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Current Opinion in Rheumatology, 2009
Patients with lupus have signs of an ongoing production of type I interferons (IFNs) that are of importance both for the etiopathogenesis and the clinical manifestations. In this review, we summarize the latest information concerning the type I IFN system in lupus.Activated plasmacytoid dendritic cells are responsible for the IFNalpha production in ...
Lars, Rönnblom +2 more
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Patients with lupus have signs of an ongoing production of type I interferons (IFNs) that are of importance both for the etiopathogenesis and the clinical manifestations. In this review, we summarize the latest information concerning the type I IFN system in lupus.Activated plasmacytoid dendritic cells are responsible for the IFNalpha production in ...
Lars, Rönnblom +2 more
openaire +2 more sources
Type I and Type II Interferon Receptors
Journal of Interferon Research, 1984Binding site competition studies of 125I-interferon (IFN)-gamma were performed with homogeneous preparations of IFNs alpha 2, beta, and gamma. It was found that only IFN-gamma could compete for the specific binding site of 125I-IFN-gamma in both WISH and FS11 cells.
P, Orchansky +3 more
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Type I interferon genes and proteins
Biotherapy, 1996The large number of type I interferon genes in mammalian species could be explained by simple redundancy, by different functions for different interferons, or by different spatial or temporal patterns of expression. Different functions would require different receptors for each interferon, while different patterns of expression would require different ...
M O, Díaz, D, Testa
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Type I Interferons in Autoimmune Disease
Annual Review of Pathology: Mechanisms of Disease, 2019Type I interferons, which make up the first cytokine family to be described and are the essential mediators of antivirus host defense, have emerged as central elements in the immunopathology of systemic autoimmune diseases, with systemic lupus erythematosus as the prototype.
Mary K, Crow +2 more
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Type I-interferon signalling in fish
Fish & Shellfish Immunology, 2002Type I interferon (IFN) signalling uses a dual mechanism of action. A Jak-Stat pathway extensively described in mammals involves a cascade of reactions from the interaction of the IFN molecule with its membrane receptor to the stimulation of IFN-induced gene promoters leading in turn to an antiviral state. Regulation of IFN activity is also mediated by
Bertrand, Collet +1 more
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Type I interferons in anticancer immunity
Nature Reviews Immunology, 2015Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this Review, we discuss accumulating evidence indicating that type I IFNs produced by malignant cells or tumour-infiltrating dendritic cells also control the autocrine or paracrine circuits that underlie cancer immunosurveillance.
Zitvogel, Laurence +4 more
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Type I interferons: expression and signalization
Cellular and Molecular Life Sciences CMLS, 1998Type I interferon (IFN-A and IFN-B) genes encode a large family of multifunctional secreted proteins involved in antiviral defence, cell growth regulation and immune activation. These cytokines, as a consequence of their biological activities, have been established as effective therapeutic molecules for malignant and viral diseases.
J, Doly, A, Civas, S, Navarro, G, Uze
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The Receptor of the Type I Interferon Family
2007All type I IFNs act through a single cell surface receptor composed of the IFNAR1 and IFNAR2 subunits and two associated cytoplasmic tyrosine kinases of the Janus family, Tyk2 and Jak1. A central issue in type I IFN biology is to understand how a multitude of subtypes can generate similar signaling outputs but also govern specific cellular responses ...
Uzé, G. +3 more
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Measurement of Type I Interferon Production
Current Protocols in Immunology, 2011AbstractThe Basic Protocol in this unit describes measurement of murine interferon (IFN)α/β by intracellular staining for these cytokines and detection by flow cytometry. Alternate protocols detail an enzyme‐linked immunoabsorbent assay (ELISA) for IFNα and a biological assay to measure IFN.
Rosalind E, Seeds, Joanna L, Miller
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Journal of Interferon & Cytokine Research, 2015
As in bacterial infections and endotoxin shock, type I interferons (IFNs) also have complex and often opposing effects in various models of autoimmune disease. We have shown that type I IFN paradoxically inhibits autoimmune diabetes in the nonobese diabetic mouse (NOD) and biobreeding (BB) rat.
Douglas, Sobel +2 more
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As in bacterial infections and endotoxin shock, type I interferons (IFNs) also have complex and often opposing effects in various models of autoimmune disease. We have shown that type I IFN paradoxically inhibits autoimmune diabetes in the nonobese diabetic mouse (NOD) and biobreeding (BB) rat.
Douglas, Sobel +2 more
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