Results 31 to 40 of about 707 (287)

Ontogeny of purinergic receptor-regulated Ca2+ signaling in mouse cortical collecting duct epithelium [PDF]

, 2002
Changes in ATP-induced increase in {[}Ca2+], during collecting duct ontogeny were studied in primary monolayer cultures of mouse ureteric bud (UB) and cortical collecting duct (CCD) cells by Fura-PE3 fluorescence ratio imaging.
Tschop, J., Borscheid, R., Huber, S. M., Braun, G. S., Horster, M. F.   +4 more
core   +1 more source

A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis[S]

Journal of Lipid Research, 2009
Human endothelial lipase (EL) is a member of a family of lipases and phospholipases that are involved in the metabolism of plasma lipoproteins. EL displays a preference to hydrolyze lipids in HDL.
Robert J. Brown, Andrew C. Edmondson, Nathalie Griffon, Theophelus B. Hill, Ilia V. Fuki, Karen O. Badellino, Mingyao Li, Megan L. Wolfe, Muredach P. Reilly, Daniel J. Rader   +9 more
doaj   +1 more source

Yeast Pgc1p (YPL206c) Controls the Amount of Phosphatidylglycerol via a Phospholipase C-type Degradation Mechanism [PDF]

Journal of Biological Chemistry, 2008
The product of the open reading frame YPL206c, Pgc1p, of the yeast Saccharomyces cerevisiae displays homology to bacterial and mammalian glycerophosphodiester phosphodiesterases. Deletion of PGC1 causes an accumulation of the anionic phospholipid, phosphatidylglycerol (PG), especially under conditions of inositol limitation.
Mária, Simocková, Roman, Holic, Dana, Tahotná, Jana, Patton-Vogt, Peter, Griac   +4 more
openaire   +2 more sources

An Emergent Role for Mitochondrial Bioenergetics in the Action of Snake Venom Toxins on Cancer Cells

Frontiers in Oncology, 2022
Beyond the role of mitochondria in apoptosis initiation/execution, some mitochondrial adaptations support the metastasis and chemoresistance of cancer cells. This highlights mitochondria as a promising target for new anticancer strategies.
Félix A. Urra, Félix A. Urra, Félix A. Urra, Dan E. Vivas-Ruiz, Dan E. Vivas-Ruiz, Eladio Flores Sanchez, Eladio Flores Sanchez, Ramiro Araya-Maturana, Ramiro Araya-Maturana, Ramiro Araya-Maturana   +9 more
doaj   +1 more source

The Arabidopsis DREB2 genetic pathway is constitutively repressed by basal phosphoinositide-dependent phospholipase C coupled to diacylglycerol kinase in Arabidopsis thaliana

Frontiers in Plant Science, 2013
Phosphoinositide-dependent phospholipases C (PI-PLCs) are activated in response to various stimuli. They utilize substrates provided by type III-Phosphatidylinositol-4 kinases (PI4KIII) to produce inositol triphosphate and diacylglycerol (DAG) that is ...
Nabila eDjafi, Chantal eVergnolle, Catherine eCantrel, Wojciech eWietrzyński, Elise eDelage, Françoise eCochet, Juliette ePuyaubert, Ludivine eSoubigou-Taconnat, Delphine eGey, Sylvie eCollin, Sandrine eBalzergue, Alain eZachowski, Eric eRuelland   +12 more
doaj   +1 more source

The genetics of venom ontogeny in the eastern diamondback rattlesnake (Crotalus adamanteus) [PDF]

PeerJ, 2017
The same selective forces that give rise to rapid inter- and intraspecific divergence in snake venoms can also favor differences in venoms across life-history stages.
Darin R. Rokyta, Mark J. Margres, Micaiah J. Ward, Elda E. Sanchez   +3 more
doaj   +2 more sources

Biochemistry and toxicology of proteins and peptides purified from the venom of Vipera berus berus

Toxicon: X, 2022
The isolation and characterization of individual snake venom components is important for a deeper understanding of the pathophysiology of envenomation and for improving the therapeutic procedures of patients. It also opens possibilities for the discovery
Jüri Siigur, PhD, Ene Siigur, PhD
doaj   +1 more source

Propofol Anesthesia Is Reduced in Phospholipase C–Related Inactive Protein Type-1 Knockout Mice [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2017
The GABA type A receptor (GABAA-R) is a major target of intravenous anesthetics. Phospholipase C-related inactive protein type-1 (PRIP-1) is important in GABAA-R phosphorylation and membrane trafficking. In this study, we investigated the role of PRIP-1 in general anesthetic action.
Yoshikazu, Nikaido, Tomonori, Furukawa, Shuji, Shimoyama, Junko, Yamada, Keisuke, Migita, Kohei, Koga, Tetsuya, Kushikata, Kazuyoshi, Hirota, Takashi, Kanematsu, Masato, Hirata, Shinya, Ueno   +10 more
openaire   +2 more sources

Endogenous phospholipase A2 inhibitors in snakes: a brief overview

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation.
Patrícia Cota Campos, Lutiana Amaral de Melo, Gabriel Latorre Fortes Dias, Consuelo Latorre Fortes-Dias   +3 more
doaj   +1 more source

Proteomics and immunocharacterization of Asian mountain pit viper (Ovophis monticola) venom.

PLoS ONE, 2021
The venomic profile of Asian mountain pit viper Ovophis monticola is clarified in the present study. Using mass spectrometry-based proteomics, 247 different proteins were identified in crude venom of O. monticola found in Thailand.
Siravit Sitprija, Lawan Chanhome, Onrapak Reamtong, Tipparat Thiangtrongjit, Taksa Vasaruchapong, Orawan Khow, Jureeporn Noiphrom, Panithi Laoungbua, Arissara Tubtimyoy, Narongsak Chaiyabutr, Supeecha Kumkate   +10 more
doaj   +1 more source