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Cohort profile: the ‘Biomarkers of heterogeneity in type 1 diabetes’ study—a national prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes in the Netherlands

BMJ Open
Purpose The ‘Biomarkers of heterogeneity in type 1 diabetes’ study cohort was set up to identify genetic, physiological and psychosocial factors explaining the observed heterogeneity in disease progression and the development of complications in people ...
, Erwin Birnie, Giesje Nefs, Bruce H R Wolffenbuttel, Melanie M van der Klauw, Peter R van Dijk, Klaas Hoogenberg, Henk J Veeze, Henk-Jan Aanstoot, Bruce HR Wolffenbuttel, Charlotte E Vollenbrock, Pim Dekker, Lianne S M Boesten, Martine M C de Vries-Velraeds, Adriaan Kooy, Dick Mul, Sanjoy Dutta, Rita D M Varkevisser, Michael P Brugts, Petronella H L M Duijvestijn, Christine Fransman, Rob K Gonera, Esther Latres, Sandra Loves, Theo Sas, Marleen J Vosjan-Noeverman, Rita DM Varkevisser, Lianne SM Boesten, Peter R van Dijk, Petronella HLM Duijvestijn, Martine MC de Vries-Velraeds, Melanie M van der Klauw   +31 more
doaj   +1 more source

Can prevent type 1 diabetes?

Revista de la Sociedad Argentina de Diabetes, 2022
Type 1 diabetes (T1D) is caused by the autoimmune destruction of β cells of the pancreas, driven by CD4+ and CD8+ T lymphocytes. The humoral branch represented by B lymphocytes is responsible for producing autoantibodies (AAs) against specific antigens ...
Gustavo Frechtel
doaj   +1 more source

Behavioral Factors Influencing Health Outcomes in Youth with Type 1 Diabetes [PDF]

, 2012
The Pediatric Self-Management Model provides an overview of how behavioral factors influence children’s chronic medical illnesses. This general framework is used to organize the present review of how self-management behaviors, contextual factors, and ...
Kaugars, Astrida S., Kichler, Jessica C., Moss, Ashley   +2 more
core   +1 more source

Relationship between plasma sialic acid and fibinogen concentration and incident micro-and macrovascular complications in type 1 diabetes [PDF]

, 2008
AIMS/HYPOTHESIS: Type 1 diabetes is associated with an increased risk of vascular complications. This increased risk could be explained by sialic acid and/or fibrinogen.
CHATURVEDI N, FULLER JH, MICCOLI, ROBERTO, On behalf of EURODIAB PCS STUDY GROUP, PICKUP JC, SOEDAMAH MUTHU SS   +5 more
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Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Phase angle and body composition in long-term type 1 diabetes in adults: a comparative study in a Brazilian public reference outpatient clinic

Diabetology & Metabolic Syndrome
Introduction Type 1 Diabetes Mellitus (DM1) affects a small percentage of the population. Nevertheless, its prevalence is currently growing with alarming data on uncontrolled cases.
Natália Fenner-Pena, Virgínia Capistrano Fajardo, Lívia Froes, Paulo Augusto Miranda Carvalho, Fábio Vasconcellos Comim, Viviane Sahade, Márcio Weissheimer Lauria, Henrique Oswaldo da Gama Torres   +7 more
doaj   +1 more source

The importance of diet and exercise in preventing type 2 diabetes [PDF]

, 2014
Diabetes is reaching epidemic proportions globally with estimates of 374 million people worldwide (WHO 2014 ) and impacts on the people with the condition, their families and on health service resources.
McDowell, Joan
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Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes [PDF]

, 2019
OBJECTIVE: Abnormally elevated proinsulin secretion has been reported in type 2 and early type 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing type 1 diabetes and low or absent C-peptide secretory
Arvan, Peter, Bahnson, Henry T., Blum, Janice, Considine, Robert V., Davis, Asa K., DiMeglio, Linda A., Evans-Molina, Carmella, Greenbaum, Carla J., Haataja, Leena, Marcovina, Santica, Mastracci, Teresa L., Mirmira, Raghavendra G., Morris, Margaret A., Nadler, Jerry, Nyalwidhe, Julius, Qian, Wei-Jun, Schmidt, C. Max, Sims, Emily K., Speake, Cate, Swensen, Adam C., T1D Exchange Residual C-peptide Study Group, Yi, Lian, Yip-Schneider, Michele   +22 more
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Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Reconsidering your perceptions: exploring the lifeworld of a young person with type 1 diabetes [PDF]

, 2013
Introduction Views of young people with type 1 diabetes are vital in developing quality services, yet research on their lifestyle and use of web and mobile technology to support their condition is sparse. We aimed to develop a deeper understanding of the
Hill, J., Masding, M.G., Pulman, Andy
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