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Type 1 Diabetes [PDF]

open access: yes, 2007
It is well known that type 1 diabetes is a chronic autoimmune disease in which the breakdown of normal tolerance to the cell allows the activation of T cell to multiple antigens. This induces a progressive destruction of cells and a state of chronic insulin deficiency.
Cosimo Giannini, Francesco Chiarelli
openaire   +2 more sources

Type 1 diabetes pathogenesis - Prevention???

open access: yesIndian Journal of Endocrinology and Metabolism, 2015
Pathogenesis of type 1 diabetes is multi-faceted, including, autoimmunity, genetics and environment. Autoimmunity directed against pancreatic islet cells results in slowly progressive selective beta-cell destruction ("Primary autoimmune insulitis ...
C S Muralidhara Krishna, S Srikanta
doaj   +1 more source

"Type 1 on Type 2" Diabetes Mellitus: Autoimmune Type 1 Diabetes Superimposed on Established Type 2 Diabetes

open access: yesInternal Medicine, 2007
To investigate clinical features and pathophysiology of a rare form of new-onset type 1 diabetes mellitus that was superimposed on established type 2 diabetes.We retrospectively analyzed 126 consecutive type 2 diabetic patients, who were admitted to the hospital 2 or more times from July 2000 to December 2005 and had been repeatedly examined for islet ...
Kenji Takahashi   +6 more
openaire   +4 more sources

Exploring Biomarker Relationships in Both Type 1 and Type 2 Diabetes Mellitus Through a Bayesian Network Analysis Approach [PDF]

open access: yesarXiv
Understanding the complex relationships of biomarkers in diabetes is pivotal for advancing treatment strategies, a pressing need in diabetes research. This study applies Bayesian network structure learning to analyze the Shanghai Type 1 and Type 2 diabetes mellitus datasets, revealing complex relationships among key diabetes-related biomarkers.
arxiv  

Gad65 is recognized by t-cells, but not by antibodies from nod-mice [PDF]

open access: yes, 1994
Since the 64kDa-protein glutamic acid decarboxylase (GAD) is one of the major autoantigens in T-cell mediated Type 1 diabetes, its relevance as a T-cell antigen needs to be clarified. After isolation of splenic T-cells from non-obese diabetic (NOD) mice,
Alzari PM   +28 more
core   +1 more source

Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy

open access: yesBioactive Materials
Inflammatory bowel disorders (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract (GIT). They pose significant treatment challenges due to their complex etiology.
George Chigozie Njoku   +5 more
doaj  

Prevalence of type 1 diabetes among children aged 0–14 in Australia 2013 [PDF]

open access: yes
Prevalence of type 1 diabetes among children aged 0–14 in Australia 2013 presents the first national picture of children aged 0–14 living with type 1 diabetes in Australia.
Karen Byng, Sarah Bullock
core  

Reconsidering your perceptions: exploring the lifeworld of a young person with type 1 diabetes [PDF]

open access: yes, 2013
Introduction Views of young people with type 1 diabetes are vital in developing quality services, yet research on their lifestyle and use of web and mobile technology to support their condition is sparse. We aimed to develop a deeper understanding of the
Hill, J., Masding, M.G., Pulman, Andy
core  

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