Results 111 to 120 of about 18,200 (209)

Draft Genome Sequence of Multidrug-Resistant <i>Acinetobacter baumannii</i> smu isolated from a Bloodstream Infection in Sikkim, India. [PDF]

J Genomics
Sharma R, Das R, Bhutia YR, Pradhan N, Bhattarai A.   +4 more
europepmc   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Molecular Mechanisms Underlying the Pathogenicity of <i>Pseudomonas aeruginosa</i>. [PDF]

Medicina (Kaunas)
Krūmiņa A, Reinis A, Jeske A, Zeltiņa I, Vīksna L.   +4 more
europepmc   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková, Eva Dolejší, Nikolai Chetverikov, Jan Jakubík   +3 more
wiley   +1 more source

DPEP2 suppresses metastasis via NF-κB-mediated epithelial-mesenchymal transition and M2 polarization in p53-loss non-small cell lung cancer. [PDF]

Cancer Cell Int
Liu Y, Zhao Y, Dai Z, Wang J, Sun J, Yang S, Ma R, Chen Q.   +7 more
europepmc   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, EarlyView.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

Conserved Enzymatic Peptides in <i>Bitis arietans</i> Venom Revealed by Comparative Proteomics: Implications for Cross-Reactive Antibody Targeting. [PDF]

Int J Mol Sci
Godoi KS, Portaro FCV, Spencer PJ, Vigerelli H, Silva WDD.   +4 more
europepmc   +1 more source

The lung is more than an organ of gas exchange: immunocompetency, platelets and implications for drug discovery

British Journal of Pharmacology, EarlyView.
Abstract The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action of certain drugs that act on these homeostatic processes, resulting in systemic effects on the ...
Simon C. Pitchford
wiley   +1 more source

Host methylglyoxal activates the <i>Listeria</i> virulence program, allowing bacteria to evade inflammatory phagocytes by cell-to-cell spread. [PDF]

Proc Natl Acad Sci U S A
Anaya-Sanchez A, Ragunathan PT, Hung A, Van Alst AJ, Lobanovska M, Stanley SA, Portnoy DA.   +6 more
europepmc   +1 more source