Results 71 to 80 of about 5,397,691 (379)

Glucose control and vascular complications in veterans with type 2 diabetes.

New England Journal of Medicine, 2009
BACKGROUND The effects of intensive glucose control on cardiovascular events in patients with long-standing type 2 diabetes mellitus remain uncertain.
W. Duckworth, C. Abraira, Thomas E. Moritz, D. Reda, N. Emanuele, P. Reaven, F. Zieve, J. Marks, S. Davis, R. Hayward, S. Warren, S. Goldman, M. Mccarren, Mary Ellen Vitek, W. Henderson, Grant D. Huang   +15 more
semanticscholar   +1 more source

Deconstructing Type 2 Diabetes [PDF]

Cell, 1999
There is a natural temptation to extrapolate insights from these animal models to explain the pathophysiology of human diabetes. In some cases, the animal model closely resembles the human disease, as is the case with glucokinase knockout mice and MODY2.
openaire   +3 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes [PDF]

, 2019
OBJECTIVE: Abnormally elevated proinsulin secretion has been reported in type 2 and early type 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing type 1 diabetes and low or absent C-peptide secretory
Arvan, Peter, Bahnson, Henry T., Blum, Janice, Considine, Robert V., Davis, Asa K., DiMeglio, Linda A., Evans-Molina, Carmella, Greenbaum, Carla J., Haataja, Leena, Marcovina, Santica, Mastracci, Teresa L., Mirmira, Raghavendra G., Morris, Margaret A., Nadler, Jerry, Nyalwidhe, Julius, Qian, Wei-Jun, Schmidt, C. Max, Sims, Emily K., Speake, Cate, Swensen, Adam C., T1D Exchange Residual C-peptide Study Group, Yi, Lian, Yip-Schneider, Michele   +22 more
core   +1 more source

Epidemiology of Type 2 Diabetes – Global Burden of Disease and Forecasted Trends

Journal of Epidemiology and Global Health, 2019
The rising burden of type 2 diabetes is a major concern in healthcare worldwide. This research aimed to analyze the global epidemiology of type 2 diabetes.
Moien A. B. Khan, M. J. Hashim, J. King, R. Govender, H. Mustafa, Juma Al Kaabi   +5 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Smoking and Type 2 Diabetes Mellitus [PDF]

Diabetes & Metabolism Journal, 2012
Cigarette smoking is a well-known risk factor in many diseases, including various kinds of cancer and cardiovascular disease. Many studies have also reported the unfavorable effects of smoking for diabetes mellitus.
Sang Ah Chang
doaj   +1 more source

Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy.

New England Journal of Medicine, 2001
BACKGROUND Diabetic nephropathy is the leading cause of end-stage renal disease. Interruption of the renin-angiotensin system slows the progression of renal disease in patients with type 1 diabetes, but similar data are not available for patients with ...
B. Brenner, M. Cooper, D. Zeeuw, W. Keane, W. Mitch, H. Parving, G. Remuzzi, S. Snapinn, Zhonxin Zhang, S. Shahinfar   +9 more
semanticscholar   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

MANAGEMENT OF TYPE 2 DIABETES

Health Problems of Civilization
Type 2 diabetes mellitus (T2DM) is the more common form of diabetes, characterized by insulin resistance and reduced insulin secretion; this occurs during the progression of T2DM, and high blood glucose levels.
Maitham Abdallah Albajy, Dan Florin Mihailescu   +1 more
doaj   +1 more source