Results 141 to 150 of about 521,269 (357)

Signaling by the inhibitory receptor CD200R is rewired by type I interferon

, 2021
Michiel van der Vlist, M Inês Pascoal Ramos, Lucas L. van den Hoogen, Sanne Hiddingh, Laura M. Timmerman, Titus A. P. de Hond, Ellen D. Kaan, Maarten van der Kroef, Robert Jan Lebbink, Florence Peters, William Khoury-Hanold, Ruth Fritsch‐Stork, Timothy R. D. J. Radstake, Linde Meyaard   +13 more
openalex   +2 more sources

229 Comparative immune profiling of four autoimmune skin diseases identifies a mixed type-I and type-II interferon response as a unique inflammatory signature in skin dermatomyositis [PDF]

, 2023
K. Afshari, Y. Wang, N. Haddadi, Carolina S. Lopes, Elizabeth Macdonald, Jane Chuprin, S. Sherman, J. Richmond, Ruth Ann Vleugels, John E. Harris, M. Garber, M. Rashighi   +11 more
openalex   +1 more source

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

MicroRNA-200c-targeted contactin 1 facilitates the replication of influenza A virus by accelerating the degradation of MAVS

PLoS Pathogens, 2022
Influenza A viruses (IAVs) continuously challenge the poultry industry and human health. Elucidation of the host factors that modulate the IAV lifecycle is vital for developing antiviral drugs and vaccines. In this study, we infected A549 cells with IAVs
Shuai Xu, Lu Han, Yanli Wei, Bo Zhang, Qian Wang, Junwen Liu, Minxuan Liu, Zhaoshan Chen, Zhengxiang Wang, Hualan Chen, Qiyun Zhu   +10 more
doaj  

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, EarlyView.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

Editorial: Type I and Type III Interferon Immune Responses in Asthma

Frontiers in Immunology, 2022
Susetta Finotto, Tuomas Jartti, Tuomas Jartti, Tuomas Jartti, Sebastian L. Johnston   +4 more
doaj   +1 more source

Potent Inhibitory Effects of Type I Interferons on Human Adrenocortical Carcinoma Cell Growth [PDF]

, 2006
Peter M. van Koetsveld, Giovanni Vitale, Wouter W. de Herder, Richard A. Feelders, Katy van der Wansem, Marlijn Waaijers, Casper H.J. van Eijck, Ernst‐Jan M. Speel, Ed Croze, Aart‐Jan van der Lely, Steven W. J. Lamberts, Leo J. Hofland   +11 more
openalex   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

NSUN2-mediated m ⁵ C methylation of IRF3 mRNA negatively regulates type I interferon responses [PDF]

, 2021
Hongyun Wang, Lu Zhang, Cong Zeng, Jiangpeng Feng, Dehe Wang, Miao He, Ao Jiang, Yuanyuan Cao, Xiao Guo, Jiejie Liu, Kun Yan, Hao Tang, Ke Xu, Chengpeng Fan, Deyin Guo, Ke Lan, Yu Zhou, Yu Chen   +17 more
openalex   +1 more source