Contributions of innate type 2 inflammation to adipose function
Journal of Lipid Research, 2019 A critical contributor to the health consequences of the obesity epidemic is dysregulated adipose tissue (AT) homeostasis. While white, brown, and beige AT function is altered in obesity-related disease, white AT is marked by progressive inflammation and
W. Reid Bolus, Alyssa H. Hasty
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Notch Signaling Orchestrates Helminth-Induced Type 2 Inflammation [PDF]
Trends in Immunology, 2019 Infection with helminth parasites poses a significant challenge to the mammalian immune system. The type 2 immune response to helminth infection is critical in limiting worm-induced tissue damage and expelling parasites. Conversely, aberrant type 2 inflammation can cause debilitating allergic disease.
Lauren M, Webb, Elia D, Tait Wojno
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Epigenetics and immunometabolism in diabetes and aging [PDF]
, 2018 Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation.
Cosentino, Francesco, Guzik, Tomasz J.
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Inflammation, heat shock proteins, and type 2 diabetes [PDF]
Cell Stress and Chaperones, 2009 We propose that type 2 diabetes results from a vicious cycle of metabolically induced inflammation, impaired insulin responsiveness, and subsequent loss of homeostatic signaling. A crucial and previously under-recognized event contributing to this loss of homeostasis is a reduction in heat shock proteins (HSPs, or stress proteins).
Philip L, Hooper, Paul L, Hooper
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Low-dose intestinal Trichuris muris infection alters the lung immune microenvironment and can suppress allergic airway inflammation [PDF]
, 2016 Immunological cross talk between mucosal tissues such as the intestine and the lung is poorly defined during homeostasis and disease. Here, we show that a low-dose infection with the intestinally restricted helminth parasite Trichuris muris results in ...
Antignano, Frann +5 more
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Biological targeted therapy for type 2 inflammation bronchial asthma [PDF]
Xin yixueBronchial asthma is a chronic inflammatory disease of the airway involving multiple inflammatory cells and cytokines. Severe asthma is characterized by recurrent attacks and persistent symptoms such as coughing， chest tightness， shortness of breath， and ...
ZHANG Mingqiang, MU Xiangdong
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Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms [PDF]
, 2018 Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes.
Guzik, Tomasz J. +2 more
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Role of type 2 immunity in intestinal inflammation [PDF]
Current Opinion in Gastroenterology, 2015 Type 2 (Th2) immune responses play important roles in intestinal immunity by contributing to the maintenance of mucosal homeostasis, not only conferring protection against helminthic infection but also participating in pro-inflammatory pathways in chronic intestinal inflammatory disorders, including inflammatory bowel disease.
Bamias, G., Cominelli, F.
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Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population [PDF]
, 2005 Aims Resistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease.
Al-Attas, Omar S. +6 more
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Type 2 Inflammation and Its Role in Dermatologic Diseases. [PDF]
Int J DermatolABSTRACTAtopic dermatitis, prurigo nodularis, and chronic spontaneous urticaria are immune‐mediated, inflammatory skin conditions characterized by intense itch and disease‐specific skin lesions. Despite their different clinical presentations, the three diseases are unified by an aberrant type 2 immune response involving type 2 cytokines, immune cells ...
Chovatiya R +5 more
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