Results 71 to 80 of about 2,420,770 (348)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Phase angle and body composition in long-term type 1 diabetes in adults: a comparative study in a Brazilian public reference outpatient clinic

Diabetology & Metabolic Syndrome
Introduction Type 1 Diabetes Mellitus (DM1) affects a small percentage of the population. Nevertheless, its prevalence is currently growing with alarming data on uncontrolled cases.
Natália Fenner-Pena, Virgínia Capistrano Fajardo, Lívia Froes, Paulo Augusto Miranda Carvalho, Fábio Vasconcellos Comim, Viviane Sahade, Márcio Weissheimer Lauria, Henrique Oswaldo da Gama Torres   +7 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

The importance of diet and exercise in preventing type 2 diabetes [PDF]

, 2014
Diabetes is reaching epidemic proportions globally with estimates of 374 million people worldwide (WHO 2014 ) and impacts on the people with the condition, their families and on health service resources.
McDowell, Joan
core  

Children and young people’s experiences and perceptions of self-management of type 1 diabetes: A qualitative meta-synthesis [PDF]

, 2019
The aim of this review was to conduct a meta-synthesis of the experiences and perceptions of self-management of type 1 diabetes of children and young people living with type 1 diabetes (CYPDs).
Gallagher, Pamela, Glacken, Michele, Lambert, Veronica, Murphy, Nuala, Rawdon, Caroline, Swallow, Veronica, Tuohy, Ella   +6 more
core   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Reconsidering your perceptions: exploring the lifeworld of a young person with type 1 diabetes [PDF]

, 2013
Introduction Views of young people with type 1 diabetes are vital in developing quality services, yet research on their lifestyle and use of web and mobile technology to support their condition is sparse. We aimed to develop a deeper understanding of the
Hill, J., Masding, M.G., Pulman, Andy
core  

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes [PDF]

, 2019
OBJECTIVE: Abnormally elevated proinsulin secretion has been reported in type 2 and early type 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing type 1 diabetes and low or absent C-peptide secretory
Arvan, Peter, Bahnson, Henry T., Blum, Janice, Considine, Robert V., Davis, Asa K., DiMeglio, Linda A., Evans-Molina, Carmella, Greenbaum, Carla J., Haataja, Leena, Marcovina, Santica, Mastracci, Teresa L., Mirmira, Raghavendra G., Morris, Margaret A., Nadler, Jerry, Nyalwidhe, Julius, Qian, Wei-Jun, Schmidt, C. Max, Sims, Emily K., Speake, Cate, Swensen, Adam C., T1D Exchange Residual C-peptide Study Group, Yi, Lian, Yip-Schneider, Michele   +22 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Patient and provider acceptance of telecoaching in type 2 diabetes : a mixed-method study embedded in a randomised clinical trial [PDF]

, 2016
Background: Despite advances in diagnosis and treatment of type 2 diabetes, suboptimal metabolic control persists. Patient education in diabetes has been proved to enhance self-efficacy and guideline-driven treatment, however many people with type 2 ...
Aertgeerts, Bert, Annemans, Lieven, Buysse, Heidi, Goderis, Geert, Nobels, Frank, Odnoletkova, Irina, Ramaekers, Dirk   +6 more
core   +3 more sources