Biomarkers of type 2 and non-type 2 inflammation in asthma exacerbations [PDF]
Central European Journal of ImmunologyIn adult-onset asthma, two major endotypes have been proposed: T2 with eosinophilia and non-T2 characterised by neutrophils and interleukin (IL)-17. The objective of the study was to examine the endotype marker profile in patients with severe asthma who were hospitalized for exacerbations, with a focus on differentiating between viral and non-viral ...
Kosar M. Ali +6 more
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Pruritus as a Distinctive Feature of Type 2 Inflammation [PDF]
Vaccines, 2021 Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic. Pruritus might have a tremendous impact on patients’ quality of life and strongly interfere with sleep, social, and work activities.
Simone Garcovich +5 more
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Beyond CCR7: dendritic cell migration in type 2 inflammation [PDF]
Frontiers in ImmunologyConventional dendritic cells (cDCs) are crucial antigen-presenting cells that initiate and regulate T cell responses, thereby shaping immunity against pathogens, innocuous antigens, tumors, and self-antigens. The migration of cDCs from peripheral tissues
Audrey Meloun +2 more
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Multidisciplinary management of type 2 inflammation diseases using a screening tool [PDF]
Frontiers in AllergyDysregulation of type 2 (T2) immune response leads to an aberrant inflammatory reaction that constitutes the pathophysiological basis of diseases involving various organs.
Oscar Palomares +4 more
doaj +2 more sources
Stapokibart (CM310) targets IL-4Rα for the treatment of type 2 inflammation [PDF]
iScienceSummary: Stapokibart (CM310) is a humanized IL-4Rα monoclonal antibody currently undergoing phase 3 trials for type 2 inflammatory diseases. In contrast to dupilumab, which bound exclusively to human IL-4Rα, stapokibart demonstrated cross-species ...
Wei Liu +11 more
doaj +2 more sources
Impaired tryptophan metabolism by type 2 inflammation in epithelium worsening asthma [PDF]
iScienceSummary: Previous researches indicate that tryptophan metabolism is critical to allergic inflammation and that indoleamine 2,3-dioxygenase 1 (IDO1), as a key enzyme, is known for its immunosuppressive properties.
Yushan Miao +8 more
doaj +2 more sources
Correlation between bullous pemphigoid and type 2 inflammation
Pifu-xingbing zhenliaoxue zazhi, 2022 Bullous pemphigoid (BP) is one of the common autoimmune blister diseases that mainly affects the elderly. Most bullous pemphigoid patients have obvious symptom of pruritus, accompanied by elevated levels of serum total IgE, peripheral blood eosinophils ...
Yao ZHOU +6 more
doaj +1 more source
Type 2 inflammation in asthma and other airway diseases
ERJ Open Research, 2022 Chronic inflammatory airway diseases, including asthma, chronic rhinosinusitis, eosinophilic COPD and allergic rhinitis are a global health concern.
Jorge Maspero +11 more
doaj +1 more source
Vascular miR‐181b controls tissue factor‐dependent thrombogenicity and inflammation in type 2 diabetes [PDF]
, 2020 BACKGROUND: Diabetes mellitus is characterized by chronic vascular inflammation leading to pathological expression of the thrombogenic full length (fl) tissue factor (TF) and its isoform alternatively-spliced (as) TF. Blood-borne TF promotes factor (
Chakraborty, Aritra +14 more
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Type 2 inflammatory diseases in atopic dermatitis: A short review
Indian Journal of Paediatric Dermatology, 2022 Type 2 inflammatory diseases are characterized by the dysregulation of the T helper (Th) 2 pathway, the prototype being atopic dermatitis (AD). The common inflammatory pathways, genetic risk factors, epidermal barrier dysfunction, parental atopy, and ...
Ankita Choudhary +3 more
doaj +1 more source