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Recent advances in understanding Type 1 Diabetes [version 1; referees: 2 approved]
F1000Research, 2016 Type 1 diabetes is a multifactorial disease in which genetic and environmental factors play a key role. The triggering event is still obscure, and so are many of the immune events that follow.
Gustaf Christoffersson +2 more
doaj +1 more source
Frontiers in Immunology, 2021 In human type 1 diabetes and animal models of the disease, a diverse assortment of immune cells infiltrates the pancreatic islets. CD8+ T cells are well represented within infiltrates and HLA multimer staining of pancreas sections provides clear evidence
Teresa Rodriguez-Calvo +9 more
doaj +1 more source
Type 1 diabetes and cardiovascular disease [PDF]
, 2013 The presence of cardiovascular disease (CVD) in Type 1 diabetes largely impairs life expectancy. Hyperglycemia leading to an increase in oxidative stress is considered to be the key pathophysiological factor of both micro- and macrovascular complications.
Cappuccio, Francesco +5 more
core +2 more sources
Ketoacidosis in type 2 diabetes- is it type 1 and 1/2 diabetes? [PDF]
Case Reports, 2011 A 64-year-old female with a background of type 2 diabetes became acutely unwell after being transferred from insulin to liraglutide, which is one of the new glucagon like peptide 1 analogues. On assessment in accident and emergency, she was diagnosed with diabetic ketoacidosis and pancreatits. Glutamic acid decarboxylase antibodies were positive at 45 (
Sathis Kumar +2 more
openaire +2 more sources
, 2007 This chapter provides an overview of the role of psychological stress in Type 1 diabetes. Studies relating to stress and Type 1 diabetes onset and control, as well as the evidence relating to stress management training in people with Type 1 diabetes are discussed.
Riazi, Afsane, Bradley, Clare
openaire +19 more sources
Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
Nature Communications, 2016 Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a ...
Isabelle Serr +11 more
doaj +1 more source
Decline in titers of anti-idiotypic antibodies specific to autoantibodies to GAD65 (GAD65Ab) precedes development of GAD65Ab and type 1 diabetes. [PDF]
PLoS ONE, 2013 The humoral Idiotypic Network consisting of antibodies and their anti-idiotypic antibodies (anti-Id) can be temporarily upset by antigen exposure. In the healthy immune response the original equilibrium is eventually restored through counter-regulatory ...
Helena Elding Larsson +7 more
doaj +1 more source
Primary understanding of type 1 diabetes as an autoimmune disease
Saudi Journal for Health Sciences, 2022 Type 1 diabetes (T1D) is classified as an autoimmune disease affecting a wide range of people worldwide. Beta cells in the pancreatic islets of Langerhans in the pancreases are responsible for insulin productions, which help in the exchange of blood ...
Mohamd A Alblihed
doaj +1 more source
A quantitative measure of treatment response in recent‐onset type 1 diabetes
Endocrinology, Diabetes & Metabolism, 2020 Introduction This paper develops a methodology and defines a measure that can be used to separate subjects that received an experimental therapy into those that benefitted from those that did not in recent‐onset type 1 diabetes.
Brian N. Bundy +2 more
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Does Type 1 Diabetes Affect Male Infertility: Type 1 Diabetes Exchange Registry-Based Analysis
Société Internationale d’Urologie Journal, 2021 IntroductionThe prevalence of type 1 diabetes (T1D) has been increasing over the last few decades and is commonly believed to negatively impact male fertility.
Omer A. Raheem, Marah C. Hehemann, Marc J. Rogers, Judy N. Fustok, Irl B. Hirsch, Thomas J. Walsh
doaj +1 more source