Results 81 to 90 of about 5,664,310 (354)

Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes.

New England Journal of Medicine, 2020
BACKGROUND The cardiovascular effects of ertugliflozin, an inhibitor of sodium-glucose cotransporter 2, have not been established. METHODS In a multicenter, double-blind trial, we randomly assigned patients with type 2 diabetes and atherosclerotic ...
C. Cannon, R. Pratley, S. Dagogo-Jack, J. Mancuso, S. Huyck, Urszula Masiukiewicz, B. Charbonnel, R. Frederich, Silvina Gallo, F. Cosentino, W. Shih, I. Gantz, S. Terra, D. Cherney, Darren K Mcguire   +14 more
semanticscholar   +1 more source

Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study. [PDF]

, 2013
ObjectiveWe aimed to identify factors that are independently associated with the metabolic clearance rate of insulin (MCRI) and to examine the association of MCRI with incident type 2 diabetes in nondiabetic Hispanics and African Americans.Research ...
Anderson, Andrea M, Bergman, Richard N, Goodarzi, Mark O, Haffner, Steven M, Hanley, Anthony J, Lee, C Christine, Lorenzo, Carlos, Norris, Jill M, Rotter, Jerome I, Stefanovski, Darko, Wagenknecht, Lynne E   +10 more
core   +2 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Arrhythmias in type 2 diabetes mellitus

Indian Journal of Endocrinology and Metabolism, 2017
Chronic hyperglycaemia of Type 2 diabetes mellitus causes long term damage to heart resulting in coronary artery disease (CAD), myocardial infarction (MI), congestive heart failure (CHF), and sudden death from arrhythmias.
Gaurav Agarwal, Satish Kumar Singh
doaj   +1 more source

Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.

New England Journal of Medicine, 2013
BACKGROUND The cardiovascular safety and efficacy of many current antihyperglycemic agents, including saxagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor, are unclear.
B. Scirica, Deepak L. Bhatt, E. Braunwald, P. Steg, J. Davidson, B. Hirshberg, P. Ohman, R. Frederich, S. Wiviott, Elaine B. Hoffman, M. Cavender, J. Udell, N. Desai, Ofri Mosenzon, Darren K Mcguire, K. Ray, Lawrence A Leiter, I. Raz   +17 more
semanticscholar   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Bromocriptine in type 2 diabetes mellitus

Indian Journal of Endocrinology and Metabolism, 2011
Bromocriptine mesylate quick-release was approved by the Food and Drug Administration (FDA) in May 2009, for the treatment of type 2 diabetes. Bromocriptine is thought to act on the circadian neuronal activities in the hypothalamus, to reset an ...
C Shivaprasad, Sanjay Kalra
doaj   +1 more source

Animal Models of GWAS-Identified Type 2 Diabetes Genes [PDF]

, 2013
More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D).
Bellomo, EA, French, PM, McGinty, JA, Rutter, GA, Xavier, GDS   +4 more
core   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Sleep disorders in type 2 diabetes

Indian Journal of Endocrinology and Metabolism, 2017
Type 2 diabetes mellitus (T2DM) has shown to be associated with higher incidence of sleep disorders, which may be due to disease itself or because of secondary complications or associated comorbidities associated with diabetes. On the other hand, shorter
Deepak Khandelwal, Deep Dutta, Sachin Chittawar, Sanjay Kalra   +3 more
doaj   +1 more source