Results 81 to 90 of about 533,494 (308)

$c$-Almost periodic type functions and applications [PDF]

arXiv, 2020
In this paper, we introduce several various classes of $c$-almost periodic type functions and their Stepanov generalizations, where $c\in {\mathbb C}$ and $|c|=1.$ We also consider the corresponding classes of $c$-almost periodic type functions depending on two variables and prove several related composition principles.
arxiv  

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Demonstration of Functionally Different Interactions between Phospholipase C-γ and the Two Types of Platelet-derived Growth Factor Receptors [PDF]

Journal of Biological Chemistry, 1995
Phosphorylated tyrosine residues in receptor tyrosine kinases serve as binding sites for signal transduction molecules. We have identified two autophosphorylation sites, Tyr-988 and Tyr-1018, in the platelet-derived growth factor (PDGF) alpha-receptor carboxyl-terminal tail, which are involved in binding of phospholipase C-gamma (PLC-gamma).
Anders Eriksson, Graham Carpenter, Carl-Henrik Heldin, Ulf Hellman, Lena Claesson-Welsh, Eva Rupp, Lars Rönnstrand, Ulla Engström, Eewa Nånberg   +8 more
openaire   +3 more sources

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

The effects of endocrine‐disrupting chemicals on ovarian‐ and ovulation‐related fertility outcomes

Molecular Reproduction and Development, Volume 89, Issue 12, Page 608-631, December 2022., 2022
Abstract Exposure to endocrine‐disrupting chemicals (EDCs) is unavoidable, which represents a public health concern given the ability of EDCs to target the ovary. However, there is a large gap in the knowledge about the impact of EDCs on ovarian function, including the process of ovulation.
Katie L. Land, Frances G. Miller, Ava C. Fugate, Patrick R. Hannon   +3 more
wiley   +1 more source

A complex extracellular sphingomyelinase of Pseudomonas aeruginosa inhibits angiogenesis by selective cytotoxicity to endothelial cells.

PLoS Pathogens, 2009
The hemolytic phospholipase C (PlcHR) expressed by Pseudomonas aeruginosa is the original member of a Phosphoesterase Superfamily, which includes phosphorylcholine-specific phospholipases C (PC-PLC) produced by frank and opportunistic pathogens.
Michael L Vasil, Martin J Stonehouse, Adriana I Vasil, Sandra J Wadsworth, Howard Goldfine, Robert E Bolcome, Joanne Chan   +6 more
doaj   +1 more source

Contribution of N-Linked Mannosylation Pathway to Candida parapsilosis and Candida tropicalis Biofilm Formation

Infection and Drug Resistance, 2023
Diana M Clavijo-Giraldo,1 Luis A Pérez-García,1,2 Marco J Hernández-Chávez,1 Iván Martínez-Duncker,3 Héctor M Mora-Montes1 1Departamento de Biología, Universidad de Guanajuato, Guanajuato, Gto., México; 2Facultad de Estudios Profesionales Zona Huasteca ...
Clavijo-Giraldo DM, Pérez-García LA, Hernández-Chávez MJ, Martínez-Duncker I, Mora-Montes HM   +4 more
doaj  

Overlapping yet response-specific transcriptome alterations characterize the nature of tobacco-Pseudomonas syringae interactions

Frontiers in Plant Science, 2016
In this study transcriptomic alterations of bacterially induced pattern triggered immunity (PTI) were compared with other types of tobacco-Pseudomonas interactions.
Zoltán eBozsó, Peter G Ott, Evelin eKámán-Tóth, Gábor F Bognár, Miklós ePogány, Ágnes eSzatmári   +5 more
doaj   +1 more source

Development of a Three-Dimensional Multiscale Agent-Based Tumor Model: Simulating Gene-Protein Interaction Profiles, Cell Phenotypes & Multicellular Patterns in Brain Cancer [PDF]

arXiv, 2006
Experimental evidence suggests that epidermal growth factor receptor (EGFR)-mediated activation of the signaling protein phospholipase C gamma plays a critical role in a cancer cell's phenotypic decision to either proliferate or to migrate at a given point in time. Here, we present a novel three-dimensional multiscale agent-based model to simulate this
arxiv  

Multiple and Alternative Sites Make Tau Protein an Adaptable Sticky Surface for the SH3 Domain of Fyn Kinase

Angewandte Chemie International Edition, Accepted Article.
The interaction between the microtubule associated protein Tau and the tyrosine kinase Fyn is believed to play a pivotal role in the early stage of Alzheimer’s disease (AD). Previous studies have identified the SRC Homology 3 (SH3) domain of Fyn as the binding receptor of several proline‐rich motifs in Tau.
Roberto Tira, Giulia Leo, Laura Prandini, Carlo Giorgio Barracchia, Mariapina D’Onofrio, Luca Mollica, Stefano Capaldi, Michael Assfalg, Francesca Munari   +8 more
wiley   +1 more source