Results 91 to 100 of about 407,697 (279)

Coiled-Coil Antagonism Regulates Activity of Venus Flytrap-Domain-Containing Sensor Kinases of the BvgS Family

mBio, 2018
Bordetella pertussis controls the expression of its virulence regulon through the two-component system BvgAS. BvgS is a prototype for a family of multidomain sensor kinases.
Elodie Lesne, Elian Dupré, Marc F. Lensink, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Two-component signal transduction in Bacillus cereus and closely related bacteria [PDF]

, 2009
Bacillus cereus is a Gram-positive pathogen that is recognised as an important cause of food-borne disease worldwide. Within the genus Bacillus, B. cereus and its closest relatives form a homogeneous subdivision that has been termed the B.
Been, M.W.H.J., de, de Been, M.W.H.J.
core  

Regulatory analysis for the resolution of Generic Issue 143: Availability of chilled water system and room cooling [PDF]

, 1993
This report presents the regulatory analysis for Generic Issue (GI-143), {open_quotes}Availability of Chilled Water System and Room Cooling.{close_quotes} The heating, ventilating, and air conditioning (HVAC) systems and related auxiliaries are required ...
Leung, V. T.
core   +1 more source

Constitutive activation of two-component systems reveals regulatory network interactions in Streptococcus agalactiae

Nature Communications
Bacterial two-component systems (TCSs) are signaling modules that control physiology, adaptation, and host interactions. A typical TCS consists of a histidine kinase (HK) that activates a response regulator via phosphorylation in response to ...
Cosme Claverie, Francesco Coppolino, Maria-Vittoria Mazzuoli, Cécile Guyonnet, Elise Jacquemet, Rachel Legendre, Odile Sismeiro, Giuseppe Valerio De Gaetano, Giuseppe Teti, Patrick Trieu-Cuot, Asmaa Tazi, Concetta Beninati, Arnaud Firon   +12 more
doaj   +1 more source

A novel insight into ComE-mediated activation of gene expression in Streptococcus mutans

Microbiology Spectrum
Bacteria use two-component signal transduction systems (TCSs) to sense and respond to environmental changes. TCSs comprise a histidine kinase that senses environmental signals and a response regulator that regulates cognate promoters.
Hemendra Pal Singh Dhaked, Saswati Biswas, Indranil Biswas   +2 more
doaj   +1 more source

Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in Staphylococcus aureus

mBio, 2017
The SaeRS two-component system is a master activator of virulence factor transcription in Staphylococcus aureus, but the cellular factors that control its activity are unknown.
Megan E. Ericson, Chitra Subramanian, Matthew W. Frank, Charles O. Rock   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Six putative two-component regulatory systems isolated from Lactococcus lactis subsp. cremoris MG1363 [PDF]

, 2000
International audienceThe genetic elements specifying six putative two-component regulatory systems (2CSs) were identified on the chromosome of Lactococcus lactis MG1363.
van Sinderen, Douwe, Morel, Patrice, Fitzgerald, Gerald F., Morel Deville, Francoise, O'Connell-Motherway, Mary, Ehrlich, Dusko   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source