Results 171 to 180 of about 316,467 (262)

Correction: TRIM21 regulation of IRF-mediated type I interferon signaling in systemic autoimmune diseases. [PDF]

Front Immunol
Panlu K, Wang Y, Zhu X, Lin Z, Fang T, Yao X, Xie Z, Wang X.   +7 more
europepmc   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Age- and Sex-Dependent Variation in the Type I Interferon Signature of Healthy Individuals. [PDF]

Medicina (Kaunas)
Galliano I, Volpe M, Calvi C, Pavan M, Massobrio A, Gambarino S, Albiani R, Linari C, Clemente A, Pau A, Montanari P, Bergallo M.   +11 more
europepmc   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Aging Reshapes γ/δ T-Cell Immunity Through a Type I Interferon-Foxo1 Axis. [PDF]

Aging Cell
Durand A, Porte S, Xing E, Wu C, Le Bon A, Auffray C, Lucas B, Martin B.   +7 more
europepmc   +1 more source

Engineered Au@CeO2 Hybrid Nanoparticles With Microenvironment Dependent Self‐Adjustability for Integration of Tumor‐Specific Photothermal‐Chemodynamic Therapy and Inflammation Prevention

Advanced Science, EarlyView.
An intelligent Au@CeO2 Hybrid Nanoparticles (ACEF) with microenvironment‐dependent self‐adjustability was engineered to not only perform efficient and tumor‐specific photothermal‐chemodynamic therapy for precise tumor elimination, but also serve as a ROS scavenger in healthy tissues around the tumor to avoid the unexpected oxidative damage and ...
Wenyun Mu, Wenjuan Tang, Handan Zhang, Jie Liu, Jiaqi Zhang, Yu Yao, Xiao Fu, Xin Chen, Yanmin Zhang   +8 more
wiley   +1 more source

HSPA6 is induced by RIG-I-like receptors and negatively regulates type-I interferon signaling. [PDF]

Cell Mol Life Sci
Liu Y, Zhao Z, Ji X, Lei Y, Zheng D, Huang Y, An J, Gao C, Wang Z, Si Y, Chen X, Li X, Peng S, Yu H, Liu Z, Zhu Z, Mu X.   +16 more
europepmc   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Human ISG15 deficiency unveils impaired healing of ulcerations via type I interferon-mediated fibrosis. [PDF]

J Hum Immun
Sazeides C, Cuollo L, Sidhu I, Randolph HE, Martin-Fernandez M, Buta S, Stewart OJ, Geltman R, Adalsteinsson JA, Phelps RG, Horowitz A, Stein D, Youssef M, Martinez-Muniz A, Hernandez M, Lionakis MS, Boneparth A, Milner JD, Naik S, Bogunovic D.   +19 more
europepmc   +1 more source