Results 221 to 230 of about 521,269 (357)

Type I interferon controls vertical transmission and fetoplacental infection of Oropouche virus. [PDF]

iScience
Muraro SP, de Souza GF, Alippe Y, Simeoni CL, Vieira A, Forato J, Lavagnini PM, Polonio CM, de Oliveira LG, Martini MC, Hua X, Elam-Noll M, de Souza WM, Borges LF, Costa ML, Peron JPS, Diamond MS, Proenca-Modena JL.   +17 more
europepmc   +1 more source

Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection [PDF]

, 2015
Ren-Huan Xu, Eric B. Wong, Daniel Rubio, Felicia Roscoe, Xueying Ma, Savita Nair, Sanda Remakus, Reto A. Schwendener, Shinu John, Mark J. Shlomchik, Luis J. Sigal   +10 more
openalex   +1 more source

Table S1 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic Dysfunction

, 2023
In-Young Jung, Robert L. Bartoszek, Andrew J. Rech, Sierra M. Collins, Soon‐Keat Ooi, Erik F. Williams, Caitlin R. Hopkins, Vivek Narayan, Naomi B. Haas, Noelle V. Frey, Elizabeth O. Hexner, Donald L. Siegel, Gabriela Plesa, David L. Porter, Adrian Cantu, J.K. Everett, Sònia Guedan, Shelley L. Berger, Frederic D. Bushman, Friederike Herbst, Joseph A. Fraietta   +20 more
openalex   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Aging Reshapes γ/δ T-Cell Immunity Through a Type I Interferon-Foxo1 Axis. [PDF]

Aging Cell
Durand A, Porte S, Xing E, Wu C, Le Bon A, Auffray C, Lucas B, Martin B.   +7 more
europepmc   +1 more source

Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio‐Immunotherapy

Advanced Science, EarlyView.
A CD44‐targeted MnPt bimetallic nanozyme (HD@MnO2) integrates multienzyme‐like activity with cGAS–STING activation to boost radio‐immunotherapy. Through cascade biocatalysis, it depletes glutathione, relieves hypoxia, and amplifies ROS, enhancing radiotherapy‐induced DNA damage and immunogenic cell death. The nanozyme promotes dendritic cell maturation
Wenyi Zhang, Yangyang Guo, Guoping Xu, Luhaoxiang Liu, Lin Chen, Cai Zhang, Yiming Li, Jianmin Li, Yang Zhao   +8 more
wiley   +1 more source

PO:25:079 | Anifrolumab in refractory dermatomyositis: a case report

Reumatismo
Background. Dermatomyositis is a rare autoimmune disease characterized by multisystem involvement. Treatment can be challenging, particularly in refractory cases unresponsive to conventional therapies, for which standardized management protocols are ...
Società Italiana di Reumatologia
doaj  

Cell-Intrinsic Type I Interferon Signaling as a Pleiotropic Orchestrator of CD4 T Cell Immunity. [PDF]

Biomolecules
Baffoe E, Anand AA, McKinstry KK.
europepmc   +1 more source

DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy

Advanced Science, EarlyView.
Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi, Fei Li, Heng Jiang, Lingling Gu, Mengjie Sun, Kunyu Lu, Pianpian Liu, Ruyue Xie, Wenqiang Ma, Meijuan Zheng, Xianwei Wang, Xuefu Wang, Jingjing Cong   +12 more
wiley   +1 more source

Age- and Sex-Dependent Variation in the Type I Interferon Signature of Healthy Individuals. [PDF]

Medicina (Kaunas)
Galliano I, Volpe M, Calvi C, Pavan M, Massobrio A, Gambarino S, Albiani R, Linari C, Clemente A, Pau A, Montanari P, Bergallo M.   +11 more
europepmc   +1 more source