Results 41 to 50 of about 533,494 (308)

Propofol Anesthesia Is Reduced in Phospholipase C–Related Inactive Protein Type-1 Knockout Mice [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2017
The GABA type A receptor (GABAA-R) is a major target of intravenous anesthetics. Phospholipase C-related inactive protein type-1 (PRIP-1) is important in GABAA-R phosphorylation and membrane trafficking. In this study, we investigated the role of PRIP-1 in general anesthetic action.
Keisuke Migita, Junko Yamada, Kazuyoshi Hirota, Tetsuya Kushikata, Yoshikazu Nikaido, Shinya Ueno, Shuji Shimoyama, Masato Hirata, Masato Hirata, Tomonori Furukawa, Kohei Koga, Takashi Kanematsu   +11 more
openaire   +3 more sources

An Emergent Role for Mitochondrial Bioenergetics in the Action of Snake Venom Toxins on Cancer Cells

Frontiers in Oncology, 2022
Beyond the role of mitochondria in apoptosis initiation/execution, some mitochondrial adaptations support the metastasis and chemoresistance of cancer cells. This highlights mitochondria as a promising target for new anticancer strategies.
Félix A. Urra, Félix A. Urra, Félix A. Urra, Dan E. Vivas-Ruiz, Dan E. Vivas-Ruiz, Eladio Flores Sanchez, Eladio Flores Sanchez, Ramiro Araya-Maturana, Ramiro Araya-Maturana, Ramiro Araya-Maturana   +9 more
doaj   +1 more source

Gender differences in the relationships between dietary phytosterols intake and prevalence of obesity in Chinese population

Food Science &Nutrition, Volume 11, Issue 1, Page 569-577, January 2023., 2023
The present study suggests that the intake of total phytosterols (PSs), stigmasterol, ß‐sitosterol, ß‐sitostanol and campestanol were inversely associated with the prevalence of obesity. In addition, lower obesity risk for total PSs and PSs subgroups differed for the gender. These results deserve to be further verified in cohort studies.
Panpan Guo, Rennan Feng, Zixiang Li, Ting Han   +3 more
wiley   +1 more source

The Arabidopsis DREB2 genetic pathway is constitutively repressed by basal phosphoinositide-dependent phospholipase C coupled to diacylglycerol kinase in Arabidopsis thaliana

Frontiers in Plant Science, 2013
Phosphoinositide-dependent phospholipases C (PI-PLCs) are activated in response to various stimuli. They utilize substrates provided by type III-Phosphatidylinositol-4 kinases (PI4KIII) to produce inositol triphosphate and diacylglycerol (DAG) that is ...
Nabila eDjafi, Chantal eVergnolle, Catherine eCantrel, Wojciech eWietrzyński, Elise eDelage, Françoise eCochet, Juliette ePuyaubert, Ludivine eSoubigou-Taconnat, Delphine eGey, Sylvie eCollin, Sandrine eBalzergue, Alain eZachowski, Eric eRuelland   +12 more
doaj   +1 more source

The genetics of venom ontogeny in the eastern diamondback rattlesnake (Crotalus adamanteus) [PDF]

PeerJ, 2017
The same selective forces that give rise to rapid inter- and intraspecific divergence in snake venoms can also favor differences in venoms across life-history stages.
Darin R. Rokyta, Mark J. Margres, Micaiah J. Ward, Elda E. Sanchez   +3 more
doaj   +2 more sources

About Opposition and Duality in Paraconsistent Type Theory [PDF]

EPTCS 357, 2022, pp. 25-37, 2022
A paraconsistent type theory (an extension of a fragment of intuitionistic type theory by adding opposite types) is here extended by adding co-function types. It is shown that, in the extended paraconsistent type system, the opposite type constructor can be viewed as an involution operation that transforms each type into its dual type.
arxiv   +1 more source

Proteomics and immunocharacterization of Asian mountain pit viper (Ovophis monticola) venom.

PLoS ONE, 2021
The venomic profile of Asian mountain pit viper Ovophis monticola is clarified in the present study. Using mass spectrometry-based proteomics, 247 different proteins were identified in crude venom of O. monticola found in Thailand.
Siravit Sitprija, Lawan Chanhome, Onrapak Reamtong, Tipparat Thiangtrongjit, Taksa Vasaruchapong, Orawan Khow, Jureeporn Noiphrom, Panithi Laoungbua, Arissara Tubtimyoy, Narongsak Chaiyabutr, Supeecha Kumkate   +10 more
doaj   +1 more source

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Endogenous phospholipase A2 inhibitors in snakes: a brief overview

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation.
Patrícia Cota Campos, Lutiana Amaral de Melo, Gabriel Latorre Fortes Dias, Consuelo Latorre Fortes-Dias   +3 more
doaj   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source