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The Lancet, 2023 Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β cells. Individuals with type 1 diabetes are reliant on insulin for survival.
Teresa Quattrin +2 more
semanticscholar +4 more sources
The Immunology of type 1 diabetes
Nature Reviews ImmunologyFollowing the seminal discovery of insulin a century ago, treatment of individuals with type 1 diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose dysregulation.
K. Herold +5 more
semanticscholar +4 more sources
Diabetologia, 2021 The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) convened a writing group to develop a consensus statement on the management of type 1 diabetes in adults.
R. Holt +13 more
semanticscholar +2 more sources
Inflammasomes and Type 1 Diabetes [PDF]
Frontiers in Immunology, 2021 Microbiota have been identified as an important modulator of susceptibility in the development of Type 1 diabetes in both animal models and humans. Collectively these studies highlight the association of the microbiota composition with genetic risk, islet autoantibody development and modulation of the immune responses.
James Alexander Pearson +2 more
openaire +3 more sources
The Lancet, 2018 Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden ...
DiMeglio, Linda A. +2 more
openaire +4 more sources
Frontiers in Endocrinology, 2023 ObjectiveEndoC-βH5 is a newly established human beta-cell model which may be superior to previous model systems. Exposure of beta cells to pro-inflammatory cytokines is widely used when studying immune-mediated beta-cell failure in type 1 diabetes.
Caroline Frørup +10 more
doaj +1 more source
Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells
Non-Coding RNA, 2022 Circular RNAs (circRNAs) have recently been implicated in impaired β-cell function in diabetes. Using microarray-based profiling of circRNAs in human EndoC-βH1 cells treated with pro-inflammatory cytokines, this study aimed to investigate the expression ...
Simranjeet Kaur +9 more
doaj +1 more source
The Lancet, 2014 Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge ...
Mark A, Atkinson +2 more
openaire +2 more sources
Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective.
Diabetes, 2022 Most screening programs to identify individuals at risk for type 1 diabetes have targeted relatives of people living with the disease to improve yield and feasibility.
E. Sims +17 more
semanticscholar +1 more source
Interpreting type 1 diabetes risk with genetics and single cell epigenomics
Nature, 2021 Genetic risk variants that have been identified in genome-wide association studies of complex diseases are primarily non-coding1. Translating these risk variants into mechanistic insights requires detailed maps of gene regulation in disease-relevant cell
Joshua Chiou +15 more
semanticscholar +1 more source