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Type 1 diabetes [PDF]

The Lancet, 2018
Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the ...
DiMeglio, Linda A., Evans-Molina, Carmella, Oram, Richard A.   +2 more
core   +10 more sources

Type 1 diabetes [PDF]

The Lancet, 2023
Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β cells. Individuals with type 1 diabetes are reliant on insulin for survival.
Mastrandrea, Lucy D, Quattrin, Teresa, Walker, Lucy SK   +2 more
core   +4 more sources

Inflammasomes and Type 1 Diabetes [PDF]

Frontiers in Immunology, 2021
Microbiota have been identified as an important modulator of susceptibility in the development of Type 1 diabetes in both animal models and humans. Collectively these studies highlight the association of the microbiota composition with genetic risk ...
James Alexander Pearson, F. Susan Wong, Li Wen   +2 more
doaj   +3 more sources

PDE12 in type 1 diabetes [PDF]

Scientific Reports, 2022
Type 1 diabetes (T1D) incidence is increased after COVID-19 infection in children under 18 years of age. Interferon-α-activated oligoadenylate synthetase and downstream RNAseL activation degrade pathogen RNA, but can also damage host RNA when RNAseL ...
Hasim Tekin, Knud Josefsen, Lars Krogvold, Knut Dahl-Jørgensen, Ivan Gerling, Flemming Pociot, Karsten Buschard   +6 more
doaj   +5 more sources

Microbiome and type 1 diabetes [PDF]

EBioMedicine, 2019
The steep increase in the incidence of type 1 diabetes (T1D), in the Western world after World War II, cannot be explained solely by genetic factors but implies that this rise must be due to crucial interactions between predisposing genes and ...
Heli Siljander, Jarno Honkanen, Mikael Knip   +2 more
doaj   +5 more sources

Puberty and type 1 diabetes

Indian Journal of Endocrinology and Metabolism, 2015
Various data on type 1 diabetes mellitus (T1DM) have showed that the incidence of T1DM peaks at puberty. However, diabetes control and complications could be adversely affected by the physiological changes of puberty.
Subhankar Chowdhury
doaj   +4 more sources

Characterization of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells

Frontiers in Endocrinology, 2023
ObjectiveEndoC-βH5 is a newly established human beta-cell model which may be superior to previous model systems. Exposure of beta cells to pro-inflammatory cytokines is widely used when studying immune-mediated beta-cell failure in type 1 diabetes.
Caroline Frørup, Rebekka Gerwig, Cecilie Amalie Søndergaard Svane, Joana Mendes Lopes de Melo, Kristine Henriksen, Tina Fløyel, Flemming Pociot, Flemming Pociot, Simranjeet Kaur, Joachim Størling, Joachim Størling   +10 more
doaj   +1 more source

Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells

Non-Coding RNA, 2022
Circular RNAs (circRNAs) have recently been implicated in impaired β-cell function in diabetes. Using microarray-based profiling of circRNAs in human EndoC-βH1 cells treated with pro-inflammatory cytokines, this study aimed to investigate the expression ...
Simranjeet Kaur, Caroline Frørup, Aashiq H. Mirza, Tina Fløyel, Reza Yarani, Maikel L. Colli, Jesper Johannesen, Joachim Størling, Decio L. Eizirik, Flemming Pociot   +9 more
doaj   +1 more source

Type 1 Diabetes

Endocrinology and Metabolism Clinics of North America
Lucier J, Mathias PM.
europepmc   +3 more sources

Type 1 Diabetes [PDF]

JAMA, 2003
Diabetes is a complex metabolic disorder diagnosed on the basis of hyperglycemia. Diagnostic criteria for the disorder are periodically revised (1). Diabetes may be classified mainly into types 1 and 2 based on the etiology and severity of insulin deficiency (1).
Cassio Lynm, Janet M. Torpy, Richard M Glass   +2 more
openaire   +6 more sources