Results 131 to 140 of about 1,669,550 (354)

Regulation of Type I Interferon Gene Expression by Interferon Regulatory Factor-3 [PDF]

, 1998
Susan L. Schafer, Rongtuan Lin, Paul A. Moore, John Hiscott, Paula M. Pitha   +4 more
openalex   +1 more source

TRIM28 facilitates type I interferon activation by targeting TBK1

Frontiers in Immunology
Type I interferons play a fundamental role in innate host defense against viral infections by eliciting the induction of an antiviral gene program that serves to inhibit viral replication.
Fang Hua, Tim Nass, Kislay Parvatiyar
doaj   +1 more source

Enhancement of anti‐Aspergillus T helper type 1 response by interferon‐β‐conditioned dendritic cells [PDF]

, 2010
Valérie Gafa, Maria Elena Remoli, Elena Giacomini, Martina Severa, R. Grillot, Eliana M. Coccia   +5 more
openalex   +1 more source

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

Filamin A inhibits the replication of H5N6 influenza virus via activating the type I interferon signaling pathway [PDF]

, 2018
Xu Shuai, Lu Han, Hualan Chen, Lin‐Fa Wang, Qiyun Zhu, Yan Zeng   +5 more
openalex   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice

Scientific Reports, 2019
Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with fibrosis and emphysema.
Mégane Nascimento, Aurélie Gombault, Norinne Lacerda-Queiroz, Corinne Panek, Florence Savigny, Malak Sbeity, Manon Bourinet, Marc Le Bert, Nicolas Riteau, Bernhard Ryffel, Valérie F. J. Quesniaux, Isabelle Couillin   +11 more
doaj   +1 more source

Hypomethylation of STAT1 and HLA-DRB1 is associated with type-I interferon-dependent HLA-DRB1 expression in lupus CD8+ T cells [PDF]

, 2018
Shaylynn Miller, Patrick Coit, Elizabeth Gensterblum‐Miller, Paul Renauer, Nathan C. Kilian, Mark Schonfeld, Pei‐Suen Tsou, Amr H. Sawalha   +7 more
openalex   +1 more source

Growth Hormone‐Loaded 3D Printed Silk Fibroin‐Cellulose Dressings for Ischemic Wounds

Advanced Healthcare Materials, EarlyView.
3D‐printed wound dressings combining carboxymethyl cellulose, silk fibroin, and growth hormone accelerate healing in diabetic ulcers. These bioactive, customizable dressings enhance angiogenesis, cellular proliferation, and immune modulation. Proteomic analysis reveals activation of regenerative pathways and reduced fibrosis, highlighting their ...
Maria Pita‐Vilar, Diego Caicedo‐Valdés, Susana B. Bravo, Isabel Rodriguez‐Moldes, Salvador D. Aznar‐Cervantes, Angel Concheiro, Carmen Alvarez‐Lorenzo, Luis Diaz‐Gomez   +7 more
wiley   +1 more source

Mutual regulations between Toxoplasma gondii and type I interferon

Frontiers in Immunology
In the decades since the discovery, Type I interferon (IFN-I) has been intensively studied for their antiviral activity. However, increasing evidences suggest that it may also play an important role in the infection of Toxoplasma gondii, a model organism
Lingling Song, Ruoyu Wang, Yuanyuan Cao, Li Yu   +3 more
doaj   +1 more source