Results 211 to 220 of about 28,369,893 (296)

CD8 T Cell Sensing of Type I Interferon Impacts Anergy. [PDF]

Eur J Immunol
Haefke AS, Gröber H, Sandu I, Skipness V, Pantouloufos N, Gräbnitz F, Tuchel ME, Zangger N, Stark D, Kříž M, Cristinzio C, Pircher H, Spörri R, Quast I, Oxenius A.   +14 more
europepmc   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Elevated CHAF1A Suppresses Type I Interferon Production and Causes Immunotherapy Resistance in Esophageal Squamous Cell Carcinoma. [PDF]

Cancer Immunol Res
Ma Y, Shi M, Ma M, Li S, Cui N, Li Y, Dang T, Yang R, Bai Y, Wang B, Zhang C, Liu C, Zhang Y.   +12 more
europepmc   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

PARP inhibitor YCH1899 activates type I interferon signaling and synergizes with STING agonists in BRCA-proficient tumors. [PDF]

Mol Biomed
Jia L, Cao MH, Sun YT, Bao XB, Zhu WT, Cheng YJ, Wang LM, Yang H, Song SS, Tian CQ, Miao ZH, Yang CH, He JX.   +12 more
europepmc   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Oncogenic KRAS-driven type I interferon signalling primes pancreatic cancer for necroptosis. [PDF]

Nat Commun
Tishina S, Dahlhaus A, Manik M, Mulalic L, Murr J, Kotliar M, Rakhsh-Khorshid H, Kostopoulou M, Hocher F, Stroh J, Beck J, Williams RM, Balta GG, Liu F, Abdallah AT, Bebber CM, Reese M, Lim JKM, Quaas A, Brägelmann J, Pasparakis M, Beleggia F, Balachandran S, Trauzold A, Liccardi G, Astsaturov I, Reichert M, Androulidaki A, von Karstedt S.   +28 more
europepmc   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

IFNIKB: a type I interferon database for antitumuor immunity studies. [PDF]

Database (Oxford)
Ma F, Li K, Yu Y, Zhang L, Zhang L, Li B, Zhang L.   +6 more
europepmc   +1 more source