Results 81 to 90 of about 407,697 (279)

Using temporal correlation in factor analysis for reconstructing transcription factor activities [PDF]

, 2008
Two-level gene regulatory networks consist of the transcription factors (TFs) in the top level and their regulated genes in the second level. The expression profiles of the regulated genes are the observed high-throughput data given by experiments such ...
Wernisch, Lorenz, Lorenz Wernisch, Pournara, Iosifina, Iosifina Pournara   +3 more
core   +1 more source

A conserved two-component system senses intracellular iron levels and regulates redox balance in Mycobacterium spp.

Microbiology Spectrum
For bacteria, an intricate coordination between sensing and regulating iron levels and managing oxidative stress is required as their levels are tightly interlinked.
Rahul Yadav, Deepak Kumar Saini
doaj   +1 more source

Structural insights into the histidine-containing phosphotransfer protein and receiver domain of sensor histidine kinase suggest a complex model in the two-component regulatory system in Pseudomonas aeruginosa

IUCrJ, 2020
In Pseudomonas aeruginosa, an important opportunistic pathogen that causes numerous acute and chronic infections, the hybrid two-component system (TCS) regulates the swarming ability and biofilm formation with a multistep phosphorelay, and consists of ...
Shao-Kang Chen, Hong-Hsiang Guan, Pei-Hsun Wu, Li-Ting Lin, Meng-Chun Wu, Hwan-You Chang, Nai-Chi Chen, Chien-Chih Lin, Phimonphan Chuankhayan, Yen-Chieh Huang, Pei-Ju Lin, Chun-Jung Chen   +11 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The unique histidine kinase, AtcS, regulates motility and pathogenicity of the periodontal pathobiont, Treponema denticola

Infection and Immunity
Treponema denticola is an obligate colonizer of the human gingival crevice and, along with other pathobionts, is highly associated with the development of periodontal disease.
Doaa N. Abdallah, Annie N. Hinson, Aidan D. Moylan, Dhara T. Patel, Bin Zhu, Richard T. Marconi, Daniel P. Miller   +6 more
doaj   +1 more source

Regulation of Francisella tularensis Virulence

Frontiers in Cellular and Infection Microbiology, 2011
Francisella tularensis is one of the most virulent bacteria known and a Centers for Disease Control and Prevention Category A select agent. It is able to infect a variety of animals and insects and can persist in the environment, thus Francisella spp ...
Shipan eDai, Nrusingh P Mohapatra, Larry S Schlesinger, Larry S Schlesinger, Larry S Schlesinger, John S Gunn, John S Gunn, John S Gunn   +7 more
doaj   +1 more source

Inactivation of DNA-binding response regulator Sak189 abrogates beta-antigen expression and affects virulence of Streptococcus agalactiae. [PDF]

PLoS ONE, 2010
BACKGROUND: Streptococcus agalactiae is able to colonize numerous tissues employing different mechanisms of gene regulation, particularly via two-component regulatory systems.
Anastasia S Rozhdestvenskaya, Artem A Totolian, Alexander V Dmitriev   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Nuclear Regulatory Commission Report 4747 [PDF]

, 1988
Tables detailing aging tallies produced as part of the aging failure survey. The tables display the detailed breakdown for the data by component, system effect, failure category, and age of component at the time of failure. (p. E-3 of report)
Satterwhite, D. G., Meale, B. M.
core  

Uncovering the transcriptional control of "Bartonella henselae" host adaptation factors [PDF]

, 2014
A recurrent theme in bacterial pathogenicity is the understanding of the regulatory events necessary for a given pathogen to progress through its infection cycle while resisting the host defense mechanisms.
Québatte, Maxime
core   +1 more source