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'Join us on our journey': Exploring the experiences of children and young people with type 1 diabetes and their parents [PDF]

, 2014
This paper focuses on children and young people with type 1 diabetes and on their parents, and their experiences of diabetes care provision. Nine acute hospitals in the Yorkshire and the Humber region, UK, were recruited to participate in a qualitative ...
Department of Health, Department of Health, Diabetes Control and Complications Trial Research Group, Diabetes UK, Diamond Project Group, Epidemiology of Diabetes Interventions and Complications Research Group., Gunn, Kanavos, Kennedy, Kime, Miles, NHS Confederation, Patterson, Peyrot, Randell, The, Wood   +16 more
core   +1 more source

Diabetic nephropathy in type 1 diabetes

Minerva Medica, 2018
Diabetic nephropathy (DN) also named diabetic kidney disease (DN) is one of the leading causes of mortality in people with diabetes. The aim of this review is to update the medical literature, the theories behind its early natural history, the pathways of its pathogenesis, its diagnosis and treatment.
Papadopoulou-Marketou, N., Paschou, S.A., Marketos, N., Adamidi, S., Adamidis, S., Kanaka-Gantenbein, C.   +5 more
openaire   +3 more sources

Decline in titers of anti-idiotypic antibodies specific to autoantibodies to GAD65 (GAD65Ab) precedes development of GAD65Ab and type 1 diabetes. [PDF]

PLoS ONE, 2013
The humoral Idiotypic Network consisting of antibodies and their anti-idiotypic antibodies (anti-Id) can be temporarily upset by antigen exposure. In the healthy immune response the original equilibrium is eventually restored through counter-regulatory ...
Helena Elding Larsson, Ida Jönsson, Ake Lernmark, Sten Ivarsson, Jared R Radtke, Christiane S Hampe, Diabetes Prediction in Skåne (DiPiS), Type 1 Diabetes Trial Network   +7 more
doaj   +1 more source

Long-term glycemic variability and risk of adverse outcomes: a systematic review and meta-analysis [PDF]

, 2015
OBJECTIVE: Glycemic variability is emerging as a measure of glycemic control, which may be a reliable predictor of complications. This systematic review and meta-analysis evaluates the association between HbA1c variability and micro- and macrovascular ...
Catherine Gorst, Cavalot, Chun Shing Kwok, Evangelos Kontopantelis, Foo, Grant Heatlie, Hermann, Iain Buchan, Kontopantelis, Lin, Maciejewski, Mamas A. Mamas, Martin K. Rutter, Phyo K. Myint, Raman, Saadia Aslam, Skriver, Sperrin, Yoon Loke   +18 more
core   +1 more source

Diabetes distress and marriage in Type-1 diabetes

Indian Journal of Community Medicine, 2018
In spite of the large number of people with Type-1 diabetes mellitus (T1DM) in India, India is not a diabetes-friendly society. The society suffers from lots of myths regarding diabetes and insulin use. This review highlights challenges faced by young people living with T1DM with regards to marriage, associated diabetes distress, and suggests potential
Deepak Khandelwal, Lovely Gupta, Sanjay Kalra, Amit Vishwakarma, Priti Rishi Lal, Deep Dutta   +5 more
openaire   +3 more sources

Type 1 Diabetes at a Crossroads! [PDF]

Diabetes Care, 2015
“Be at a crossroads”: to be at a stage in your life when you have to make a very important decision (1). Type 1 diabetes at a crossroads? What does that really mean? It cannot mean that progress has not been made! Indeed, in the field of diabetes, reporting of new information is clearly outpacing our ability to incorporate new findings into clinical ...
Cefalu, William T., Tamborlane, William V., Skyler, Jay S.   +2 more
openaire   +2 more sources

Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice

Nature Communications, 2016
Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a ...
Isabelle Serr, Rainer W. Fürst, Peter Achenbach, Martin G. Scherm, Füsun Gökmen, Florian Haupt, Eva-Maria Sedlmeier, Annette Knopff, Leonard Shultz, Richard A. Willis, Anette-Gabriele Ziegler, Carolin Daniel   +11 more
doaj   +1 more source

A quantitative measure of treatment response in recent‐onset type 1 diabetes

Endocrinology, Diabetes & Metabolism, 2020
Introduction This paper develops a methodology and defines a measure that can be used to separate subjects that received an experimental therapy into those that benefitted from those that did not in recent‐onset type 1 diabetes.
Brian N. Bundy, Jeffrey P. Krischer, for the Type 1 Diabetes TrialNet Study Group   +2 more
doaj   +1 more source

Low-grade inflammation in type 2 diabetes: a cross-sectional study from a Danish diabetes outpatient clinic

BMJ Open, 2022
Objectives To investigate low-grade inflammation in type 2 diabetes and explore associations to clinical aspects as well as microvascular and macrovascular complications.Design Cross-sectional analysis.Setting The outpatient diabetes clinic at the ...
Joachim Størling, Christina Brock, Tina Okdahl, Birgitte Brock, Flemming Pociot, Anne-Marie Wegeberg   +5 more
doaj   +1 more source

Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials [PDF]

, 2017
OBJECTIVE: We assessed dysglycemia and a T1D Diagnostic Index60 (Index60) ≥1.00 (on the basis of fasting C-peptide, 60-min glucose, and 60-min C-peptide levels) as prediagnostic end points for type 1 diabetes among Type 1 Diabetes TrialNet Pathway to ...
Atkinson, Mark A., Boulware, David, Colman, Peter, Evans-Molina, Carmella, Geyer, Susan, Goland, Robin, Moran, Antoinette, Nathan, Brandon M., Russell, William, Skyler, Jay S., Sosenko, Jay M., Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups, Wentworth, John M., Wherrett, Diane, Wilson, Darrell M.   +14 more
core   +1 more source