Results 231 to 240 of about 28,369,893 (296)

Anti-Type I Interferon Autoantibodies in COVID-19 and Systemic Lupus Erythematosus: A Comparative Review. [PDF]

Antibodies (Basel)
Lim XR, Teo RXW, Par RYX, Leung BPL.
europepmc   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Variability in the TLR3 type I interferon pathway is predictive of RNA vaccine responses. [PDF]

Sci Adv
Ng WW, Sugrue J, Rosa Duque JS, Rouilly V, Bondet V, Albert C, Dubois F, Robert M, Leung D, Chung P, Luk THY, Li ABS, Hung RL, Villain E, Briard M, Yip G, Consortium MI, Larocque D, Patin E, Quintana-Murci L, Leung GM, Ni MY, Goncalves P, Schwartz O, Di Santo J, Bruzzone R, Peiris M, Lau YL, Duffy D.   +28 more
europepmc   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Noncanonical bactericidal activity of teleost type I interferon is conferred by a membrane-targeting C-terminal peptide. [PDF]

PLoS Pathog
Zhang H, Wu Y, Zheng X, Wang Z, Zhang C, Cao Z, Ao J, Zhou Y, Sun Y.   +8 more
europepmc   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

NLRX1 contributes to immunotherapeutic resistance of head and neck squamous cell carcinoma by suppressing type I interferon pathway. [PDF]

Front Immunol
Wu Y, Jiang Y, Pan D, Zhang Z, Chen Q, Luo X.   +5 more
europepmc   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source

Type I interferon pathway activation in connective tissue disease associated interstitial lung disease. [PDF]

Front Immunol
Defesche TM, Koudstaal T, Versnel MA, Corneth OBJ, Brkic Z.   +4 more
europepmc   +1 more source