Mitochondrial neurogastrointestinal encephalomyopathy in china: a novel TYMP variant and comprehensive clinical-genetic insights [PDF]
Orphanet Journal of Rare DiseasesBackground Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is a rare autosomal recessive disorder caused by variants in the TYMP gene, which encodes thymidine phosphorylase (TP).
Lihong Yang, Junhui Xia, Xuebi Xu
exaly +3 more sources
Identifying TYMP as an Immune Prognostic Marker in Clear Cell Renal Cell Carcinoma
Technology in Cancer Research and Treatment, 2023 Background In clear cell renal cell carcinoma (ccRCC), only some patients can benefit from immunotherapy therapy, and it is urgent to find immune-related molecular markers and targets.
Shaoan Chen
exaly +2 more sources
Thymidine phosphorylase promotes SARS-CoV-2 spike protein-driven lung tumor development [PDF]
Frontiers in ImmunologyBackgroundCOVID-19 survivors exhibit increased interstitial lung fibrosis, a known risk factor for lung cancer. We investigated whether SARS-CoV-2 spike protein (SP)-induced lung injury and elevated thymidine phosphorylase (TYMP) promote lung ...
Cayleigh Wallace +6 more
doaj +2 more sources
Klf4-Tymp axis promotes inflammation-driven early tumorigenesis by enhancing kras mutation-induced acinar-to-ductal metaplasia through Pi3k/Akt and Mek/Erk pathways [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground Acinar-to-ductal metaplasia (ADM) is a pivotal step in pancreatic tumorigenesis, reversible in normal contexts but progressing to PanIN and pancreatic cancer (PC) in the presence of Kras mutation and inflammation.
Qihang Yuan +8 more
doaj +2 more sources
TYMP upregulation mediated by the hyperactivated IL-17/NF-κB1 axis promotes psoriasis through enhancing aberrant keratinization and neutrophil-mediated inflammation [PDF]
Biology DirectPsoriasis is a common, chronic, and recurrent immune-mediated disorder with global prevalence, underscoring the need for novel biomarkers to improve diagnosis and treatment.
Jing Wang +7 more
doaj +2 more sources
Association of a Homozygous TYMP c.131G>C Variant With MNGIE in a Chinese Pedigree: Insights From Genetic Analysis and Computational Modeling [PDF]
Molecular Genetics & Genomic MedicineBackground Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder caused by mutations in TYMP, which disrupt thymidine metabolism.
Ling Li +6 more
doaj +2 more sources
Frontiers in Genetics, 2020 Biallelic TYMP variants result in the mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), a juvenile-onset disorder with progressive course and fatal outcome. Milder late-onset (>40 years) form has been rarely described.
Francesca Tagliavini +2 more
exaly +3 more sources
Proteomic Profiling of Bone Marrow Aspirates from Patients with Methotrexate- and Vincristine-Resistant B-Cell Acute Lymphoblastic Leukemia: A Retrospective Analysis [PDF]
PharmaceuticalsBackground: B-cell acute lymphoblastic leukemia (B-ALL) is the most frequent malignancy of childhood; worldwide, 487,294 new cases and 305,405 deaths were reported in 2022, including more than 5000 new cases in Mexico.
Esli Janai Flores-Palma +11 more
doaj +2 more sources
Thymidine phosphorylase in nucleotide metabolism: physiological functions and its implications in tumorigenesis and anti-cancer therapy [PDF]
Frontiers in ImmunologyThymidine phosphorylase (TYMP), a protein found in both prokaryotic and eukaryotic cells, is encoded by a gene located in the q13 region of chromosome 22. With a relative molecular mass of 55,000, TYMP exists as a homodimer.
Bo Huang +5 more
doaj +2 more sources
Molecular Insights from Differential Proteomic Profiling of Premalignant Cervical Lesions and Cervical Cancer [PDF]
PathogensCervical cancer (CC) affects women worldwide, and more than 95% of cases are caused by persistent infection with high-risk human papillomavirus (HR-HPV), such as type 16, which promotes the progression of precancerous lesions to cancer.
Diana Laura Gonzalez-Tolentino +9 more
doaj +2 more sources