Exopolysaccharide protects Vibrio cholerae from exogenous attacks by the type 6 secretion system [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance This work demonstrates that exopolysaccharide (EPS) produced by Vibrio cholerae can protect against exogenous type 6 secretion system (T6SS) attacks from different bacterial species.
Toska, J, Ho, BT, Mekalanos, JJ
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Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance This work demonstrates that it is possible to alter the prey target range of the antibacterial activity of the type 6 secretion system (T6SS). Being able to change the T6SS target specificity is the first step toward using the T6SS as an antipathogen or commensal therapeutic, prophylactic, or probiotic.
Ho, Brian +3 more
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A Pseudomonas fluorescens type 6 secretion system is related to mucoidy, motility and bacterial competition [PDF]
BMC Microbiology, 2015 Pseudomonas fluorescens strain MFE01 secretes in abundance two Hcp proteins (haemolysin co-regulated proteins) Hcp1 and Hcp2, characteristic of a functional type 6 secretion system. Phenotypic studies have shown that MFE01 has antibacterial activity against a wide range of competitor bacteria, including rhizobacteria and clinically relevant bacteria ...
Decoin, Victorien +7 more
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Prevalence of Acinetobacter baumannii strains expressing the Type 6 secretion system in patients with bacteremia [PDF]
Virulence, 2017 Acinetobacter baumannii (Ab) is an important nosocomial pathogen, of major concern worldwide due to its multi-drug resistance and the recent appearance of hyper-virulent strains in the clinical set...
Repizo GD.
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pH Alkalinization by Chloroquine Suppresses Pathogenic Burkholderia Type 6 Secretion System 1 and Multinucleated Giant Cells [PDF]
Infection and Immunity, 2017 ABSTRACT Burkholderia mallei and B. pseudomallei cause glanders and melioidosis, respectively, in humans and animals. A hallmark of pathogenesis is the formation of granulomas containing multinucleated giant cells (MNGCs) and cell death.
Jennifer, Chua +6 more
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The type 6 secretion system immunity protein RhsFI has been repurposed for small RNA regulation in pathogenic Escherichia coli. [PDF]
Nucleic acids researchRNA-binding proteins (RBPs) play key roles in regulating virulence gene expression in pathogenic enterohaemorrhagic Escherichia coli (EHEC). To capture the RNA-binding proteome in EHEC, total RNA-associated protein purification (TRAPP) was employed and identified 443 RNA-associated proteins.
Zammit, Thomas +15 more
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The type VI secretion system encoded in SPI-6 plays a role in gastrointestinal colonization and systemic spread of Salmonella enterica serovar Typhimurium in the chicken. [PDF]
PLoS ONE, 2013 The role of the Salmonella Pathogenicity Islands (SPIs) in pathogenesis of Salmonella enterica Typhimurium infection in the chicken is poorly studied, while many studies have been completed in murine models.
David Pezoa +5 more
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Проблемы особо опасных инфекцийThe aim of the work was to study the structure of the genes of type 6 secretion system in non-toxigenic strains of Vibrio cholerae O1 serogroup, biovar El Tor and to identify their competitive features. Materials and methods.
A. Yu. Kuratashvili +6 more
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Secretin interactions in the type II secretion system [PDF]
, 2012 PhDThe type II secretion system (T2SS) is the major terminal branch of the general secretory pathway. It is composed of 12-15 proteins, most in multiple copies, and spans the inner and outer membranes of Gram-negative bacteria.
Gu, Shuang
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Distribution, Function and Regulation of Type 6 Secretion Systems of Xanthomonadales [PDF]
Frontiers in Microbiology, 2019 Members of the Xanthomonadales order include several plant pathogens of significant economic and agricultural impact, such as Xanthomonas spp. Type 6 secretion systems (T6SSs) are contractile nanomachines used by many bacterial species to inject protein effectors into target prokaryotic and eukaryotic cells and provide a competitive advantage for ...
Ethel Bayer-Santos +3 more
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