Results 131 to 140 of about 521,269 (357)

Mutual regulations between Toxoplasma gondii and type I interferon

Frontiers in Immunology
In the decades since the discovery, Type I interferon (IFN-I) has been intensively studied for their antiviral activity. However, increasing evidences suggest that it may also play an important role in the infection of Toxoplasma gondii, a model organism
Lingling Song, Ruoyu Wang, Yuanyuan Cao, Li Yu   +3 more
doaj   +1 more source

Predictability of IL-28B-polymorphism on protease-inhibitor-based triple-therapy in chronic HCV-genotype-1 patients: A meta-analysis

, 2014
AIM: To investigate the predictability of interleukin-28B single nucleotide polymorphism rs12979860 with respect to sustained virological response (SVR) in chronically hepatitis C virus (HCV) genotype-1 patients treated with a protease-inhibitor and ...
Amanzada, Ahmad, Cameron, Silke, Mechie, Nicolae-Catalin, Röver, Christian   +3 more
core   +1 more source

Truncation of the NS1 protein converts a low pathogenic avian influenza virus into a strong interferon inducer in duck cells [PDF]

, 2010
The NS1 protein of influenza A viruses is known as a nonessential virulence factor inhibiting type I interferon (IFN) production in mammals and in chicken cells. Whether NS1 inhibits the induction of type I IFNs in duck cells is currently unknown.
Guérin, Jean-Luc, Soubiès, Sébastien, Volmer, Christelle, Volmer, Romain   +3 more
core   +1 more source

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

Advanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He, Lingxiao Zhang, Yue Xiong, Yu Wang, Yuqing Zeng, Dandan Su, Ran Wang, Ying Li, Hongbo Chen, Fang Cheng, Zhi Ping Xu   +10 more
wiley   +1 more source

Kallikrein–Kinin System Suppresses Type I Interferon Responses: A Novel Pathway of Interferon Regulation

Frontiers in Immunology, 2018
The Kallikrein–Kinin System (KKS), comprised of kallikreins (klks), bradykinins (BKs) angiotensin-converting enzyme (ACE), and many other molecules, regulates a number of physiological processes, including inflammation, coagulation, angiogenesis, and ...
Alecia Seliga, Michael Hweemoon Lee, Nicole C. Fernandes, Viviana Zuluaga-Ramirez, Marta Didukh, Yuri Persidsky, Raghava Potula, Stefania Gallucci, Uma Sriram   +8 more
doaj   +1 more source

Distinct Roles of Type I and Type III Interferons during a Native Murine β Coronavirus Lung Infection

, 2021
Lokesh Sharma, Xiaohua Peng, Hua Qing, Brandon K. Hilliard, Jooyoung Kim, Anush Swaminathan, Justin Tian, Kavita Israni-Winger, Cuiling Zhang, Victoria Habet, Lin Wang, Gayatri Gupta, Xuefei Tian, Yina Ma, Hyeon-Jun Shin, Sang-Hun Kim, Min-Jong Kang, Shuta Ishibe, Lawrence H. Young, Sergei Kotenko, Susan Compton, Craig B. Wilen, Andrew Wang, Charles S. Dela Cruz   +23 more
openalex   +2 more sources

1178 Mechanisms of type I interferon-mediated UVB sensitivity in human keratinocytes [PDF]

, 2023
N. Haddadi, K. Afshari, Y. Wang, S. Sherman, M. Garber, R. Vleugels, M. Orzalli, M. Rashighi   +7 more
openalex   +1 more source

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

TRIM28 facilitates type I interferon activation by targeting TBK1

Frontiers in Immunology
Type I interferons play a fundamental role in innate host defense against viral infections by eliciting the induction of an antiviral gene program that serves to inhibit viral replication.
Fang Hua, Tim Nass, Kislay Parvatiyar
doaj   +1 more source

Immune Escape via a Transient Gene Expression Program Enables Productive Replication of a Latent Pathogen

Cell Reports, 2017
How type I and II interferons prevent periodic reemergence of latent pathogens in tissues of diverse cell types remains unknown. Using homogeneous neuron cultures latently infected with herpes simplex virus 1, we show that extrinsic type I or II ...
Jessica A. Linderman, Mariko Kobayashi, Vinayak Rayannavar, John J. Fak, Robert B. Darnell, Moses V. Chao, Angus C. Wilson, Ian Mohr   +7 more
doaj   +1 more source