (200)

Modulation of MnSOD and FoxM1 is Involved in Invasion and EMT Suppression by Isovitexin in Hepatocellular Carcinoma Cells [Retraction]

Cancer Management and Research, 2022
Qiu Y, Cao X, Liu L, et al. Cancer Manag Res. 2020;12:5759‒5771. The Editor and Publisher of Cancer Management and Research wish to retract the published article.
Qiu Y, Cao X, Liu L, Cao X, Yuan Q, Li X, Cui Y, Xu C, Zou C, Ren K, Cao J   +10 more
doaj  

The Level of TWIST1 expression determines the response of colon cancer cells to mitogen-activated protein kinases inhibitors

The Saudi Journal of Gastroenterology, 2018
Background/Aim: Currently, it has been proposed that combination of 5-fluorouracil (5FU) with inhibitors of the mitogen-activated protein kinases (MAPKs) signaling pathway might enhance the efficacy of 5FU-based chemotherapy in colon cancer.
Tomasz Przybyla, Martyna Wesserling, Monika Sakowicz-Burkiewicz, Izabela Maciejewska, Tadeusz Pawelczyk   +4 more
doaj   +1 more source

The Proto-Oncogene TWIST1 Is Regulated by MicroRNAs

PLoS ONE, 2013
Upregulation of the proto-oncogene Twist1 is highly correlated with acquired drug resistance and poor prognosis in human cancers. Altered expression of this multifunctional transcription factor is also associated with inherited skeletal malformations. The mammalian Twist1 3'UTRs are highly conserved and contain a number of potential regulatory elements
Nairismägi, Maarja-Liisa, Füchtbauer, Annette, Labouriau, Rodrigo, Bramsen, Jesper Bertram, Füchtbauer, Ernst-Martin   +4 more
openaire   +5 more sources

Senescence‐Driven IL‐17A Inflammatory Circuit Promotes Epithelial–Mesenchymal Transition (EMT) and Progression in Age‐Related Posterior Subcapsular Cataracts

Aging Cell, Volume 25, Issue 4, April 2026.
Using multi‐region human PSC samples, we identified EMT as a consistent pathological feature. Mechanistically, senescent LECs secrete IL‐17A, a representative SASP factor, which activates NF‐κB signaling. NF‐κB further amplifies SASP production, thereby establishing a senescence–inflammation feedback loop that drives EMT, sustains pathological ...
Yan Ni, Yu Ma, Zewen Ren, Yi Zhu, Liangping Liu, Runping Duan, Lu Qin, Yang Chen, Rong Ju, Yingyan Qin, Mingxing Wu   +10 more
wiley   +1 more source

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis [PDF]

, 2014
In this study we examine the consequences of altering Hand1 phosphoregulation in the developing neural crest cells (NCCs) of mice. Whereas Hand1 deletion in NCCs reveals a nonessential role for Hand1 in craniofacial development and embryonic survival ...
Clouthier, David E., Firulli, Anthony B., Firulli, Beth A., Fuchs, Robyn K., Vincentz, Joshua W.   +4 more
core   +1 more source

Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells [PDF]

, 2019
Metastatic competence of cancer cells is influenced by many factors including metabolic alterations and changes in mitochondrial biogenesis and protein homeostasis.
Daverey, Amita, Hayward, Stephen, Khalimonchuk, Oleh, Kidambi, Srivatsan, Levytskyy, Roman M., Narasimhan, Madhusudhanan, Ponte Viana, Martonio, Stanke, Kimberly M., Swenson, Samantha   +8 more
core   +1 more source

Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells. [PDF]

, 2017
β-catenin has two different cellular functions: intercellular adhesion and transcriptional activity. The E3 ubiquitin ligase Siah1 causes ubiquitin-mediated degradation of the cytosolic β-catenin and therefore, impairs nuclear translocation and oncogenic
Bhattacharyya, A, Crowe, SE, Das, L, Dixit, P, Kokate, SB, Rath, S, Rout, N, Singh, SP   +7 more
core   +1 more source

Twist1 promotes astrocytoma development by stimulating vasculogenic mimicry

Oncology Letters, 2019
Astrocytomas are one of the most vascularized types tumor in human cancers. Micro-vascular proliferation is an important factor for the classification of astrocytoma. Vasculogenic mimicry (VM) is a novel tumor vascular model that develops independently of endothelial cells, and serves an important role in astrocytoma.
Wei, Cao, Can, Xu, Xinxing, Li, Xianghong, Yang   +3 more
openaire   +3 more sources

Immortalization of T-cells is accompanied by gradual changes in CpG methylation resulting in a profile resembling a subset of T-cell leukemias [PDF]

, 2014
We have previously described gene expression changes during spontaneous immortalization of T-cells, thereby identifying cellular processes important for cell growth crisis escape and unlimited proliferation. Here, we analyze the same model to investigate
Borssén, Magnus, Chrzanowska, Krystyna H., Degerman, Sofie, Evelönn, Emma, Forestier, Erik, Keith, W. Nicol, Landfors, Mattias, Revie, John, Roos, Göran, Rydén, Patrik, Siwicki, Jan Konrad   +10 more
core   +1 more source