Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes [PDF]
, 2015 Endothelial dysfunction (ED) plays a role in diabetic cardiovascular complications. Hyperglycemia increases cytockines involved in vascular inflammation.
Bertolini, Camilla +10 more
core +1 more source
Inflammation and the etiology of type 2 diabetes [PDF]
Diabetes/Metabolism Research and Reviews, 2005 AbstractType 2 diabetes is increasingly common worldwide and is beginning to strike younger age groups. Almost 90% of all patients with diabetes show insulin resistance, which also precedes the first symptoms of diabetes. The mechanisms underlying the development of insulin resistance are not well understood.
Ake, Sjöholm, Thomas, Nyström
openaire +2 more sources
Environmental allergens trigger type 2 inflammation through ripoptosome activation
Nature Immunology, 2021 Environmental allergens, including fungi, insects and mites, trigger type 2 immunity; however, the innate sensing mechanisms and initial signaling events remain unclear. Herein, we demonstrate that allergens trigger RIPK1-caspase 8 ripoptosome activation in epithelial cells.
Michael Brusilovsky +9 more
openaire +2 more sources
Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. [PDF]
, 2014 The current dogma is that obesity-associated hepatic inflammation is due to increased Kupffer cell (KC) activation. However, recruited hepatic macrophages (RHMs) were recently shown to represent a sizable liver macrophage population in the context of ...
Bandyopadhyay, Gautam +14 more
core +2 more sources
The role of morbid obesity in the promotion of metabolic disruptions and non-alcoholic steatohepatitis by Helicobacter Pylori [PDF]
, 2016 Helicobacter pylory (HP) infection has been associated to an increased rate of type 2 diabetes (T2D) and liver disease through its effect on insulin resistance and systemic inflammation.
Baena-Fustegueras, Juan A +11 more
core +7 more sources
Sex Differences in IL-33-Induced STAT6-Dependent Type 2 Airway Inflammation
Frontiers in Immunology, 2019 Sex differences in asthma prevalence are well-documented but poorly understood. Murine models have contributed to our understanding of mechanisms that could regulate this sex disparity, though the majority of these studies have examined responses present
Hedi Zhao +6 more
doaj +1 more source
Dupilumab improve acquired reactive perforating collagenosis characterized by type 2 inflammation
Frontiers in Immunology, 2023 BackgroundAcquired reactive perforating collagenosis (ARPC) is a clinically challenging disease with an unclear pathogenesis.ObjectiveTo evaluate the efficacy and safety of dupilumab for the treatment of ARPC, and analyze the expression of type 2 ...
Ben Liu +5 more
doaj +1 more source
Increased Hematopoietic Extracellular RNAs and Vesicles in the Lung during Allergic Airway Responses. [PDF]
, 2019 Extracellular RNAs (exRNAs) can be released by numerous cell types in vitro, are often protected within vesicles, and can modify recipient cell function. To determine how the composition and cellular sources of exRNAs and the extracellular vesicles (EVs)
Ansel, K Mark +6 more
core +1 more source
RAGE-mediated inflammation, type 2 diabetes and diabetic vascular complication
Frontiers in Endocrinology, 2013 Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions.
Yasuhiko eYamamoto, Hiroshi eYamamoto
doaj +1 more source
Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets
Frontiers in Physiology, 2022 Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation, whose incidence is rising.
Francesca Racca +19 more
doaj +1 more source