Results 41 to 50 of about 1,747,398 (243)

Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy

BioMed Research International, 2014
For more than half a century, cytotoxic agents have been investigated as a possible treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues and cell cultures, both normal and tumoral.
L. A. Calderon, J. C. Sobrinho, K. D. Zaqueo, Andréa A de Moura, Amy N Grabner, M. V. Mazzi, S. Marcussi, A. Nomizo, C. F. C. Fernandes, J. Zuliani, B. M. A. Carvalho, S. L. Da Silva, R. Stabeli, A. Soares   +13 more
semanticscholar   +1 more source

Identification of caspase 3 motifs and critical aspartate residues in human Phospholipase D1b and Phopsholipase D2a [PDF]

, 2008
Stimulation of mammalian cells frequently initiates phospholipase D-catalysed hydrolysis of phosphatidylcholine in the plasma membrane to yield phosphatidic acid (PA) a novel lipid messenger.
Ahn, Avila-Flores, Brown, Cazzolli, Chen, Cross, Degterev, Du, Earnshaw, Farquhar, Fisher, Graham Ladds, Guimaraes, Hodgkin, Hui, Iwasaki-Bessho, Kasai, Kusner, Lim, Matthew N. Hodgkin, McDermott, Michelle H. Wright, Michelle J. Farquhar, Mina-olga Aletrari, Nakashima, Nozawa, Oh, O’Luanaigh, Palicz, Park, Ponting, Powner, Powner, Rozengurt, Samejima, Shi, Timmer, Wissing, Xie, Yamada, Zeniou-Meyer, Zhao, Zheng, Zhong   +43 more
core   +1 more source

Propofol Anesthesia Is Reduced in Phospholipase C–Related Inactive Protein Type-1 Knockout Mice [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2017
The GABA type A receptor (GABAA-R) is a major target of intravenous anesthetics. Phospholipase C-related inactive protein type-1 (PRIP-1) is important in GABAA-R phosphorylation and membrane trafficking. In this study, we investigated the role of PRIP-1 in general anesthetic action.
Keisuke Migita, Junko Yamada, Kazuyoshi Hirota, Tetsuya Kushikata, Yoshikazu Nikaido, Shinya Ueno, Shuji Shimoyama, Masato Hirata, Masato Hirata, Tomonori Furukawa, Kohei Koga, Takashi Kanematsu   +11 more
openaire   +3 more sources

An Emergent Role for Mitochondrial Bioenergetics in the Action of Snake Venom Toxins on Cancer Cells

Frontiers in Oncology, 2022
Beyond the role of mitochondria in apoptosis initiation/execution, some mitochondrial adaptations support the metastasis and chemoresistance of cancer cells. This highlights mitochondria as a promising target for new anticancer strategies.
Félix A. Urra, Félix A. Urra, Félix A. Urra, Dan E. Vivas-Ruiz, Dan E. Vivas-Ruiz, Eladio Flores Sanchez, Eladio Flores Sanchez, Ramiro Araya-Maturana, Ramiro Araya-Maturana, Ramiro Araya-Maturana   +9 more
doaj   +1 more source

Autologous Extracellular Cytochrome c Is an Endogenous Ligand for Leucine-rich α2-Glycoprotein and β-Type Phospholipase A2 Inhibitor [PDF]

Journal of Biological Chemistry, 2010
Beta-type phospholipase A(2) inhibitory protein (PLIbeta) from the serum of the venomous snake Gloydius brevicaudus neutralizes basic phospholipase A(2) (PLA(2)) from its own venom, and it has 33% sequence homology with human leucine-rich alpha(2)-glycoprotein (LRG), which has been recently reported to bind cytochrome c (Cyt c) (Cummings, C., Walder, J.
Ryoichi Shirai 白井 僚一, Rikiya Gotou 後藤 力哉, Fumiyasu Hirano 平野 文康, Kiyoshi Ikeda 池田 潔, S Inoué   +4 more
openalex   +4 more sources

A cAMP-binding ectoprotein in the yeast Saccharomyces cerevisiae [PDF]

, 1991
tides 10, 593 ...
Achstetter T., Baroni M. D., Behrens M. M., Biilow R., Bregman D. B., Brunton L. L., Cannon J. F., Caras I. W., Caras I. W., Carr S. A., Clegg C., Conzelmann A., Conzelmann A., Corbin J. D., Cross G. A. M., Dallner G., Davitz M. A., Davitz M. A., DeCamilli P., Doering T. L., Edelman A. M., Ferguson M. A. J., Ferguson M. A. J., Ferguson R., Fersht A., Flockart D. A., Gruber W., Hixson C. S., Ishihara M., Jaynes P. K., Johnson K. E., Kamps M. P., Kiibler D., Korc-Grodzicki B., Kunisawa R., Lang B., Lohmann S. M., Lohmann S. M., Low M. G., Low M. G., Matsumoto K., Matsumoto K., Matsumoto K., Matsumoto K., Matsumoto K., Merino A., Mitts M. R., Mostov K. E., Muller G., Muller G., Muller G., Muller G„, Nairn A. C., Nigam S. K., Nigg E. A., Nigg E. A., Olson S., Pall G., Rhee T., Rodel G., Sakar D., Salomon Y., Smith M. E., Srere P. A., Stieger A., Takami N., Thorner J., Toda T., Trams E. G., Uno I., Vai M., Wen T. C., Wingender-Drissen R.   +72 more
core   +3 more sources

Tissue Type Expression of Phospholipase C β3 in Olive Flounder (Paralichthys olivaceus) Following Various Stimulation [PDF]

Journal of Fisheries and Marine Sciences Education, 2016
Soo-Ji Woo, Hyung Ho Lee, Joon-Ki Chung
openalex   +3 more sources

The genetics of venom ontogeny in the eastern diamondback rattlesnake (Crotalus adamanteus) [PDF]

PeerJ, 2017
The same selective forces that give rise to rapid inter- and intraspecific divergence in snake venoms can also favor differences in venoms across life-history stages.
Darin R. Rokyta, Mark J. Margres, Micaiah J. Ward, Elda E. Sanchez   +3 more
doaj   +2 more sources

Candida albicans pathogenicity mechanisms [PDF]

, 2013
Peer reviewedPublisher ...
Alonso-Monge R, Braun BR, Csank C, De Bernardis F, Diez-Orejas R, Fonzi WA, Hube B, Hwang CS, Mühlschlegel FA, Sorger PK, Wysong DR   +10 more
core   +1 more source

Proteomics and immunocharacterization of Asian mountain pit viper (Ovophis monticola) venom.

PLoS ONE, 2021
The venomic profile of Asian mountain pit viper Ovophis monticola is clarified in the present study. Using mass spectrometry-based proteomics, 247 different proteins were identified in crude venom of O. monticola found in Thailand.
Siravit Sitprija, Lawan Chanhome, Onrapak Reamtong, Tipparat Thiangtrongjit, Taksa Vasaruchapong, Orawan Khow, Jureeporn Noiphrom, Panithi Laoungbua, Arissara Tubtimyoy, Narongsak Chaiyabutr, Supeecha Kumkate   +10 more
doaj   +1 more source