Results 191 to 200 of about 521,269 (357)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Calreticulin and type I interferon: An unsuspected connection

OncoImmunology, 2017
Lorenzo Galluzzi, Guido Kroemer
doaj   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses. [PDF]

J Exp Med
Vila IK, Messaoud-Nacer Y, Taffoni C, Jardine J, Eloiflin RJ, Augereau A, Guha S, Schussler M, Le Hars P, McKellar J, Carvalho T, Postal J, Chemarin M, Re J, Guivel-Benhassine F, Lopez R, Trillet K, Barrat J, Serbier M, El Mansouri I, Luchsinger C, Chrousos GP, Porrot F, Diaz-Griffero F, Schwartz O, Blanchet FP, Majzoub K, Bidère N, Vlachakis D, Laguette N.   +29 more
europepmc   +1 more source

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

, 2016
Melissa E. Munroe, Rufei Lu, Yan D. Zhao, Dustin Fife, Julie M. Robertson, Joel M. Guthridge, Timothy B. Niewold, George C. Tsokos, Michael P. Keith, John B. Harley, Judith A. James   +10 more
openalex   +2 more sources

Influenza A Virus TRIMs the Type I Interferon Response [PDF]

, 2009
Stephan Ludwig, Thorsten Wolff
openalex   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Lectin pathway of complement in SLE: MAP-1 as a marker of haematological manifestations and elevated type I interferon activity. [PDF]

Lupus Sci Med
Lindelöf L, Garred P, Hong MG, Wahl Vælum S, Holten Petersen L, Leonard D, Sayadi A, Oke V, Niewold TB, Diaz-Gallo LM, Saevarsdottir S, Gunnarsson I, Svenungsson E, Eriksson O.   +13 more
europepmc   +1 more source

Identification of a small molecule that primes the type I interferon response to cytosolic DNA [PDF]

, 2017
Samira Khiar, Marianne Lucas‐Hourani, Sébastien Nisole, Nikaïa Smith, Olivier Helynck, Maryline Bourgine, Claude Ruffié, Jean‐Philippe Herbeuval, Hélène Munier‐Lehmann, Frédéric Tangy, Pierre‐Olivier Vidalain   +10 more
openalex   +1 more source