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The Receptor of the Type I Interferon Family
2007All type I IFNs act through a single cell surface receptor composed of the IFNAR1 and IFNAR2 subunits and two associated cytoplasmic tyrosine kinases of the Janus family, Tyk2 and Jak1. A central issue in type I IFN biology is to understand how a multitude of subtypes can generate similar signaling outputs but also govern specific cellular responses ...
Uzé, G. +3 more
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Virologie (Montrouge, France)
Type I interferons (IFNa/b) form a family of related cytokines that include INFa, b, e/s, j, x (human) and limitin (mouse). These cytokines exert a potent antiviral activity, control cell proliferation and modulate the immune response. They are used in the fight against viral infections, tumors, and multiple sclerosis.
S, Delhaye +4 more
openaire +1 more source
Type I interferons (IFNa/b) form a family of related cytokines that include INFa, b, e/s, j, x (human) and limitin (mouse). These cytokines exert a potent antiviral activity, control cell proliferation and modulate the immune response. They are used in the fight against viral infections, tumors, and multiple sclerosis.
S, Delhaye +4 more
openaire +1 more source
Viral recognition and the antiviral interferon response
EMBO Journal, 2023Hans Henrik Gad +2 more
exaly
Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes
Cell, 2016Juan Luis Mendoza +2 more
exaly
Interferon-Stimulated Genes: What Do They All Do?
Annual Review of Virology, 2019John Schoggins
exaly
Type I interferon and type I interferon induced biomarkers in dermatomyositis: A systematic review
Journal of the European Academy of Dermatology and VenereologyRyan S. Q. Geng +6 more
openaire +2 more sources