Examining the Role of Type 2 Inflammation in Eosinophilic Esophagitis
Gastro Hep Advances, 2022 Eosinophilic esophagitis (EoE) is a chronic type 2 inflammatory disease characterized by an eosinophilic inflammatory infiltrate in the esophagus, leading to remodeling, stricture formation, and fibrosis.
Mirna Chehade +11 more
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Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. [PDF]
, 2016 Group 2 innate lymphoid cells (ILC2s) and type 2 helper T cells (Th2 cells) are the primary source of interleukin 5 (IL-5) and IL-13 during type 2 (allergic) inflammation in the lung.
Austen, K Frank +5 more
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The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities. [PDF]
, 2020 Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2 diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue and liver inflammation have been particularly well studied; however ...
Fu, Wenxian +3 more
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High-fat diet and palmitic acid amplify airway type 2 inflammation
Frontiers in Allergy, 2023 IntroductionMetabolic dysfunction such as elevated levels of saturated fatty acids (SFA) may play a role in obese asthma, but its contribution to airway inflammation remains unclear.
Kris Genelyn Dimasuay +5 more
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Essential role for proteinase-activated receptor-2 in arthritis [PDF]
, 2003 Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in mediating chronic inflammation. Using an adjuvant monoarthritis model of chronic inflammation, joint
Andrew J.H. Smith +19 more
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Islet inflammation in type 2 diabetes and physiology [PDF]
Journal of Clinical Investigation, 2017 The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell dysfunction has further highlighted the significance of inflammation in metabolic diseases. The number of intra-islet macrophages is increased in T2D, and these cells are the main source of proinflammatory cytokines within islets. Multiple human studies of T2D have
Kosei, Eguchi, Ryozo, Nagai
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Some mechanisms of inflammation development in type 2 diabetes mellitus
Сахарный диабет, 2021 Inflammation plays a key role in the development and progression of type 2 diabetes (T2DM), a disease characterized by peripheral insulin resistance and systemic glucolipotoxicity.
L. A. Bochkareva +4 more
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MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. [PDF]
, 2017 MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Type 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation.
Ansel, K Mark +7 more
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Islet inflammation in type 2 diabetes [PDF]
Diabetologia, 2016 This is a commentary on how inflammation may affect human islet beta cell function and survival in type 2 diabetes. Morphological and/or molecular evidence of inflammation is discussed in relation to different situations, and diagnostic as well as therapeutic implications are outlined.
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Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study. [PDF]
, 2018 There is a widely acknowledged association between insulin resistance and obesity/type 2 diabetes (T2DM), and insulin sensitizing treatments have proved effective in preventing diabetes and inducing weight loss.
Addessi, E +11 more
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