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The Discovery of Type 1 Diabetes [PDF]
Diabetes, 2001 The etiological heterogeneity of idiopathic diabetes has been recognized for 25 years, and subdivision into type 1 and type 2 diabetes is fundamental to the way we think about the disease. Review of the literature suggests that the concept of type 1 diabetes as an immunemediated disease emerged rapidly over the period from 1974 to 1976 and showed many ...
openaire +3 more sources
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Rising incidence of childhood type 1 diabetes in Montenegro [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2016 Introduction. The incidence rate of childhood type1 diabetes continues to rise across Europe by an average of approximately 3-4% per annum. Objective.
Samardžić Mira +4 more
doaj +1 more source
Type 1 Diabetes and Hypoglycemia [PDF]
Diabetes Care, 2009 This is the first of a series of articles based on presentations at the American Diabetes Association Scientific Sessions held 6–10 June 2008 in San Francisco, California. Matthias von Herrath (La Jolla, CA) received the American Diabetes Association (ADA) 2008 Outstanding Scientific Achievement Award for his research on approaches to β-cell–specific ...
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The development of an innovative mobile phone app for type 1 diabetes alcohol education [PDF]
, 2013 Introduction Social media is being increasingly used to try and engage young people with their healthcare issues. However, most mobile diabetes applications (Apps) do not include personalised patient education, a key facet of diabetes self-management. We
Hill, J., Masding, M.G., Pulman, Andy
core
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Facilitators and barriers of adaptation to diabetes: experiences of Iranian patients [PDF]
, 2014 Background: Diabetes mellitus is one of the most challenging and burdensome chronic diseases of the 21st century and More than 1% of the Iranian urban population older than 20 years develops Type 2 diabetes each year.
Arshadi Bostanabad, M. +4 more
core +2 more sources
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Failure to Preserve β-Cell Function With Mycophenolate Mofetil and Daclizumab Combined Therapy in Patients With New- Onset Type 1 Diabetes [PDF]
, 2010 OBJECTIVE This trial tested whether mycophenolate mofetil (MMF) alone or with daclizumab (DZB) could arrest the loss of insulin-producing β-cells in subjects with new-onset type 1 diabetes.
Gottlieb, Peter A. +10 more
core +2 more sources
FEBS Open Bio, Volume 15, Issue 7, Page 1124-1143, July 2025.We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang +9 more
wiley +1 more source