Results 101 to 110 of about 707 (287)

Active site mapping of Loxosceles phospholipases D: Biochemical and biological features

, 2016
Brown spider phospholipases D from Loxosceles venoms are among the most widely studied toxins since they induce dermonecrosis, triggering inflammatory responses, increase vascular permeability, cause hemolysis, and renal failure.
Brown, Joan Heller, Caruso, I., Nader, H. B. [UNIFESP], Vuitika, Larissa, Matsubara, F. H., Nader, Helena Bonciani [UNIFESP], Veiga, S. S., Takahashi, H. K. [UNIFESP], Toledo, M. S. [UNIFESP], Caruso, Icaro Putinhon, Senff-Ribeiro, Andrea, Toledo, M. S., Chaim, Olga Meiri, Coronado, Monika Aparecida, Coronado, M. A. [UNESP], Arni, Raghuvir Krishnaswamy, Lima, M. A. [UNIFESP], Coronado, M. A., Takahashi, Helio Kiyoshi [UNIFESP], Nader, H. B., Chaves-Moreira, Daniele, Vuitika, L., Chaim, O. M., Veiga, Silvio Sanches, Toledo, Marcos Sergio [UNIFESP], Caruso, I. [UNESP], Arni, R. K. [UNESP], Murakami, Mario Tyago, Murakami, M. T., Senff-Ribeiro, A., Arni, R. K. C, Lima, Marcelo Andrade [UNIFESP], Takahashi, H. K., Lima, M. A., Chaves-Moreira, D., Matsubara, Fernando Hitomi   +35 more
core   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Coralsnake Venomics: Analyses of Venom Gland Transcriptomes and Proteomes of Six Brazilian Taxa

Toxins, 2017
Venom gland transcriptomes and proteomes of six Micrurus taxa (M. corallinus, M. lemniscatus carvalhoi, M. lemniscatus lemniscatus, M. paraensis, M. spixii spixii, and M.
Steven D. Aird, Nelson Jorge da Silva, Lijun Qiu, Alejandro Villar-Briones, Vera Aparecida Saddi, Mariana Pires de Campos Telles, Miguel L. Grau, Alexander S. Mikheyev   +7 more
doaj   +1 more source

The plant non-specific phospholipase C gene family. Novel competitors in lipid signalling

, 2013
International audienceNon-specific phospholipases C (NPCs) were discovered as a novel type of plant phospholipid-cleaving enzyme homologous to bacterial phosphatidylcholine-specific phospholipases C and responsible for lipid conversion during phosphate ...
Zuzana Krčková, Ruelland, Eric, Martinec, Jan, Martin Potocký, Krčková, Zuzana, Kravets, Volodymyr,, Pejchar, Přemysl, Kravets, Volodymyr, S, Eric Ruelland, Kocourková, Daniela, Volodymyr Kravets, Potocky, Martin, Jan Martinec, Daniela Kocourková, Pokotylo, Igor, Igor Pokotylo, Přemysl Pejchar   +16 more
core   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

Enhancing the Efficacy of Melanoma Treatment: The In Vitro Chemosensitising Impact of Vipera ammodytes Venom on Human Melanoma Cell Lines

Toxins
Research on viper venom has expanded into diverse medical applications, including cancer treatment. This study investigates the potential of Vipera ammodytes venom in oncology, evaluating its cytotoxicity and chemosensitising effects on malignant ...
Giovanni Paolino, Matteo Riccardo Di Nicola, Carla Raggi, Serena Camerini, Marialuisa Casella, Luca Pasquini, Cristiana Zanetti, Vincenzo Russo, Santo Raffaele Mercuri, Luana Lugini, Cristina Federici   +10 more
doaj   +1 more source

In vitro study of micobactérial Phospholipases involved in virulence

, 2010
Les phospholipases et en particulier les phospholipases C sont d'importants facteurs de virulence chez de nombreuses bactéries pathogènes (C. perfringens, B. Cereus et P. aeruginosa). Cependant, peu de choses sont connues sur l'implication de ces enzymes
Bakala n'goma, Jean-claude
core  

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Perioperative Intravenous Dexamethasone Improves Pain and Functional Outcomes After Arthroscopic Rotator Cuff Repair

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate the effect of perioperative dexamethasone on patient‐reported pain, functional outcomes, and minimal clinically important difference (MCID) achievement following arthroscopic rotator cuff repair. Methods Patients who underwent rotator cuff repair between 2013 and 2023 were identified and divided into groups.
Trevor D. Wolterink, Germain Craddock, Joshua P. Castle, Michael A. Gaudiani, Chimdindu Obinero, Alexander S. Jurayj, Christian A. Freitag, Nathan Y. Li, Jared Mahylis, Stephanie J. Muh   +9 more
wiley   +1 more source