Results 51 to 60 of about 2,770,969 (263)

Sample size requirements for studies of treatment effects on beta-cell function in newly diagnosed type 1 diabetes. [PDF]

PLoS ONE, 2011
Preservation of β-cell function as measured by stimulated C-peptide has recently been accepted as a therapeutic target for subjects with newly diagnosed type 1 diabetes.
John M Lachin, Paula L McGee, Carla J Greenbaum, Jerry Palmer, Mark D Pescovitz, Peter Gottlieb, Jay Skyler, Type 1 Diabetes Trial Network   +7 more
doaj   +1 more source

Study protocol of Diabetes LEAP: a longitudinal study examining emotional problems in adolescents with type 1 diabetes and their parents/caregivers

BMC Pediatrics, 2019
Background Type 1 diabetes (T1D) is a chronic metabolic condition requiring intensive daily self-care to avoid both high and low blood glucose levels.
Giesje Nefs, Linh Nguyen, Per Winterdijk, Esther Hartman, Theo Sas, Roos Nuboer, Ineke De Kruijff, Willie Bakker-van Waarde, Henk-Jan Aanstoot, Frans Pouwer   +9 more
doaj   +1 more source

Hypoglycemia in Type 1 Diabetes [PDF]

Diabetes, 2010
In subjects with type 1 diabetes, autoimmune destruction of pancreatic β-cells leads eventually to an absolute requirement for insulin replacement therapy. Insulin delivered exogenously is not subject to normal physiological feedback regulation, so it may induce hypoglycemia even in the presence of an intact counterregulatory response.
McCrimmon, Rory J., Sherwin, Robert S.
openaire   +3 more sources

Etiology of Type 1 Diabetes [PDF]

Immunity, 2010
Recent genetic mapping and gene-phenotype studies have revealed the genetic architecture of type 1 diabetes. At least ten genes so far can be singled out as strong causal candidates. The known functions of these genes indicate the primary etiological pathways of this disease, including HLA class II and I molecules binding to preproinsulin peptides and ...
openaire   +3 more sources

Prediction of Type 1 Diabetes [PDF]

Diabetes, 2013
Type 1 diabetes (T1D) is a chronic autoimmune disorder in which the destruction of the insulin-producing cells and resulting clinical symptoms are preceded by the appearance of a number of islet-cell specific autoantibodies. Linkage (1) and association analyses have demonstrated that type 1 diabetes has a very strong genetic component, with specific ...
Ana M. Valdes, Henry A. Erlich, Janelle A. Noble   +2 more
openaire   +2 more sources

Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials [PDF]

, 2017
OBJECTIVE: We assessed dysglycemia and a T1D Diagnostic Index60 (Index60) ≥1.00 (on the basis of fasting C-peptide, 60-min glucose, and 60-min C-peptide levels) as prediagnostic end points for type 1 diabetes among Type 1 Diabetes TrialNet Pathway to ...
Atkinson, Mark A., Boulware, David, Colman, Peter, Evans-Molina, Carmella, Geyer, Susan, Goland, Robin, Moran, Antoinette, Nathan, Brandon M., Russell, William, Skyler, Jay S., Sosenko, Jay M., Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups, Wentworth, John M., Wherrett, Diane, Wilson, Darrell M.   +14 more
core   +1 more source

The TCF7L2locus and type 1 diabetes [PDF]

BMC Medical Genetics, 2007
TCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion.
Hui-Qi Qu, Constantin Polychronakos
openaire   +4 more sources

Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments

Nature Communications
The hypothalamus in the central nervous system (CNS) has important functions in controlling systemic metabolism. A calorie-rich diet triggers CNS immune activation, impairing metabolic control and promoting obesity and Type 2 Diabetes (T2D), but the ...
Maike Becker, Stefanie Kälin, Anne H. Neubig, Michael Lauber, Daria Opaleva, Hannah Hipp, Victoria K. Salb, Verena B. Ott, Beata Legutko, Roland E. Kälin, Markus Hippich, Martin G. Scherm, Lucas F. R. Nascimento, Isabelle Serr, Fabian Hosp, Alexei Nikolaev, Alma Mohebiany, Martin Krueger, Bianca Flachmeyer, Michael W. Pfaffl, Bettina Haase, Chun-Xia Yi, Sarah Dietzen, Tobias Bopp, Stephen C. Woods, Ari Waisman, Benno Weigmann, Matthias Mann, Matthias H. Tschöp, Carolin Daniel   +29 more
doaj   +1 more source

Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each other

Molecular Metabolism, 2022
Background: The highly complex pathogenesis of Type 1 Diabetes is driven by several immune cell types with both effector and regulatory characteristics, which ultimately ends in the destruction of the insulin-producing beta cells.
Martin G. Scherm, Rebecca C. Wyatt, Isabelle Serr, David Anz, Sarah J. Richardson, Carolin Daniel   +5 more
doaj  

An Ensemble Learning Approach for Exercise Detection in Type 1 Diabetes Patients [PDF]

arXiv, 2023
Type 1 diabetes is a serious disease in which individuals are unable to regulate their blood glucose levels, leading to various medical complications. Artificial pancreas (AP) systems have been developed as a solution for type 1 diabetic patients to mimic the behavior of the pancreas and regulate blood glucose levels.
arxiv