Decline in titers of anti-idiotypic antibodies specific to autoantibodies to GAD65 (GAD65Ab) precedes development of GAD65Ab and type 1 diabetes. [PDF]
PLoS ONE, 2013 The humoral Idiotypic Network consisting of antibodies and their anti-idiotypic antibodies (anti-Id) can be temporarily upset by antigen exposure. In the healthy immune response the original equilibrium is eventually restored through counter-regulatory ...
Helena Elding Larsson +7 more
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Young people with type 1 diabetes and their transition to adult services. [PDF]
, 2013 More than 85% of children and young people with type 1 diabetes are not achieving the recommended target of
Kime, N
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The Journal of Clinical Endocrinology & Metabolism, 2005 Type 1 diabetes is a common, multifactorial disease with strong familial clustering (genetic risk ratio [λS] ∼ 15). Approximately 40% of the familial aggregation of type 1 diabetes can be attributed to allelic variation of HLA loci in the major histocompatibility complex on chromosome 6p21 (locus-specific λS ∼ 3).
William L. Isley, Mark E. Molitch
openaire +3 more sources
BMJ Open, 2022 Objectives To investigate low-grade inflammation in type 2 diabetes and explore associations to clinical aspects as well as microvascular and macrovascular complications.Design Cross-sectional analysis.Setting The outpatient diabetes clinic at the ...
Joachim Størling +5 more
doaj +1 more source
Adolescents’ view and experiences of living with type 1 diabetes [PDF]
, 2016 This literature review aims to explore the perceptions and experiences of adolescents living with Type 1 Diabetes, and its impact on their lives. The prevalence and the number of adolescents living with this condition are rapidly increasing in western ...
Ellis, M.R.C., Jayarajah, C.
core +1 more source
Primary understanding of type 1 diabetes as an autoimmune disease
Saudi Journal for Health Sciences, 2022 Type 1 diabetes (T1D) is classified as an autoimmune disease affecting a wide range of people worldwide. Beta cells in the pancreatic islets of Langerhans in the pancreases are responsible for insulin productions, which help in the exchange of blood ...
Mohamd A Alblihed
doaj +1 more source
Failure to Preserve β-Cell Function With Mycophenolate Mofetil and Daclizumab Combined Therapy in Patients With New- Onset Type 1 Diabetes [PDF]
, 2010 OBJECTIVE This trial tested whether mycophenolate mofetil (MMF) alone or with daclizumab (DZB) could arrest the loss of insulin-producing β-cells in subjects with new-onset type 1 diabetes.
Gottlieb, Peter A. +10 more
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miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
Nature Communications, 2019 miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.
Martin G. Scherm +11 more
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The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity
Molecular Metabolism, 2019 Background: microRNAs (miRNAs) have emerged as critical contributors to immune regulation and homeostasis, and their dysregulation is involved in the aberrant differentiation and function of T cell subsets.
Martin G. Scherm +3 more
doaj +1 more source
Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials [PDF]
, 2017 OBJECTIVE: We assessed dysglycemia and a T1D Diagnostic Index60 (Index60) ≥1.00 (on the basis of fasting C-peptide, 60-min glucose, and 60-min C-peptide levels) as prediagnostic end points for type 1 diabetes among Type 1 Diabetes TrialNet Pathway to ...
Atkinson, Mark A. +14 more
core +1 more source