Results 51 to 60 of about 4,565,322 (357)

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

Nature Communications, 2019
miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.
Martin G. Scherm, Isabelle Serr, Adam M. Zahm, Jonathan Schug, Saverio Bellusci, Rossella Manfredini, Victoria K. Salb, Katharina Gerlach, Benno Weigmann, Anette-Gabriele Ziegler, Klaus H. Kaestner, Carolin Daniel   +11 more
doaj   +1 more source

The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity

Molecular Metabolism, 2019
Background: microRNAs (miRNAs) have emerged as critical contributors to immune regulation and homeostasis, and their dysregulation is involved in the aberrant differentiation and function of T cell subsets.
Martin G. Scherm, Isabelle Serr, Klaus H. Kaestner, Carolin Daniel   +3 more
doaj   +1 more source

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes.

New England Journal of Medicine, 2019
BACKGROUND Type 1 diabetes is a chronic autoimmune disease that leads to destruction of insulin-producing beta cells and dependence on exogenous insulin for survival.
Herold Kc, Bundy Bn, Long Sa, Bluestone Ja, DiMeglio La, Dufort Mj, Gitelman Se, Gottlieb Pa, Krischer Jp, Linsley Ps, Marks Jb, Moore W, Moran A, Rodriguez H, Russell We, Schatz D, Skyler Js, Tsalikian E, Wherrett Dk, Ziegler Ag, Greenbaum Cj   +20 more
semanticscholar   +1 more source

Inhibition of pyrimidine de novo synthesis fosters Treg cells and reduces diabetes development in models of Type 1 Diabetes

Molecular Metabolism
Objective: In autoimmune Type 1 Diabetes (T1D), aberrant immune activation promotes regulatory T cell (Treg) impairments thereby boosting progression of islet autoimmunity.
Hannah Hipp, Camilla Tondello, Hanna Gmehling, Lena K. Scholz, Antigoni Stavridou, Maike Becker, Anne-Marie Bührer, Edith Hintermann, Sandra M. Dirschl, Till M. Johannsmann, Martin G. Scherm, Hella Kohlhof, Isabelle Serr, Urs Christen, Carolin Daniel   +14 more
doaj   +1 more source

Collagenase Isoforms for Pancreas Digestion

Cell Transplantation, 2009
The available information concerning the characteristics and composition of collagenase batches, which are effective in the digestion of human pancreas for islet transplants, is scarce and incomplete.
Federico Bertuzzi, Silvia Cainarca, Simona Marzorati, Angela Bachi, Barbara Antonioli, Rita Nano, Roberto Verzaro, Camillo Ricordi   +7 more
doaj   +1 more source

Trends in Incidence of Type 1 and Type 2 Diabetes Among Youths — Selected Counties and Indian Reservations, United States, 2002–2015

MMWR. Morbidity and mortality weekly report, 2020
Diabetes is one of the most common chronic diseases among persons aged
J. Divers, E. Mayer‐Davis, J. Lawrence, S. Isom, D. Dabelea, L. Dolan, G. Imperatore, S. Marcovina, D. Pettitt, C. Pihoker, R. Hamman, S. Saydah, L. Wagenknecht   +12 more
semanticscholar   +1 more source

Etiology of Type 1 Diabetes [PDF]

Immunity, 2010
Recent genetic mapping and gene-phenotype studies have revealed the genetic architecture of type 1 diabetes. At least ten genes so far can be singled out as strong causal candidates. The known functions of these genes indicate the primary etiological pathways of this disease, including HLA class II and I molecules binding to preproinsulin peptides and ...
openaire   +3 more sources

Prediction of Type 1 Diabetes [PDF]

Diabetes, 2013
Type 1 diabetes (T1D) is a chronic autoimmune disorder in which the destruction of the insulin-producing cells and resulting clinical symptoms are preceded by the appearance of a number of islet-cell specific autoantibodies. Linkage (1) and association analyses have demonstrated that type 1 diabetes has a very strong genetic component, with specific ...
Ana M. Valdes, Henry A. Erlich, Janelle A. Noble   +2 more
openaire   +2 more sources

Pancreatic Tissue Transplanted in TheraCyte Encapsulation Devices Is Protected and Prevents Hyperglycemia in a Mouse Model of Immune-Mediated Diabetes

Cell Transplantation, 2016
Type 1 diabetes (T1D) is characterized by destruction of glucose-responsive insulin-producing pancreatic β-cells and exhibits immune infiltration of pancreatic islets, where CD8 lymphocytes are most prominent.
Tobias Boettler, Darius Schneider, Yang Cheng, Kuniko Kadoya, Eugene P. Brandon, Laura Martinson, Matthias Von Herrath   +6 more
doaj   +1 more source

Did the COVID-19 Lockdown Affect the Incidence of Pediatric Type 1 Diabetes in Germany?

Diabetes Care, 2020
Psychological stress is a known general health risk potentially increasing the risk of type 1 diabetes. Consistent with this hypothesis, there were reports of a higher incidence of type 1 diabetes after other stressful catastrophic events, e.g., the ...
S. Tittel, J. Rosenbauer, C. Kamrath, Julian Ziegler, F. Reschke, J. Hammersen, K. Mönkemöller, Angeliki Pappa, T. Kapellen, R. Holl   +9 more
semanticscholar   +1 more source