Results 121 to 130 of about 707 (287)

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Comparative analysis of two complete Corynebacterium ulcerans genomes and detection of candidate virulence factors

, 2011
Trost E, Al-Dilaimi A, Papavasiliou P, et al. Comparative analysis of two complete Corynebacterium ulcerans genomes and detection of candidate virulence factors. BMC Genomics.
Viehöver, Prisca, Sabbadini, Priscila, Trost, Eva ; https://orcid.org/, Santos, Louisy S., Burkovski Andreas, Cíntia S Santos, Viehoever Prisca, Burkovski, Andreas, Soares Siomar C, Dias, Alexandre A., Schneider, Jessica, Ana L Mattos-Guaraldi, Schneider Jessica, Silva, Artur, Almeida, Sintia S., Jessica Schneider, Papavasiliou, Panagiotis, Dorella, Fernanda A., Tauch Andreas, Andreas Burkovski, Santos Cíntia S, Azevedo, Vasco, Eva Trost, Louisy S Santos, Hirata, Raphael Jr, Silva Artur, Sabbadini Priscila, Azevedo Vasco, Tauch, Andreas, Prisca Viehoever, Santos, Cintia S., Schneider Maria P, Miyoshi Anderson, Soares, Siomar C., Siomar C Soares, Vasco Azevedo, Mattos-Guaraldi, Ana L., Fernanda A Dorella, Schneider, Maria P., Maria P Schneider, Miyoshi, Anderson, Al-Dilaimi Arwa, Dorella Fernanda A, Raphael Hirata, Alexandre A Dias, Arwa Al-Dilaimi, Anderson Miyoshi, Al-Dilaimi, Arwa, Hirata Raphael, Almeida Sintia S, Mattos-Guaraldi Ana L, Andreas Tauch, Panagiotis Papavasiliou, Santos Louisy S, Sintia S Almeida, Priscila Sabbadini, Papavasiliou Panagiotis, Artur Silva, Dias Alexandre A, Trost Eva   +59 more
core   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Functional analysis of intracellular phospholipases of Candida albicans

, 2009
Phosphoinositide (PI) sind strukturelle Bestandteile der Zellmembranen und auch an verschiedenen Signalwegen im Zytoplasma und Zellkern beteiligt. Diese Arbeit befasst sich näher mit Phospholipasen der Klasse C, sowie einem Gen mit einer Ähnlichkeit zu ...
Kunze, Donika
core   +1 more source

Examining Phosphatidylethanol (PEth) Formation Rates Within and Between Subjects in Ex Vivo Whole Blood

Drug Testing and Analysis, EarlyView.
PEth formation rate increased with increasing ethanol concentration with variability between participants but was mostly consistent within‐subject. No relationship was observed between phosphatidylcholine concentrations and PEth formation rates. PEth concentrations should be used to monitor an individual's ethanol use over time, rather than compared ...
Haidyn G. Stark, Jesus J. Sanchez, Nathalie Hill‐Kapturczak, John D. Roache, Brett C. Ginsburg   +4 more
wiley   +1 more source

Angiotensin II-mediated activation of L-type calcium channels involves phosphatidylinositol hydrolysis-independent activation of protein kinase C in rat portal vein myocytes.

, 1996
International audienceThe action of angiotensin II (ANG II) was studied in single myocytes from rat portal vein, in which the cytoplasmic Ca++ concentration was estimated by emission from fluorescent dyes and the Ca++ channel current was measured with ...
Morel, J., Mironneau, J., Macrez-Leprêtre, N.   +2 more
core  

Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade.

, 2009
International audienceLike other multicellular organisms, the model nematode C. elegans responds to infection by inducing the expression of defense genes.
Kurz, C Léopold, Couillault, Carole, Cypowyj, Sophie, Pujol, Nathalie, Ziegler, Katja, Ewbank, Jonathan J., Ewbank, Jonathan J, Pophillat, Matthieu, Kurz, C. Léopold   +8 more
core   +1 more source

Recent Progress on Enzyme Immobilization: Materials, Strategies, and Applications

Food Bioengineering, EarlyView.
Enzyme immobilization technology has undergone substantial evolution driven by advances in materials science. This review systematically examines the recent advances in enzyme immobilization since 2024, with a focused analysis of five major categories of enzyme carriers including covalent organic framework, metal‐organic frameworks, polymers, carbon ...
Shuran Wang, Ruoke Li, Yixuan Xie, Hanya Zhang, Xiaoyu Huang, Siwei Chen, Weixin Xu, Yueling Liu   +7 more
wiley   +1 more source

Toxicity Of Phospholipases A2 D49 (6-1 And 6-2) And K49 (bj-vii) From Bothrops Jararacussu Venom

, 2015
Purified phospholipase A2 (PLA2) enzymes from Bothrops jararacussu snake venom were examined to evaluate NIH 3T3 and COS7 fibroblast cytotoxicity, as well as muscle myotoxic and inflammatory activities.
Bonfim V.L., De Carvalho D.D., Ponce-Soto L.A., Kassab B.H., Marangoni S.   +4 more
core   +1 more source

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source