Results 101 to 110 of about 5,397,691 (379)
Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.
New England Journal of Medicine, 2013 BACKGROUND The cardiovascular safety and efficacy of many current antihyperglycemic agents, including saxagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor, are unclear.
B. Scirica +17 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Integration of disease-specific single nucleotide polymorphisms, expression quantitative trait loci and coexpression networks reveal novel candidate genes for type 2 diabetes. [PDF]
, 2012 Aims/hypothesisWhile genome-wide association studies (GWASs) have been successful in identifying novel variants associated with various diseases, it has been much more difficult to determine the biological mechanisms underlying these associations ...
Butte, AJ +6 more
core +2 more sources
Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes.
New England Journal of Medicine, 2003 BACKGROUND Cardiovascular morbidity is a major burden in patients with type 2 diabetes. In the Steno-2 Study, we compared the effect of a targeted, intensified, multifactorial intervention with that of conventional treatment on modifiable risk factors ...
P. Gaede +5 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang +9 more
wiley +1 more source
HYPERTENSION AND DIABETES MELLITUS TYPE 2
Рациональная фармакотерапия в кардиологии, 2018 Aim. To study the effect of long-term combined antihypertensive therapy with lisinopril plus amlodipine on the parameters of central aortic pressure (CAD) and visceral obesity in patients with arterial hypertension (HT) combined with type 2 diabetes ...
M. E. Statsenko, M. V. Derevyanchenko
doaj +1 more source
Assessing the effectiveness of a clinic-based diabetes management program in a community setting [PDF]
, 2013 Diabetes in the United States occurs in approximately 8% of adults.[i] Diabetes, if not treated, can lead to many health problems such as blindness or loss of physical functioning, sometimes leading to amputation. However, Type 2 diabetes can be cured
Lupone, Justin
core +1 more source
The prevention of type 2 diabetes [PDF]
Nature Clinical Practice Endocrinology & Metabolism, 2008 Type 2 diabetes mellitus (T2DM) affects more than 7% of adults in the US and leads to substantial personal and economic burden. In prediabetic states insulin secretion and action--potential targets of preventive interventions--are impaired. In trials lifestyle modification (i.e. weight loss and exercise) has proven effective in preventing incident T2DM
Jill P. Crandall +8 more
openaire +3 more sources
Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis
FEBS Open Bio, EarlyView.Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu +6 more
wiley +1 more source