Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C [PDF]
Biochemical Journal, 1994 Intracellular Ca2+ responses to extracellular matrix molecules were studied in suspensions of pancreatic acinar cells loaded with Fura-2. Collagen type I, laminin, fibrinogen and fibronectin were unable to raise cytosolic free Ca2+ concentration ([Ca2+]i), whereas collagen type IV, at concentrations from 5 to 50 micrograms/ml, significantly increased ...
László Somogyi +3 more
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Properties of Clostridium Perfringens (Welch II) Type-A -Toxin (Phospholipase c) Purified By Electrofocusing [PDF]
Journal of Medical Microbiology, 1974 SUMMARY Clostridium perfringens type-A α-toxin (phospholipase C) was purified on a preparative scale by a simple, rapid, two-stage procedure involving precipitation of culture-supernatant fluids with ammonium sulphate at 35 to 50% saturation, followed by isoelectric focusing in a pH 4·6 gradient.
C J, Smyth, J P, Arbuthnott
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Isolation and characterization of a γ-type phosphoinositide-specific phospholipase C (PLC-γ2) [PDF]
Biochemical Journal, 1990 A novel bovine spleen phosphoinositide-specific phospholipase C (PLC) has been identified with respect to immunoreactivity with four independent antibodies against each of the PLC isoenzymes, and purified to near homogeneity by sequential column chromatography.
Yoshimi Homma +4 more
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Toxins, 2022 Reports of bite from Protobothrops mucrosquamatus (Pmu) are frequent in Taiwan, and its wide-spread distribution and diverse habitats drove us to investigate its envenoming effects and relevant venom variations.
Liao-Chun Chiang +5 more
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The action of human and rabbit serum phospholipase A2 on Escherichia coli phospholipids.
Journal of Lipid Research, 1980 We have compared the properties of phospholipase A (E.C. 3.1.1.4) activity in whole human and rabbit serum toward the phospholipids of Escherichia coli. Using as substrate E.
L Kaplan-Harris +4 more
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Isolation of cDNAs encoding typical and novel types of phosphoinositide-specific phospholipase C from the moss Physcomitrella patens [PDF]
Journal of Experimental Botany, 2004 Two cDNAs encoding proteins, PpPLC1 and PpPLC2, with catalytic and C2 domains conserved in plant phosphoinositide-specific phospholipase C (PI-PLC) were isolated from Physcomitrella patens. The N domain, which has been identified in Arabidopsis PI-PLCs as an EF hand-like domain, was found in both isoforms, although that in PpPLC2 was a split type.
Koji Mikami +3 more
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Hydrolysis of Phospholipids by phospholipase C in intact cells of wild‐type and envelope mutants of Escherichia coli K12 [PDF]
FEBS Letters, 1981 Zdena Stárková +2 more
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Inhibition of c-fos transcription and phosphorylation of the serum response factor by an inhibitor of phospholipase C-type reactions. [PDF]
Molecular and Cellular Biology, 1990 Phospholipase C activity is necessary for transcriptional c-fos activation by providing diacylglycerol as an activator of protein kinase C. We found that transcriptional activation of c-fos and the phosphorylation of its major transcription factor were inhibited by tricyclodecan-9-yl xanthogenate, which blocks phospholipase C-type reactions ...
G, Schalasta, C, Doppler
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Phenotypes of Pain Behavior in Phospholipase C-Related but Catalytically Inactive Protein Type 1 Knockout Mice [PDF]
Molecular Pain, 2011 Phospholipase C-related inactive protein (PRIP) plays important roles in trafficking to the plasma membrane of GABAA receptor, which is involved in the dominant inhibitory neurotransmission in the spinal cord and plays an important role in nociceptive transmission. However, the role of PRIP in pain sensation remains unknown.
Keisuke Migita +6 more
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Type VI secretion system : secretion by a contractile nanomachine [PDF]
, 2015 The type VI secretion systems (T6SS) are present in about a quarter of all Gram-negative bacteria. Several key components of T6SS are evolutionarily related to components of contractile nanomachines such as phages and R-type pyocins. The T6SS assembly is
Basler, Marek
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