Results 71 to 80 of about 2,183,210 (336)

Long-term glycemic variability and risk of adverse outcomes: a systematic review and meta-analysis [PDF]

open access: yes, 2015
OBJECTIVE: Glycemic variability is emerging as a measure of glycemic control, which may be a reliable predictor of complications. This systematic review and meta-analysis evaluates the association between HbA1c variability and micro- and macrovascular ...
Catherine Gorst   +18 more
core   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Prevalence of microvascular complications in adolescents and adults with type 1 diabetes: A descriptive study from India

open access: yesJournal of Diabetology, 2022
Objective: The aim of this work was to study the prevalence of microvascular complications in type 1 diabetes among the young adolescents and adults of Ahmedabad, Gujarat. Materials and Methods: This descriptive study was carried out at the diabetes care
Mahira Saiyed   +4 more
doaj   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

'Join Us On Our Journey': developing a new model of care for children and young people with type 1 diabetes Final report for NHS Diabetes [PDF]

open access: yes, 2012
The aims of this research were to develop a model of care that will deliver the aspirations of the policy document, ‘Making Every Young Person with Diabetes Matter’ and improve the care provision for children and young people with Type 1 diabetes in ...
Carlin, E, Kime, NH
core  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

The emerging role of targeting cancer metabolism for cancer therapy

open access: yesTumor Biology, 2020
Glucose, as the main consuming nutrient of the body, faces different destinies in cancer cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce different glucose-derived metabolites and thus affect cells’ bioenergetics ...
Pegah Farhadi   +3 more
doaj   +1 more source

Type 1 Diabetes and Sleep [PDF]

open access: yesDiabetes Spectrum, 2016
IN BRIEF In people with type 1 diabetes, sleep may be disrupted as a result of both behavioral and physiological aspects of diabetes and its management. This sleep disruption may negatively affect disease progression and development of complications. This review highlights key research findings regarding sleep in people with type 1 diabetes.
openaire   +2 more sources

Adolescents’ view and experiences of living with type 1 diabetes [PDF]

open access: yes, 2016
This literature review aims to explore the perceptions and experiences of adolescents living with Type 1 Diabetes, and its impact on their lives. The prevalence and the number of adolescents living with this condition are rapidly increasing in western ...
Ellis, M.R.C., Jayarajah, C.
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

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